The Palliative Radiotherapy of Classic Kaposi’s Sarcoma of Foot Region: Retrospective Evaluation

Akmansu, Müge

doi:10.4999/uhod.09157

Cited by 6 publications

(15 citation statements)

References 20 publications

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“…The most common side effects were infection, pain, dry desquamation, wet desquamation, both wet and dry desquamation, hyperpigmentation, swelling, and edema. In Akmansu et al study, the ratio of acute complications was 54.8% and it was seen that a complete improvement occurred with convenient support therapy and normal foot movements were provided within 2–3 weeks after completion of RT (Akmansu et al, ). In Singh et al, study, acute and late skin toxicity was also not statistically different between the two arms (Singh et al, ).…”

Section: Discussionmentioning

confidence: 99%

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Radiotherapy in the management of classic Kaposi's sarcoma: A single institution experience from Northeast Turkey

Kandaz

Bahat

Güler

et al. 2018

Dermatologic Therapy

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Kaposi sarcoma is a rare adult neoplasm and there has been no certain consensus on standard treatment, either local or systemic. Radiotherapy is an effective, suitable treatment modality. Between 1996 and 2016, patients who were diagnosed with Kaposi sarcoma and referred to our clinic for radiotherapy were included in this retrospective study. Ninety-two patients were examined in total and it was diagnosed that all the patients had non-HIV associated Kaposi's sarcoma. There were 36 (39%) females and 56 (61%) males and female to male ratio was 2/3. Median age at presentation was 72 (30-93) years. Sixty-eight patients (77%) were treated with 8 Gy (1 fraction), 15 patients (16%) were treated with 20 Gy (2 Gy/fraction), four patients (4%) were treated 25 Gy (2.5 Gy/fraction), and five patients (6%) were treated 30 Gy (3 Gy/fraction). The median follow-up time was 72 (5-192) months. The complete response at 5 years was 91.6% with >20 Gy and 89.6% with 8 Gy. Radiotherapy is an effective, suitable treatment modality of Classic Kaposi sarcoma and usually, radiotherapy is well tolerated with minimal side effects.

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Section: Discussionmentioning

confidence: 99%

“…RT is an effective, suitable treatment modality of KS. The literature is reported to produce more than 90% overall response rates and 50-90% of CR rates (Akmansu, G€ oksel, & Erpolat, 2011;Antman & Chang, 2000;Yıldız, Genç, & Aky€ urek, 2006). There is also no consensus on the optimal dose and fractionation of RT of CKS.…”

Section: Toxicity Evaluationmentioning

confidence: 99%

Radiotherapy in the management of classic Kaposi's sarcoma: A single institution experience from Northeast Turkey

Kandaz

Bahat

Güler

et al. 2018

Dermatologic Therapy

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“…Multidisciplinary treatment methods with different responses are applied to CKS therapy such as intralesional interferon alpha, cryotherapy, hormone therapy, laser removal, systemic chemotherapy, infrared coagulation and radiotherapy depending on the clinical form [7]. Radiotherapy is a useful method to improve the quality of life in patients with CKS and the response to treatment usually carries minimal toxicity [8]. CKS is generally considered sensitive to radiation therapy with good palliative and esthetic results, demonstrated with doses greater than 20 Gy [9].…”

Section: Discussionmentioning

confidence: 99%

Classic Kaposi’s sarcoma - complete response to radiation therapy: a case report

Ramírez¹,

Zavala²,

Moran³

et al. 2016

J Med Case Reports

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BackgroundClassic Kaposi’s sarcoma is a lymphatic endothelial cell neoplasm usually present on the skin of the upper and lower extremities. Although it commonly affects human immunodeficiency virus positive patients, there have been some human immunodeficiency virus negative cases reported. We report an uncommon presentation of stage IV classic Kaposi’s sarcoma in an human immunodeficiency virus negative patient in Latin America with complete clinical response using only radiation therapy treatment.Case presentationA 78-year-old Mexican man with no evidence of human immunodeficiency virus infection presented with a painful widespread dermatosis with maculopapular, nodular, violaceous lesions on his legs and ulcerated lesions on his feet. A biopsy confirmed the lesions as classic Kaposi’s sarcoma. Radiotherapy treatment was delivered, prescribing a total dose of 30 Gy in 15 fractions with a complete clinical response within 15 months of follow-up.ConclusionsThis is an unusual case since it is uncommon to use radiation therapy as the single treatment in stage IV classic Kaposi’s sarcoma; the efficacy of the treatment is shown in the impact in our patient’s recurrence-free survival, local control, and palliation of our patient’s symptoms.

