The paddy frog genome provides insight into the molecular adaptations and regulation of hibernation in ectotherms

Lv, Yunyun; Chen, Chuan; Yan, Chengzhi; Liao, Wenbo

doi:10.1016/j.isci.2024.108844

Cited by 2 publications

References 70 publications

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Constitutive differences in immune gene expression and energy storage phenotypes co-vary with winter environment in wood frogs

Vaziri,

Reid,

Rittenhouse

et al. 2024

Preprint

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Many terrestrial ectotherms have gone to great evolutionary lengths to adapt to long cold winters; some have even evolved the ability to tolerate the freezing of most of the water in the body. Now, however, high-elevation, and high-latitude winters are experiencing an accelerated period of warming. Specialized winter adaptations that promoted fitness in a seasonally frozen environment may soon be superfluous or even maladaptive. We ask whether winter adaptations include changes in immune functions, and whether changing winter conditions could exert disparate effects on populations of a wide-ranging terrestrial ectotherm, the wood frog (Lithobates sylvaticus). By rearing wood frogs from ancestral winter environments that vary in length and temperature in a common garden, and reciprocally exposing post-metamorphic frogs to unfrozen and frozen artificial winter conditions in the lab, we were able to decompose transcriptomic differences in ventral skin gene expression into those that were environmentally induced (responsive to temperature), genetically determined, and those that varied as an interaction between genotype and environment. We found that frogs from harsh ancestral winter environments constitutively upregulated immune processes, including cellular immunity, inflammatory processes, and adaptive immune processes, as compared to frogs from mild ancestral winter environments. Further, we saw that expression of several genes varied in an interaction between genotype and artificial winter. We suggest that just as winter climates likely served as the selective force resulting in remarkable winter adaptations such as freeze tolerance, they also induced constitutive changes in immune gene expression.

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Constitutive differences in immune gene expression and energy storage phenotypes co-vary with winter environment in wood frogs

Vaziri,

Reid,

Rittenhouse

et al. 2024

Preprint

View full text Add to dashboard Cite

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HMicroDB: A Comprehensive Database of Herpetofaunal Microbiota With a Focus on Host Phylogeny, Physiological Traits, and Environment Factors

Li,

Gao,

Shu

et al. 2024

Molecular Ecology Resources

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Symbiotic microbiota strongly impact host physiology. Amphibians and reptiles occupy a pivotal role in the evolutionary history of Animalia, and they are of significant ecological, economic, and scientific value. Many prior studies have found that symbiotic microbiota in herpetofaunal species are closely associated with host phylogeny, physiological traits, and environmental factors; however, insufficient integrated databases hinder researchers from querying, accessing, and reanalyzing these resources. To rectify this, we built the first herpetofaunal microbiota database (HMicroDB; https://herpdb.com/) that integrates 11,697 microbiological samples from 337 host species (covering 23 body sites and associated with 23 host phenotypic or environmental factors), and we identified 11,084 microbial taxa by consistent annotation. The standardised analysis process, cross‐dataset integration, user‐friendly interface, and interactive visualisation make the HMicroDB a powerful resource for researchers to search, browse, and explore the relationships between symbiotic microbiota, hosts, and environment. This facilitates research in host–microbiota coevolution, biological conservation, and resource utilisation.

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The paddy frog genome provides insight into the molecular adaptations and regulation of hibernation in ectotherms

Cited by 2 publications

References 70 publications

Constitutive differences in immune gene expression and energy storage phenotypes co-vary with winter environment in wood frogs

Constitutive differences in immune gene expression and energy storage phenotypes co-vary with winter environment in wood frogs

HMicroDB: A Comprehensive Database of Herpetofaunal Microbiota With a Focus on Host Phylogeny, Physiological Traits, and Environment Factors

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