The pagetoid variant of urothelial carcinoma in situ

Orozco, Roberto; Zwaag, Roger Vander; Murphy, William M.

doi:10.1016/0046-8177(93)90216-4

Cited by 36 publications

(38 citation statements)

References 9 publications

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“…In denuded areas, CIS may only be present in Von Brunn nests, a useful clue in the diagnosis of residual CIS [40]. Rarely, CIS exhibits pagetoid growth [37,51], characterized by large single cells or small clusters of cells within otherwise normal urothelium in the bladder, ureter, urethra, or within prostatic ducts, but also pagetoid cells can be present within squamous metaplasia of the urinary bladder [36]. This variant of CIS is frequently overlooked and may be responsible for unsuspected recurrent disease after surgery.…”

Section: Urothelial Carcinoma In Situmentioning

confidence: 98%

Preneoplastic non-papillary lesions and conditions of the urinary bladder: an update based on the Ancona International Consultation

et al. 2001

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The result of the meeting is represented by a refined classification of the non-papillary intraepithelial lesions and conditions of the urothelium. This classification includes epithelial abnormalities (reactive urothelial atypia and flat urothelial hyperplasia), presumed preneoplastic lesions and conditions (keratinizing squamous and glandular metaplasia, and malignancy-associated cellular changes), as well as preneoplastic (dysplasia) and neoplastic non-invasive (carcinoma in situ) lesions. Each of these lesions is defined with strict morphological criteria in order to provide more accurate information to urologists in managing patients.

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Section: Urothelial Carcinoma In Situmentioning

confidence: 98%

Preneoplastic non-papillary lesions and conditions of the urinary bladder: an update based on the Ancona International Consultation

et al. 2001

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“…Little is known of the biological behavior or clinical significance of this form of CIS [20]. Pagetoid CIS occurs either in cases of primary or secondary CIS [20].…”

Section: Introductionmentioning

confidence: 98%

The pagetoid variant of bladder urothelial carcinoma in situ

López-Beltrán¹,

Luque²,

Moreno³

et al. 2002

Virchows Arch

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Pagetoid urothelial carcinoma in situ (CIS) is a rare variant of bladder cancer that is characterized by an intraepithelial proliferation of large cells arranged singly or in clusters and randomly distributed. These neoplasms deserve recognition and attention, chiefly because they may be overlooked or misdiagnosed as urothelial dysplasia, then causing unsuspected tumor recurrence after surgery. We report on the clinicopathological features and immunohistochemical findings of 11 (14.86%) cases of pagetoid CIS in a retrospective study of 74 cases of conventional carcinoma in situ. Most patients were male ( n=10). Their ages ranged from 31 years to 78 years. The lesion can be present with primary ( n=2) or secondary ( n=9) CIS. Pagetoid CIS is usually a focal lesion occurring in a clinical and histological setting of conventional CIS, and these patients essentially have the same progression and survival rates as patients without pagetoid changes and are treated in the same way. In cases with extensive urothelial denudation, pagetoid CIS may be focally present in otherwise normal-looking urothelium, thus alerting the pathologist to search for additional CIS elsewhere in the bladder. Given that primary extramammary Paget disease of the external genitalia and of the anal canal may extend to the bladder and, conversely, some bladder cases of pagetoid CIS may extend to the urethra, ureter, and beyond to the external genitalia, the differential diagnoses between these two entities represent an important therapeutic consideration. Our data suggest that a panel of immunostains including CK7+/CK20+/TM+ may assist in differentiating urothelial pagetoid CIS from extramammary Paget disease which is known to be CK7+/CK20-.

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“…Two patients had bladder carcinoma with peripheral Pagetoid spread. A limited amount of Pagetoid spread may be observed at the edges of transitional carcinoma in situ of the bladder, 14 but clinically apparent genital EPD as a manifestation of transitional carcinoma is reported only with synchronously or subsequently diagnosed invasive transitional carcinoma.…”

Section: Discussionmentioning

confidence: 99%