The paramagnetic and luminescent [Re6Se8I6]3− cluster. Its potential use as an antitumoral and biomarker agent

Studying the Effect of a Composition of the Cluster Core in High-Radiopacity Cluster Complexes of Rhenium on Their Acute Toxicity In Vivo

“…Histological analysis of the liver after injection of Na 4 [{Re 6 S 8 }(CN) 6 ] in a dose of 250 mg/kg(Re)/kg revealed the signs of degenerative changes in hepatocytes, particularly in the area of hepatic triads (Fig. 1, a).…”

“…1, a). The severity of degenerative changes in hepatocytes was lower after injection of Na 4 [{Re 6 Se 8 }(CN) 6 ] in a dose of 500 mg/kg(Re)/ kg (despite greater dose of the study compound; Fig. 1, b).…”

“…In vivo acute toxicity was studied after intravenous injection of the following three octahedral cluster complexes with the same external ligands (CN -), but various internal ligands (S, Se, or Te): Na 4 6 ] in a dose of 500 mg(Re)/kg were injected into the lateral caudal vein of animals. The control group received a sterile aqueous solution of 0.9% NaCl.…”

“…The data were recorded with an AxioCam ICC 1 digital camera and AxioVision Rel.4.8 software (Carl Zeiss). 6 ] complex to 250 mg(Re)/kg, three mice survived until the end of observations, and one mice died over the 1st day after injection.…”

“…The luminescent and photosensitizing properties suggest that these complexes can serve as biomarkers in biology, as well as photosensitizing agents for photodynamic therapy of malignant neoplasms. However, the biological effects of these compounds on in vitro and in vivo models were evaluated only in recent years [1,4,6]. Hence, the effects of various cluster complexes on animal cells and body should be studied in details for their introduction into medical practice.…”