The palliative effect of camel milk on hepatic CYP1A1 gene expression and DNA damage induced by fenpropathrin oral intoxication in male rats

Zeid, Ehsan H. Abu; Sharkawy, Nabela I. El; Moustafa, Gihan G.; Anwer, Abeer M.; Nady, Ahmed G. Al

doi:10.1016/j.ecoenv.2020.111296

Cited by 12 publications

(6 citation statements)

References 91 publications

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“…Previous study has reported increased pesticide-induced MDA content . Furthermore, the increased levels of MDA due to FEN exposure have been verified in rats …”

Section: Results and Discussionmentioning

confidence: 53%

“…As compared to R -FEN, S -FEN induced a higher increase in SOD and CAT activity, especially on days 14 and 21. Studies have found that FEN could induce oxidative damage and upregulate SOD and CAT activity in zebrafish, adult rats, and mice brain . Ye et al reported the increased activities of SOD and CAT after fenvalerate and esfenvalerate exposure.…”

Section: Results and Discussionmentioning

confidence: 99%

“…Studies have found that FEN could induce oxidative damage and upregulate SOD and CAT activity in zebrafish, adult rats, and mice brain. 49 Ye et al 50 reported the increased activities of SOD and CAT after fenvalerate and esfenvalerate exposure. Moreover, S-dinotefuran in earthworms had stronger effects on SOD and CAT activities than R-dinotefuran.…”

Section: Enantioselective Effects On Oxidative Stress and Lipid Perox...mentioning

confidence: 99%

“…52 Furthermore, the increased levels of MDA due to FEN exposure have been verified in rats. 49 3.9. Toxicity Effects of R-FEN and S-FEN on Earthworms Using IBR Evaluation.…”

Section: Enantioselective Effects On Oxidative Stress and Lipid Perox...mentioning

confidence: 99%

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Enantiomer-Specific Study of Fenpropathrin in Soil-Earthworm Microcosms: Enantioselective Bioactivity, Bioaccumulation, and Toxicity

Zhang

Yang

Shi

et al. 2022

J. Agric. Food Chem.

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In this study, the enantiomer-specific bioactivity, bioaccumulation, and toxicity of fenpropathrin (FEN) enantiomers were investigated in soil-earthworm microcosms. The bioactivity order was S-FEN > rac-FEN > R-FEN for Spodoptera litura and Conogethes punctiferalis. Moreover, S-FEN was 12.0 and 32.2 times more toxic than rac-FEN and R-FEN to earthworms, respectively. S-FEN degraded faster than R-FEN with the enrichment of R-FEN in the soil environment. Furthermore, the peak-shaped accumulation curves for FEN enantiomers were observed, and R-FEN was preferentially bioaccumulated by earthworms. As compared to R-FEN, S-FEN induced greater changes in the activities of detoxification enzymes, antioxidant enzymes, and malondialdehyde content, which suggested that earthworms exhibited enantioselective defense responses to S-FEN and R-FEN. Integrated biomarker response results indicated that S-FEN exhibited higher toxic effects on earthworms than R-FEN. Finally, molecular simulation revealed that the greater interaction forces between S-FEN and sodium channel protein could be the primary reason for the enantioselective bioactivity and toxicity of FEN enantiomers. This study comprehensively highlights the enantiomer-specific bioactivity, bioaccumulation, toxicity, and mechanism of FEN in soil-earthworm microcosms at the enantiomer level. Our findings will contribute to a better risk assessment of FEN in the soil ecosystem.

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“…Previous study has reported increased pesticide-induced MDA content . Furthermore, the increased levels of MDA due to FEN exposure have been verified in rats …”

Section: Results and Discussionmentioning

confidence: 53%

Section: Results and Discussionmentioning

confidence: 99%

Section: Enantioselective Effects On Oxidative Stress and Lipid Perox...mentioning

confidence: 99%

“…52 Furthermore, the increased levels of MDA due to FEN exposure have been verified in rats. 49 3.9. Toxicity Effects of R-FEN and S-FEN on Earthworms Using IBR Evaluation.…”

Section: Enantioselective Effects On Oxidative Stress and Lipid Perox...mentioning

confidence: 99%

See 2 more Smart Citations

Enantiomer-Specific Study of Fenpropathrin in Soil-Earthworm Microcosms: Enantioselective Bioactivity, Bioaccumulation, and Toxicity

