The Parasite Trichospirura leptostoma Associated with Wasting Disease in a Colony of Common Marmosets, Callithrix jacchus

Beglinger, R; Illgen, B.; Pfister, Rudolf; Heider, Katharina

doi:10.1159/000156355

Cited by 22 publications

(13 citation statements)

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“…While often referred to as 'marmoset wasting disease', this term should be avoided as it has been linked to several distinct etiologies including protein deficiency (Brack and Rothe, 1981), food allergens (Gore et al, 2001) and chronic parasitism (Beglinger et al, 1988). While often referred to as 'marmoset wasting disease', this term should be avoided as it has been linked to several distinct etiologies including protein deficiency (Brack and Rothe, 1981), food allergens (Gore et al, 2001) and chronic parasitism (Beglinger et al, 1988).…”

Section: Nutritionmentioning

confidence: 99%

Nonhuman Primates

Magden

Mansfield²,

Simmons

et al. 2015

Laboratory Animal Medicine

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Section: Nutritionmentioning

confidence: 99%

Nonhuman Primates

Magden

Mansfield²,

Simmons

et al. 2015

Laboratory Animal Medicine

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“…The gold standard for diagnosing MWS is through postmortem histologic examination of tissues, with chronic lymphoplasmacytic enterocolitis being the hallmark lesion [6], [8], [10], [12], [13], [15], [16]. Several etiologies for MWS have been proposed, including food allergies [17], [18], parasitism [19], [20], and autoimmune disease [21], but the cause of the condition remains unknown. Unfortunately there are no consistently effective treatments for halting the progression of or reversing the disease process, and due to a lack of proven antemortem diagnostic tools, affected marmosets are often not identified until the terminal stage of disease, at which point they are often already enrolled in research studies or breeding programs.…”

Section: Introductionmentioning

confidence: 99%

Serum Albumin and Body Weight as Biomarkers for the Antemortem Identification of Bone and Gastrointestinal Disease in the Common Marmoset

et al. 2013

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The increasing use of the common marmoset (Callithrix jacchus) in research makes it important to diagnose spontaneous disease that may confound experimental studies. Bone disease and gastrointestinal disease are two major causes of morbidity and mortality in captive marmosets, but currently no effective antemortem tests are available to identify affected animals prior to the terminal stage of disease. In this study we propose that bone disease and gastrointestinal disease are associated disease entities in marmosets and aim to establish the efficacy of several economical antemortem tests in identifying and predicting disease. Tissues from marmosets were examined to define affected animals and unaffected controls. Complete blood count, serum chemistry values, body weight, quantitative radiographs, and tissue-specific biochemical markers were evaluated as candidate biomarkers for disease. Bone and gastrointestinal disease were associated, with marmosets being over seven times more likely to have either concurrent bone and gastrointestinal disease or neither disease as opposed to lesions in only one organ system. When used in tandem, serum albumin <3.5 g/dL and body weight <325 g identified 100% of the marmosets affected with concurrent bone and gastrointestinal disease. Progressive body weight loss of 0.05% of peak body weight per day predicted which marmosets would develop disease prior to the terminal stage. Bone tissue-specific tests, such as quantitative analysis of radiographs and serum parathyroid hormone levels, were effective for distinguishing between marmosets with bone disease and those without. These results provide an avenue for making informed decisions regarding the removal of affected marmosets from studies in a timely manner, preserving the integrity of research results.

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“…The cause of WMS has also been assigned to infections [21]. Beglinger et al [5] concluded that a massive infestation of the parasite Trichospirura leptostoma and the resulting pancreatic insufficiency were the causes of WMS in their colony of C. jacchus. The order of events is not clear from the study, however.…”

Section: Introductionmentioning

confidence: 99%

Callitrichid nutrition and food sensitivity

Gore

Brandes

Kaup

et al. 2001

J of Medical Primatology

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Captive callitrichids are prone to developing intestinal problems. Their captive and natural diets differ enormously, and diet has been suggested to play a major role in wasting marmoset syndrome. Proteins in wheat, soy and milk are included in callitrichid diets of most colonies and have been linked to an immune reaction in Saguinus oedipus and Callithrix jacchus. In the present study of 23 males and females of the two species, wheat protein was tested but soy and milk products were excluded. One group had wheat and the other had rice in their diet. Blood samples and biopsies from the colon were taken. Results showed changes in the colon and an immune reaction to gliadin, a wheat protein related to coeliac disease in humans. A further immune reaction was also observed. Suggestions for further study and exclusion of cereal in the diet of these small, New World primates are discussed.

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The Parasite Trichospirura leptostoma Associated with Wasting Disease in a Colony of Common Marmosets, Callithrix jacchus

Cited by 22 publications

References 0 publications

Nonhuman Primates

Nonhuman Primates

Serum Albumin and Body Weight as Biomarkers for the Antemortem Identification of Bone and Gastrointestinal Disease in the Common Marmoset

Callitrichid nutrition and food sensitivity

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