Partisan animosity has been growing in the U.S. and around the world over the past few decades, fueling efforts by researchers and practitioners to help heal the divide. Many studies have been conducted to test interventions that aim to promote open-mindedness; however, these studies have been conducted in disparate literatures that do not always use the same terminology. In this review, we integrate research on open-mindedness in order to facilitate cross-talk and collaboration between disciplines. Moreover, we offer a conceptual model to help guide the further development of interventions and research to understand open-mindedness. We propose that open-mindedness is multi-faceted and dynamic, such that interventions should focus on targeting multiple psychological pathways in order to maximize and sustain their effects. Specifically, we propose that interventions that target cognitive and/or motivational pathways can induce open-mindedness initially. Then, training in emotion regulation and/or social skills can help to sustain and build on open-mindedness once individuals enter into a situation where their beliefs are challenged. We conclude with a discussion of potential future directions for research on open-mindedness interventions.