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“…Akmansu ve ark. [17] yaptıkları çalışmada ayak bölgesindeki KKS lezyonlarına uygulanan palyatif RT sonuçla-rını değerlendirdiler ve 17 bölgenin 2'sinde kuru deskuamasyon, 2' sinde ağrı, 5 bölgede yaş ve kuru deskuamasyon ve 8 hastada ise enfeksiyon, yaş deskuamasyon ve ağrı komplikasyonu rapor ettiler. Bizim çalışmamızda da hastaların RT 'ye toleransı gayet iyiydi.…”

Section: Bulgularunclassified

Kaposi sarkomu nedeniyle radyoterapi uygulanan 14 hastanın değerlendirilmesi

et al. 2015

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Objective: In our study, we evaluated the clinical characteristics and outcomes of treatment in patients with Kaposi's sarcoma (KS). Methods:The patients undergoing radiotherapy (RT) because of the KS between the years 2005-2012 in Radiation Oncology Department of Dicle University Hospital were included. All patients underwent RT with different dose-fractionation schemes to increase quality of life and to palliate the symptoms. Patients with lesions in multiple regions underwent RT in the same or different dates. Responses to radiotherapy were recorded as complete or partial response.Results: Fourteen patients received radiotherapy because of f KS were evaluated retrospectively. Twenty two different regions of 14 patients underwent RT . Only one patient (4.5%) was performed RT to glans penis as a third region while performed to the two regions in six patients (27.3%). At irradiations, 6 MV and 10 MV photon energies with 6 MeV, 9 MeV and 12 MeV electron energy were used. Water phantom or bolus material was used to obtain a homogeneous dose distribution in the photon irradiation. RT dose administered to a total of 22 different regional was median 800 cGy (Range: 800-3000 cGy). Median number of RT fractions was 1 (Range: 1-10).When treatment response were evaluated stable disease was present in the 4 (18.1%) regions. Partial response was achieved in eight (36.4%) regions, complete response in 10 (45.5%). RT-related common lymphedema in the feet and legs was observed in the four (57.3%) regions in the acute period. Complication of pain was present in two (28.7%) regions. Conclusion:RT is an appropriate and effective treatment regimen in the palliative treatment of KS lesions. Excellent response rates of skin lesions may be obtained by RT. Lesions and symptoms such as itching may be lost after RT. Side effects such as edema and pain may be relieved by supportive treatment. Bulgular: KS nedeniyle radyoterapi uygulanan 14 hasta retrospektif olarak değerlendirildi. On dört hastanın toplam 22 farklı bölgesine RT uygulandı. Altı hastada (%27,3) iki ayrı bölge ışınlanırken, yalnız bir hastada (%4,5) üçüncü bölge olarak glans penisteki lezyona RT uygulandı. Işınla-malarda 6 MV ve 10 MV foton enerjileri ile 6 MeV, 9 MeV ve 12 MeV elektron enerjileri kullanıldı. Foton ışınlamala-rında homojen doz dağılımı elde etmek için su fantomu veya bolus materyali kullanıldı. Uygulanan RT dozu toplam 22 farklı bölge için medyan 800 cGy (800-3000 cGy) idi. RT fraksiyon sayısı medyan 1'di (1-10). Tedavi yanıt-ları değerlendirildiğinde 4 (%18,1) bölgede stabil hastalık mevcuttu. Sekiz (%36,4) tedavi bölgesinde kısmi cevap sağlanırken, 10 (%45,5) bölgede de tam cevap elde edildi. Dört (%57,3) tedavi bölgesinde RT' ye bağlı ayaklarda ve bacaklarda akut dönemde yaygın lenfödem gözlendi. İki (%28,7) bölgede ise ağrı komplikasyonu mevcuttu.Sonuç: RT, KS lezyonlarının palyatif tedavisinde uygun ve etkili bir tedavi rejimidir. RT ile cilt lezyonlarında mü-kemmel cevap oranları elde edilebilir. RT sonrası lezyonlar ve kaşıntı gibi şikayetle...

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The Palliative Radiotherapy of Classic Kaposi’s Sarcoma of Foot Region: Retrospective Evaluation

Cited by 6 publications

References 20 publications

Radiotherapy in the management of classic Kaposi's sarcoma: A single institution experience from Northeast Turkey

Radiotherapy in the management of classic Kaposi's sarcoma: A single institution experience from Northeast Turkey

Classic Kaposi’s sarcoma - complete response to radiation therapy: a case report

Kaposi sarkomu nedeniyle radyoterapi uygulanan 14 hastanın değerlendirilmesi

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