Abstract. The Amesmessa gold prospect is located along a vertical N-S-trending crustal-scale ductile shear zone; stretching lineations are subhorizontal. This major shear zone is a Late Pan African dextral strike-slip fault of the Pharusian Belt of the Tuareg Shield (Algeria). The Amesmessa shear zone is asymmetric: strong thermal and deformational gradients are present along its western border where biotitic ultramylonites are in contact with a rigid Archean complex (In Ouzzal block), whereas there is a progressive gradation, through mylonite then protomylonite, to the Proterozoic gneiss of the Eastern block which displays co-axial Pan African structures. The Amesmessa shear zone is characterized by the presence of a felsic dike complex emplaced during shearing, and forming the most important parent material for ultramylonites. Basic magmas and carbonatites also intruded within the shear zone. The gold-rich quartz veins are located within the ultramylonitic western part of the shear zone. These N-S-trending laminated quartz veins formed during the late increments of shearing (plastic/brittle transition), by repeated syntectonic hydraulic fracturing atong zones of rheological contrast parallel to foliation. The ore mineral association (pyrite, galena, native gold, sphalerite) crystallized in the deformed quartz matrix along late shear planes. Undeformed E-W trending banded quartz veins are present in the mylonitic eastern part of the shear zone; their gold content is low and no native gold has been observed. A strong hydrothermal alteration resulted in the development (along the walls of the N-S gold-bearing quartz veins) of a 5-m-wide carbonate-sericite-albite-pyrite secondary mineral association which implies an important CO2 supply and moderate temperature conditions. There is no alteration halo around the E-W quartz veins. Ultramylonites, hydrothermally altered rocks and quartz veins display similar REE patterns characterized by strong LREE enrichments. Shear-related fluids could be likely parental fluids for the Amesmessa gold mineralization and the associated hydrothermal alteration. Hydrothermal fluids were drawn into dilation zones and filled opening fractures along the main planar discontinuity of the most deformed rocks. The supply of CO2 may come from a deep-seated source as suggested by the presence of carbonatite dikes in the shear zones and the existence of CO2-H20-rich fluid inclusions in quartz. The location of the gold-bearing quartz veins in the western part of the shear zone can be explained by the presence of strong thermal and rheological gradients.Shear zone-hosted vein-type gold deposits are economically important in Archean shields and occur for example in Canada Colvine et al. 1988), Australia (Groves and Phillips 1987) and Southern Africa (Foster and Wilson 1984;Viljoen 1984). These vein-type gold deposits include mainly native gold associated with pyrite and/or arsenopyrite in a quartz gangue; their wall-rocks, which are generally derived from ultramafic-mafic greenstone-belt material, ...