The paradox of natural products as pharmaceuticalsExperimental evidences of a mango stem bark extract

Núñez‐Sellés, Alberto J.; Hernández, René Delgado; Garrido, Gabino; García-Rivera, Dagmar; Guevara-García, Mariela; Pardo-Andreu, Gilberto L.

doi:10.1016/j.phrs.2007.01.004

Cited by 44 publications

(13 citation statements)

References 33 publications

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“…A previous study from Alvarez and collaborators [12] showed that asthma patients benefit from oral therapy with Vimang®, the brand name of an aqueous extract of M. indica stem bark that is traditionally used in the Caribbean region to treat respiratory disorders [1], [34], [35]. Accordingly, there are consistent reports demonstrating the efficacy of Vimang® and mangiferin, its prominent active ingredient, in preventing inflammatory changes in murine models of allergy and asthma [21], [36].…”

Section: Discussionmentioning

confidence: 94%

Mangiferin Prevents Guinea Pig Tracheal Contraction via Activation of the Nitric Oxide-Cyclic GMP Pathway

et al. 2013

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Previous studies have described the antispasmodic effect of mangiferin, a natural glucoside xanthone (2-C-β-Dgluco-pyranosyl-1,3,6,7-tetrahydroxyxanthone) that is present in mango trees and other plants, but its mechanism of action remains unknown. The aim of this study was to examine the potential contribution of the nitric oxide-cyclic GMP pathway to the antispasmodic effect of mangiferin on isolated tracheal rings preparations. The functional effect of mangiferin on allergic and non-allergic contraction of guinea pig tracheal rings was assessed in conventional organ baths. Cultured tracheal rings were exposed to mangiferin or vehicle, and nitric oxide synthase (NOS) 3 and cyclic GMP (cGMP) levels were quantified using western blotting and enzyme immunoassays, respectively. Mangiferin (0.1–10 µM) inhibited tracheal contractions induced by distinct stimuli, such as allergen, histamine, 5-hydroxytryptamine or carbachol, in a concentration-dependent manner. Mangiferin also caused marked relaxation of tracheal rings that were precontracted by carbachol, suggesting that it has both anti-contraction and relaxant properties that are prevented by removing the epithelium. The effect of mangiferin was inhibited by the nitric oxide synthase inhibitor, Nω-nitro-L-arginine methyl ester (L-NAME) (100 µM), and the soluble guanylate cyclase inhibitor, 1H-[1], [2], [4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) (10 µM), but not the adenylate cyclase inhibitor, 9-(tetrahydro-2-furyl)adenine (SQ22536) (100 µM). The antispasmodic effect of mangiferin was also sensitive to K+ channel blockers, such as tetraethylammonium (TEA), glibenclamide and apamin. Furthermore, mangiferin inhibited Ca2+-induced contractions in K+ (60 mM)-depolarised tracheal rings preparations. In addition, mangiferin increased NOS3 protein levels and cGMP intracellular levels in cultured tracheal rings. Finally, mangiferin-induced increase in cGMP levels was abrogated by co-incubation with either ODQ or L-NAME. These data suggest that the antispasmodic effect of mangiferin is mediated by epithelium-nitric oxide- and cGMP-dependent mechanisms.

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Section: Discussionmentioning

confidence: 94%

Mangiferin Prevents Guinea Pig Tracheal Contraction via Activation of the Nitric Oxide-Cyclic GMP Pathway

et al. 2013

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“…The lack of effect of Vimang on most behavioural parameters evaluated in the present study indicates that Vimang does not induce overt neurotoxic or detrimental effects on brain function. In fact, clinical interventions with the extract on AIDS patients or elderly persons did not produce visible evidence of neurological deterioration, even at 2-6 months of daily treatment (Nunez-Selles et al, 2007). Nevertheless, further experiments are required to clarify the mechanisms underlying the impairing effect of Vimang on aversive memory.…”

Section: Resultsmentioning

confidence: 98%

Mangifera indica extract (Vimang) impairs aversive memory without affecting open field behaviour or habituation in rats

Preissler¹,

Martins²,

Pardo-Andreu³

et al. 2008

Phytotherapy Research

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Vimang is an aqueous extract of Mangifera indica L, used in Cuba for the treatment of immunopathological disorders. Increasing evidence from preclinical studies indicates that Vimang displays antioxidant, antiallergic, analgesic and antiinflammatory actions. The present study investigated the effects of systemic administration of Vimang on behavioural outcomes of neurological function in rats. A single oral administration of Vimang produced an impairment of short- and long-term retention of memory for aversive training when given either 1 h pretraining or immediately posttraining, but not 8 h posttraining. Vimang did not affect open field behaviour or habituation. The results indicate that Vimang might induce deficits of emotionally motivated memory without affecting nonassociative memory, locomotion, exploratory behaviour or anxiety.

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“…Most studies use antioxidants against 1e-oxidants (radicals), which offer little protection against 2e-oxidants (Stocker and Keaney, 2004). Mangifera indica L. extract (Vimang 1 ), composed of a mix of polyphenols, terpenoids, steroids, fatty acids and microelements, present antioxidant action in vitro against 1e-oxidants (hydroxyl radical) and 2e-oxidants (hypochlorous acid) (N uñez-Sell es et al, 2007). In humans, it was reported that Vimang daily ingestion by elderly promoted reductions in serum oxidative stress markers (Pardo-Andreu et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Mangifera indica L. extract (Vimang®) reduces plasma and liver cholesterol and leucocyte oxidative stress in hypercholesterolemic LDL receptor deficient mice

Dorighello

Inada

Paim

et al. 2018

Cell Biology International

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Cardiovascular diseases are major causes of death worldwide. Beyond the classical cholesterol risk factor, other conditions such as oxidative stress are well documented to promote atherosclerosis. The Mangifera indica L. extract (Vimang®) was reported to present antioxidant and hypocholesterolemic properties. Thus, here we evaluate the effects of Vimang treatment on risk factors of the atherosclerosis prone model of familial hypercholesterolemia, the LDL receptor knockout mice. Mice were treated with Vimang during 2 weeks and were fed a cholesterol-enriched diet during the second week. The Vimang treated mice presented significantly reduced levels of plasma (15%) and liver (20%) cholesterol, increased plasma total antioxidant capacity (10%) and decreased reactive oxygen species (ROS) production by spleen mononuclear cells (50%), P < 0.05 for all. In spite of these benefits, the average size of aortic atherosclerotic lesions stablished in this short experimental period did not change significantly in Vimang treated mice. Therefore, in this study we demonstrated that Vimang has protective effects on systemic and tissue-specific risk factors, but it is not sufficient to promote a reduction in the initial steps of atherosclerosis development. In addition, we disclosed a new antioxidant target of Vimang, the spleen mononuclear cells that might be relevant for more advanced stages of atherosclerosis.

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The paradox of natural products as pharmaceuticalsExperimental evidences of a mango stem bark extract

Cited by 44 publications

References 33 publications

Mangiferin Prevents Guinea Pig Tracheal Contraction via Activation of the Nitric Oxide-Cyclic GMP Pathway

Mangiferin Prevents Guinea Pig Tracheal Contraction via Activation of the Nitric Oxide-Cyclic GMP Pathway

Mangifera indica extract (Vimang) impairs aversive memory without affecting open field behaviour or habituation in rats

Mangifera indica L. extract (Vimang®) reduces plasma and liver cholesterol and leucocyte oxidative stress in hypercholesterolemic LDL receptor deficient mice

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