2013
DOI: 10.1016/j.ophtha.2012.08.019
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The p53 Codon 72 Polymorphism (rs1042522) Is Associated with Proliferative Vitreoretinopathy

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Cited by 41 publications
(38 citation statements)
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“…It is noteworthy, that this study could not replicate the previously described TGF-␤ association (Sanabria Ruiz-Colmenares et al, 2006). Pastor-Idoate et al (2013) found a 'pro' version of the p53 codon 72 polymorphism to be associated with a high risk of PVR after retinal detachment. These findings strongly suggest the influence of gene polymorphism in the development of PVR.…”
Section: Genetic Risk Of Rrdcontrasting
confidence: 95%
“…It is noteworthy, that this study could not replicate the previously described TGF-␤ association (Sanabria Ruiz-Colmenares et al, 2006). Pastor-Idoate et al (2013) found a 'pro' version of the p53 codon 72 polymorphism to be associated with a high risk of PVR after retinal detachment. These findings strongly suggest the influence of gene polymorphism in the development of PVR.…”
Section: Genetic Risk Of Rrdcontrasting
confidence: 95%
“…An association between p53 Arg72Pro polymorphism and PVR has been recently reported by our group [33]. According to our results, carriers of the Pro allele of the p53 gene, which are associated with a decrease in apoptotic function of p53, have higher risk of PVR after RD.…”
Section: Discussionsupporting
confidence: 82%
“…Detailed explanation of the exclusion and inclusion criteria for classification of patients has been provided in a previous publication [33]. In brief, all participants were patients with a primary rhegmatogenous RD who underwent surgery.…”
Section: Methodsmentioning
confidence: 99%
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“…Despite advances in surgical techniques, the percentage of unhealed PVR remains high, causing from 5% to 10% failures in retinal surgical repairs. For the above reasons, in the recent years it has become increasingly important to individuate the inflammatory and genetic mechanisms involved in the pathogenesis of PVR, so as to highlight a possible design to be exploited in clinical trials [1116]. …”
Section: Introductionmentioning
confidence: 99%