Zhang

Yang

Shi

et al. 2022

J. Agric. Food Chem.

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“…The nephro‐, hepato‐, and reproductive toxicity have been reported; besides the effects on general biochemical parameters of the blood. Bifenthrin induced toxicity in the liver and kidney of mice, [ 6 ] cypermethrin induced hepatotoxicity that involved ROS mediated crosstalk between Nrf2/Keap1 and NF‐κB/iκB‐α, [ 7 ] reduction in red and white blood cell counts and increased IL‐1b production in the liver of mice exposed to sub lethal dose of λ‐cyhalothrin, [ 8 ] induction of hyperthyroidism by cypermethirn via the PI3K/Akt‐FOXA1 cascade, [ 9 ] perturbations in the biochemical parameters of lung, liver, brain, heart and testis of rats by deltamethrin, [ 10 ] permethrin induced hepatotoxicity modulated by oxidative stress and mitochondrial dysfunction, [ 11 ] genotoxicity of fenpropathrin, [ 12 ] multi organ toxicity of pyrethroid based formulations, [ 13 ] liver fibrosis in quails by activation of TGF‐beta1/Smad pathway by Han et al, [ 14 ] nephrotoxicity of fenpropathrin in rats, [ 15 ] nephrotoxicity of rabbits by Anwar et al, [ 16 ] alterations in the sperm proteome of fenvalerate treated rats, [ 17 ] permethrin induced DNA methylation epimutation markers in sperm of rats, [ 18 ] male reproductive toxicity of deltamethrin, [ 19 ] impairment of Leydig and Sertoli cell function and reproductive toxicity of bifenthrin, [ 20,21 ] and loss of male reproductive function due to cypermethrin [ 22 ] are some of the studies published in the last one and half years.…”

Section: Introductionmentioning

confidence: 99%

Effect of a mixture of pyrethroids at doses similar to human exposure through food in the Indian context

Ravula

Yenugu

2022

J Biochem & Molecular Tox

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Residual amounts of pyrethroids were detected in rice and vegetables of the Indian market. Thus, consumers are exposed to a mixture of pyrethroids on a daily basis through food. Though a large number of studies reported the toxic effects of pyrethroids, there are no reports that used doses equivalent to human consumption. In this study, male Wistar rats were exposed daily to a mixture of pyrethroids for 1-15 months which is equivalent to the amount present in rice and vegetables consumed by an average Indian each day. The oxidant-antioxidant status (lipid peroxidation, nitric oxide; activities of catalase, glutathione peroxidase, glutathione S transferase, and superoxide dismutase) and anatomical changes in the general organs (liver, lung, and kidney) and male reproductive tract tissues (caput, cauda, testis, and prostate) were evaluated. Further, liver and kidney function tests, lipid profile, and complete blood picture were analyzed.Increased oxidative stress, perturbations in the antioxidant enzyme activities, and damage to the anatomical architecture were observed. Disturbances in the liver function and lipid profile were significant. Results of our study demonstrate that exposure to a mixture of pyrethroids at a dose that is equivalent to human consumption can cause systemic and reproductive toxicity, which may ultimately result in the development of lifestyle diseases. This first line of evidence will fuel further studies to determine the impact of food-based pyrethroid exposure on the long-term health of humans and to envisage policies to reduce pesticide content in food products.

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The mechanistic pathway induced by fenpropathrin toxicity: Oxidative stress, signaling pathway, and mitochondrial damage

Soliman,

Tohamy,

Prince

et al. 2024

J Biochem & Molecular Tox

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Fenpropathrin (FNP) is a kind of insecticide and acaricide known as pyrethroid. It is very effective, has a wide range of activities, and works quickly. Internationally, it is commonly considered the most powerful pyrethroid insecticide. Nevertheless, an increasing amount of data indicates a substantial link between Fenpropathrin and adverse effects on nontarget species, including liver toxicity, kidney toxicity, nerve damage, and reproductive toxicity. Oxidative stress plays a vital role in the toxicity of fenpropathrin, in addition to its mechanical mechanism. This study offers a thorough examination of the harmful effects of Fenpropathrin on oxidative and mitochondrial processes, as well as the signaling pathways involved in these effects. The significant impact of oxidative stress emphasizes the toxicity of Fenpropathrin.

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The palliative effect of camel milk on hepatic CYP1A1 gene expression and DNA damage induced by fenpropathrin oral intoxication in male rats

Cited by 12 publications

References 91 publications

Enantiomer-Specific Study of Fenpropathrin in Soil-Earthworm Microcosms: Enantioselective Bioactivity, Bioaccumulation, and Toxicity

Enantiomer-Specific Study of Fenpropathrin in Soil-Earthworm Microcosms: Enantioselective Bioactivity, Bioaccumulation, and Toxicity

Effect of a mixture of pyrethroids at doses similar to human exposure through food in the Indian context

The mechanistic pathway induced by fenpropathrin toxicity: Oxidative stress, signaling pathway, and mitochondrial damage

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