The participation of the carbonates of bone in the neutralization of ingested acid

Serial Changes in Tissue Carbon Dioxide Content During Acute Respiratory Acidosis12

“…They have also shown that the C03= content of synthetic apatites varies directly with the HCO3-concentration in the surrounding fluids at constant pH (28). Evidence is also available that bone CO2 content varies directly with extracellular pH (29,30). In metabolic acidosis and alkalosis these two parameters vary in parallel fashion, and, therefore, it is impossible to distinguish the effect of one from the other upon bone carbonate concentration.…”

“…cause the release of mineral salts from bone (29,30) and, therefore, values for bone CO2, expressed in terms of the dry solids of bone, might be misleading due to changes in the ratio between organic and mineral solids in certain of the animals.…”

The Participation of Bone in Total Body Sodium Metabolism in the Rat 1

“…Irving and Chute (21) found a reduction in bone carbonate following acute oral HC1 loads. Burns (22) reported that prolonged feeding of 0.1 normal HC1 (12 to 100 ml.…”

The effects of chronic acid loads in normal man: further evidence for the participation of bone mineral in the defense against chronic metabolic acidosis.

“…Albright and Reifenstein (8) assumed that the calcium losses in acidosis were derived from bone salts in the same proportion as these salts existed in whole bone and thus calculated that 0.49 mEq of acid would be neutralized for each milliequivalent of calcium lost. However, direct measurements of the alterations in bone composition during relatively acute experimental metabolic acidosis in animals (9) indicate that CaCO3 is the principal calcium salt lost. In more prolonged acidosis occurring during the course of chronic renal disease in man, it is clear that the total mineral mass of the skeleton is reduced, but even in this circumstance disproportionate losses of carbonate from bone have been reported (10 The constant whole food diets used in these experiments provided a significant quantity of potential alkali as combustible anions, and during acid loading the fecal excretion of organic anions declined significantly.…”