The Parathyroid Glands and Phosphorus Homeostasis 12

Crawford, John D.; Osborne, Maurice M.; Talbot, Ńathan B.; Terry, Mary L.; Morrill, Mary F.

doi:10.1172/jci102385

Cited by 93 publications

(16 citation statements)

References 21 publications

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“…The attempt to correlate TmP with the dietary level of Ca and P in our studies has been inconclusive. A correlation between the level of phosphate in the diet and phosphate reabsorption has been demonstrated in rats (16), dogs (17) and newborn infants (18). A high level of P intake was associated with a reduction in P reabsorption.…”

Section: Discussionmentioning

confidence: 93%

Renal Reabsorption of Phosphate in Normal Human Subjects and in Patients with Parathyroid Disease

Thompson¹,

Hiatt²

1957

J. Clin. Invest.

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A number of studies in the dog and in man (1-6) have demonstrated a maximal renal tubular reabsorptive capacity for phosphate (TmP 8). However, some investigators have denied that the reabsorption of phosphate conforms to Tm characteristics (7-9). These workers have suggested that phosphate reabsorption is conditioned by the rate of phosphate filtration such that a fairly constant proportion of the filtered phosphate is reabsorbed. In view of the conflicting evidence and the relative paucity of phosphate titration studies on man, experiments were performed in order to obtain information on the mechanism of phosphate reabsorption, the constancy of reabsorption in any one individual, and its variability in a group of subjects. The data were required for subsequent investigations designed to evaluate the influence of several factors on renal phosphate transport. The studies were performed on normal individuals and in patients with parathyroid disease.It was found that in any given experiment a TmP was demonstrable. However, the variability in TmP seen in most of our normal subjects between consecutive periods of a single experiment and between experiments generally exceeded the variability reported for glucose Tm and for PAH Tm. Furthermore, the range of values for TmP within a group of normal individuals is so large that an average value has little meaning. Fluctuations in TmP in our subjects could not be con- All subjects were hospitalized on a metabolism ward, and during many of the studies they received constant diets of calculated calcium and phosphate content There were no restrictions on the patients' activities.Design of experiments. Studies were begun about 9 a.m. with the patient fasted for 12 to 16 hours. Onehalf hour prior to the start of each study the subject ingested a liter of water and thereafter drank 200 ml. of wa-

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Section: Discussionmentioning

confidence: 93%

Renal Reabsorption of Phosphate in Normal Human Subjects and in Patients with Parathyroid Disease

Thompson¹,

Hiatt²

1957

J. Clin. Invest.

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“…Crawford, Osborne, Talbot, Terry and Morrill (21) have shown that the TRP is a more sensitive index of parathyroid function than the absolute rate of phosphate reabsorption: the TRP has an essentially constant high value in parathyroidectomized animals and promptly decreases when parathyroid extract is administered. The impressive increase of the TRP during and following the calcium infusions may therefore be related to decreasing parathyroid function.…”

Section: Resultsmentioning

confidence: 99%

Vitamin D-Resistant Rickets: The Effect of Calcium Infusion on Phosphate Reabsorption *

Field¹,

Reiss²

1960

J. Clin. Invest.

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“…declines gradually after phosphate administration and tends to reach a minimum value after 7-10 hr. According to Crawford et al (1950), the value of T.R.P./G.F.P. is an inverse index of parathyroid activity and is accentuated by phosphate loading.…”

Section: Serum Phosphate and Calcium 27mentioning

confidence: 99%

Seasonal variations in serum inorganic phosphate and calcium with special reference to parathyroid activity

Iwanami¹,

Osiba²,

Yamada³

et al. 1959

The Journal of Physiology

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The Parathyroid Glands and Phosphorus Homeostasis 12

Cited by 93 publications

References 21 publications

Renal Reabsorption of Phosphate in Normal Human Subjects and in Patients with Parathyroid Disease

Renal Reabsorption of Phosphate in Normal Human Subjects and in Patients with Parathyroid Disease

Vitamin D-Resistant Rickets: The Effect of Calcium Infusion on Phosphate Reabsorption *

Seasonal variations in serum inorganic phosphate and calcium with special reference to parathyroid activity

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