2016
DOI: 10.3233/ch-152014
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The paradox of the serrated sickle erythrocyte: The importance of the red blood cell membrane topography

Abstract: Red blood cell rheology and adhesiveness play a key role in the occurrence of vaso-occlusive like events in sickle cell anemia. The present paper reviews counter-intuitive findings supporting that rigid and serrated sickle red blood cells do not initiate vaso-occlusion. Instead, the less rigid red blood cells could initiate vaso-occlusion because of their increased adhesiveness to the vascular wall. We suspect that stiffness of sickle erythrocytes and the topography of RBC membrane are factors affecting adhesi… Show more

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Cited by 6 publications
(4 citation statements)
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“…Concerning rs2070744 TT, T test -Mean ± standard deviation (n -sample size). 2 Mann-Whitney test -Median; minimum -maximum (n -sample size). results are not unexpected since the corresponding T allele in the promoter region was already reported associated with lower levels of gene expression [22].…”
Section: Discussionmentioning
confidence: 99%
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“…Concerning rs2070744 TT, T test -Mean ± standard deviation (n -sample size). 2 Mann-Whitney test -Median; minimum -maximum (n -sample size). results are not unexpected since the corresponding T allele in the promoter region was already reported associated with lower levels of gene expression [22].…”
Section: Discussionmentioning
confidence: 99%
“…Thus, T test -Mean ± standard deviation (n -sample size). 2 Mann-Whitney test -Median; minimum -maximum (n -sample size). Fig.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…On the other hand in extreme cases of sickle cell crisis, a dramatic near zero flow in cutaneous capillaries can occur [21,24] because of the extremely reduction of the deformability of the sickled erythrocytes [27] together with their adhesiveness [3].…”
mentioning
confidence: 99%