The partition coefficient of aminouracil derivatives.

Inoue, Sho; Ogino, Akio; Kise, Masahiro; Kitano, Masahiko; Tsuchiya, Sumie; Fujita, Toshio

doi:10.1248/cpb.22.2064

Cited by 4 publications

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“…Biosynthesis of "normal" flavonoids and their glycosylated derivatives involves three acetate units (ring A) and phenylalanine (ring B and the C3 segment) as shown by in vivo and in vitro tracer studies (see reviews by HAHLBROCK and GRISEBACH [17], HAHLBROCK [18]). In the case of Cglycosyl flavonoid aglycones, participation of phenylalanine and p-coumaric acid in ring B and C formation has been established [19,20].…”

Section: Biosynthesis Of C-glycosyl Flavonoidsmentioning

confidence: 99%

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Chemistry, Occurrence and Biosynthesis ofC-Glycosyl Compounds in Plants

Franz

Grün

1983

Planta Med

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compounds with glucuronic acid have been found in mammals, which are probably analogous to C-glycosylated compounds in plants. C-Glucuronides of drugs in man [10] and other mammals [11, 12] represent a novel type of drug metabolite. As regards the biosynthetic pathway which leads to the formation of the carbon-carbon bond in C-glycosides, very little is known. In some cases it is thought that the attachment of the sugar moiety takes place during an early stage of the aglycone formation but definite proof is still missing and cannot be generalized for all groups of the C-glycosides. The aim of this article is to present a short review of the principal structural features and occurrence of the different classes of C-glycosides and further, to discuss the few biosynthetic findings of the C-glycosyl attachment which have been published so far. C-Glycosyl Flavonoids Chemistry of C-glycosyl Flavonoids As it has been pointed out, this group of C-glycosides has been the subject of a still increasing number of reports, which mainly deal with the occurrence and structural investigation of these compounds. Since they have been the subject of several review articles [3, 6, 7, 13, 14] only the main features are given here. At the present over one hundred C-glycosyl flavonoids have been shown to exist in the plant kingdom. The model compound and one of the first to be isolated was vitexin (8-C-3-D-glucopyranosylapigenm) (Fig. 2), the structure of which was established

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Section: Biosynthesis Of C-glycosyl Flavonoidsmentioning

confidence: 99%

“…Proposed pathway for the biosynthesis of mangifenn via maclurin after[19,25]. tetrahydroxyxanthone and the benzophenone maclurin to Anemarrhena asphodeloides and…”

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Chemistry, Occurrence and Biosynthesis ofC-Glycosyl Compounds in Plants

Franz

Grün

1983

Planta Med

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Free Wilson Analysis. Theory, Applications and its Relationship to Hansch Analysis

Kubinyi¹

1988

Quant. Struct.‐Act. Relat.

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The Free Wilson model is a simple and efficient method for the quantitative description of structure activity relationships. It is the only numerical method which directly relates structural features with biological properties, in contrast to Hansch analysis, where physicochemical properties are correlated with biological activity values. Nevertheless both approaches are closely interrelated, not only from a theoretical point of view, but also in their practical applicability. In many cases both models can be combined to a mixed approach which includes Free Wilson type parameters to describe the activity contributions of certain structural modifications and physicochemical parameters to describe the effect of some other substituents on the biological activity. Many successful applications, especially from the work of Hansch and his group on the structure activity relationships of enzyme inhibitors, demonstrate that this combined model is the most powerful tool of classical QSAR.

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Recent Advances in Biochemical QSAR

Hansch

1978

Correlation Analysis in Chemistry

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The partition coefficient of aminouracil derivatives.

Cited by 4 publications

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Chemistry, Occurrence and Biosynthesis ofC-Glycosyl Compounds in Plants

Chemistry, Occurrence and Biosynthesis ofC-Glycosyl Compounds in Plants

Free Wilson Analysis. Theory, Applications and its Relationship to Hansch Analysis

Recent Advances in Biochemical QSAR

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