The paradox in pneumococcal serotypes: highly invasive does not mean highly lethal

Pletz, Mathias W.; Welte, Tobias; Klugman, Keith P.

doi:10.1183/09031936.00041210

Cited by 15 publications

(9 citation statements)

References 14 publications

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“…Serotypes 1, 5, and 7F have been described as having high potential for invasiveness (these serotypes are carried for a short time) but are associated with milder disease and lower CFRs ( 7 , 9 , 19 , 34 ). As in those studies, we found that serotypes 1 and 5 caused IPD but were not associated with death.…”

Section: Discussionmentioning

confidence: 99%

“…They concluded that so-called “highly invasive” serotypes (including 4, 1, 14, 18C, and 7F), convey a higher risk for invasive disease than do the “low invasive” serotypes (including 3, 15B/C, and 6B), which are more frequently isolated as colonizers ( 7 ). Furthermore, serotype distribution varies with patient age, both in disease and in nasopharyngeal colonization ( 2 , 8 – 10 ).…”

mentioning

confidence: 99%

“…Furthermore, serotype distribution varies with patient age, both in disease and in nasopharyngeal colonization ( 2 , 8 – 10 ). However, evidence exists that pneumococcal invasiveness does not necessarily mean lethality ( 7 ). Low invasive serotypes usually account for higher case-fatality rates (CFRs).…”

mentioning

confidence: 99%

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Risk Factors for Death from Invasive Pneumococcal Disease, Europe, 2010

Navarro-Torné¹,

Dias²,

Hrubá³

et al. 2015

Emerg. Infect. Dis.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Risk Factors for Death from Invasive Pneumococcal Disease, Europe, 2010

Navarro-Torné¹,

Dias²,

Hrubá³

et al. 2015

Emerg. Infect. Dis.

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“…Although isolation of S. pneumoniae from a normally sterile site is always considered a pathogen, recovery from a respiratory site may represent colonization. Despite these limitations, the role of surveillance that is not limited to isolates causing invasive disease is shown by recent studies reporting high case-fatality rates for noninvasive serotypes ( 15 – 17 ). …”

mentioning

confidence: 99%

Pneumococcal Serotypes before and after Introduction of Conjugate Vaccines, United States, 1999–20111

Richter

Heilmann²,

Dohrn³

et al. 2013

Emerg. Infect. Dis.

195

146

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Serotyping data for pneumococci causing invasive and noninvasive disease in 2008–2009 and 2010–2011 from >43 US centers were compared with data from preconjugate vaccine (1999–2000) and postconjugate vaccine (2004–2005) periods. Prevalence of 7-valent pneumococcal conjugate vaccine serotypes decreased from 64% of invasive and 50% of noninvasive isolates in 1999–2000 to 3.8% and 4.2%, respectively, in 2010–2011. Increases in serotype 19A stopped after introduction of 13-valent pneumococcal vaccine (PCV13) in 2010. Prevalences of other predominant serotypes included in or related to PCV13 (3, 6C, 7F) also remained similar for 2008–2009 and 2010–2011. The only major serotype that increased from 2008–2009 to 2010–2011 was nonvaccine serotype 35B. These data show that introduction of the 7-valent vaccine has dramatically decreased prevalence of its serotypes and that addition of serotypes in PCV13 could provide coverage of 39% of isolates that continue to cause disease.

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“…En trabajos previos se ha mencionado que los pacientes con mayor riesgo de muerte fueron los que presentaron infección por los serotipos más prevalentes en portadores 29 . Algunos serotipos, como el 3, están asociados con alta letalidad, pero hay serotipos con bajo poder invasivo y gran letalidad y morbimortalidad 30 . En la muestra que presentamos en este estudio, a pesar de lo que dice la literatura no se evidenció la relación entre los serotipos más frecuentes (3, 7F, 11A, 14, 19A y 22F) y el fallecimiento.…”

Section: G Modelunclassified