The Pancreas in Primary Biliary Cirrhosis and Primary Sclerosing Cholanitis

Epstein, Owen; Chapman, Roger W.; Lake‐Bakaar, Gerond; Foo, A Y; Rosalki, S B; Sherlock, Sheila

doi:10.1016/s0016-5085(82)80125-x

Cited by 200 publications

(23 citation statements)

References 16 publications

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“…Metabolism of vitamin D is normal in PBC, but malabsorption of both calcium and vitamin D may occur predominantly in latestage disease. Pancreatic insufficiency and celiac disease, which are associated with PBC [69][70][71], may further aggravate malabsorption.…”

Section: Metabolic Bone Diseasementioning

confidence: 99%

Primary biliary cirrhosis

2009

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Section: Metabolic Bone Diseasementioning

confidence: 99%

Primary biliary cirrhosis

2009

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“…Pancreatic fibrosis has been discussed in close association with idiopathic fibrosclerosis; for example, retroperitoneal fibrosis, mediastinal fibrosis, Riedel's thyroiditis, and Sjögren's syndrome 2,10,11. Pancreatic lesions in PSC have also been noted occasionally 6. In approximately 15% of reported patients with PSC, a morphologically abnormal pancreatic duct was shown,12 and some of these patients had clinical features similar to those of chronic pancreatitis, so‐called sclerosing pancreatitis 1,.…”

Section: Discussionmentioning

confidence: 99%

“…Pancreatic lesions in PSC have also been noted occasionally 6. In approximately 15% of reported patients with PSC, a morphologically abnormal pancreatic duct was shown,12 and some of these patients had clinical features similar to those of chronic pancreatitis, so‐called sclerosing pancreatitis 1,. It is not clear whether sclerosing pancreatitis is pancreatic involvement in PSC or a separate disease.…”

Section: Discussionmentioning

confidence: 99%

“…An idiopathic disease characterized by fibrosclerosis in and around both the bile duct and the pancreatic duct has been reported under the names of “lymphoplasmacytic sclerosing pancreatitis with cholangitis,”1 “pancreatic pseudotumor with idiopathic fibrosclerosis,”2 “inflammatory pseudotumor from sclerosing cholangitis,”3 “primary sclerosing pancreatitis and cholangitis,”4 “sclerosing pancreatocholangitis,”5 and others . However, it remains unclear whether these lesions are due to pancreatic involvement in primary sclerosing cholangitis (PSC) or whether they constitute a variant of autoimmune pancreatitis (AIP) or other diseases, and the optimal therapeutic method has not been established.…”

Section: Introductionmentioning

confidence: 99%

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Ajisaka

Fujita

Kaji

et al. 2002

J Hep Bil Pancr Surg

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A 68-year-old man complaining of jaundice was admitted to our hospital in October 1996. Radiological imaging studies, including dynamic computed tomography, endoscopic retrograde cholangiography, and angiography, were highly suggestive of pancreatic head cancer, and laparotomy was performed on October 25, 1996. On gross examination, the pancreas appeared firm, as in chronic pancreatitis, with a mass lesion in the pancreatic head measuring 35 x 35 x 25 mm. A pylorus-preserving pancreatoduodenectomy was carried out. Histological findings were characterized by uniform fibrosis with diffuse lymphoplasmacytic infiltration and lymph follicles in the thickened wall of the bile duct and in and around the pancreas, with acinar atrophy. The histological diagnosis was lymphoplasmacytic sclerosing pancreatocholangitis. Approximately 5 years postoperatively, the patient was alive and well without adjunctive corticosteroid therapy. This positive result suggests that pancreatoduodenectomy may be effective for lymphoplasmacytic sclerosing pancreatocholangitis that is localized in the pancreatic head.

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“…Epstein et al noted changes of diffuse pancreatitis in three of 13 patients with PSC undergoing ERCP, but did not comment on whether the patients were symptomatic. 26 It is perhaps worthy of special note that the length of follow-up for strictures of the confluence and in extrahepatic ductal system, which were not resected, might be considered too short to exclude cholangiocarcinoma as a final diagnosis, although adequate biopsies were obtained in all cases. The authors have, however, some confidence in the histological diagnoses since new information regarding the staining characteristics present in bile duct cancer, and not present in benign stricture disease, have been identified and applied in a large number of cases at Hammersmith Hospital.…”

Section: Discussionmentioning

confidence: 99%

Surgical Approaches in Primary Sclerosing Cholangitis

Collier

Armitage

Hadjis

et al. 1985

Australian and New Zealand Journal of Surgery

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Primary sclerosing cholangitis is an uncommon condition, generally considered to cany a poor prognosis. Based on the distribution of the biliary strictures, treatment groups can be defined. Those patients with localized hilar or predominantly extrahepatic strictures are most likely to be suitable for biliary-enteric bypass and the use of surgical techniques developed for the management of high bile duct strictures are allowing improvement in the results of surgery in this form of the disease. After 3 months to 3 years follow-up (median 16 months) nine of 12 patients treated by surgical biliary decompression are asymptomatic.

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The Pancreas in Primary Biliary Cirrhosis and Primary Sclerosing Cholanitis

Cited by 200 publications

References 16 publications

Primary biliary cirrhosis

Primary biliary cirrhosis

Untitled

Surgical Approaches in Primary Sclerosing Cholangitis

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