The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy

Abstract

Alzheimer's disease (AD), a progressive neurodegenerative disease characterized by cognitive dysfunction and neuropsychiatric symptoms, is the most prevalent form of dementia among the elderly. Amyloid aggregation, tau hyperphosphorylation, and neural cell loss are the main pathological features. Various hypotheses have been proposed to explain the development of AD. Some therapeutic agents have shown clinical benefits in patients with AD; however, many of these agents have failed.The degree of neural cell loss is associated with the severity of AD. Adult neurogenesis, which governs cognitive and emotional behaviors, occurs in the hippocampus, and some research groups have reported that neural cell transplantation into the hippocampus improves cognitive dysfunction in AD model mice. Based on these clinical findings, stem cell therapy for patients with AD has recently attracted attention.This review provides past and present therapeutic strategies for the management and treatment of AD.

Intestinal flora study reveals the mechanism of Danggui Shaoyao San and its decomposed recipes to improve cognitive dysfunction in the rat model of Alzheimer’s disease

“…The pathogenesis of AD is multifactorial and not well understood. The mainstream hypothesis, the amyloid-b (Ab) hypothesis, has led to the development of drugs that have only reached clinical trials without success (Sun et al, 2018;Murayama, 2023). The gut microbiota plays a role in the pathogenesis of AD and is involved in the cognitive and AD-related mechanisms in the host.…”