The pathogenesis of aging-induced left atrial appendage thrombus formation and cardioembolic stroke in mice is influenced by inflammation-derived matrix metalloproteinases

Tan, Ruopeng; Yuan, Mengyang; Wang, Lin; Liu, Jingjie; Jiang, Guinan; Liao, Jiawei; Yin, Xiaomeng; Liu, Yang

doi:10.1016/j.thromres.2023.04.020

Thrombosis Research

2023

DOI: 10.1016/j.thromres.2023.04.020

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The pathogenesis of aging-induced left atrial appendage thrombus formation and cardioembolic stroke in mice is influenced by inflammation-derived matrix metalloproteinases

Ruopeng Tan

Mengyang Yuan

Lin Wang

et al.

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2024

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Cited by 1 publication

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Causal effect of serum matrix metalloproteinase levels on venous thromboembolism: a Mendelian randomization study

Han,

Yu,

Zheng

2024

Epidemiol Health

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OBJECTIVES Serum matrix metalloproteinase (MMP) levels are associated with cardiovascular diseases. However, the causal associations between serum levels of specific MMPs and venous thromboembolism (VTE) remain unclear. The present study sought to explore the causal relationship between serum MMP levels and VTE by using the Mendelian randomization (MR) method. METHODS In this study 2-sample MR study, the exposure data on serum MMP levels were derived from genome-wide association studies involving 21,758 individuals from 13 cohorts of European descent. The outcome data on VTE, including deep vein thrombosis and pulmonary embolism, were derived from the FinnGen research project. The primary method used was the inverse-variance weighting method. The MR-Egger intercept test and the Cochran Q test were used to evaluate pleiotropy and heterogeneity. RESULTS Using the inverse-variance weighting method, higher serum MMP-12 levels were found to be associated with an increased risk of VTE (odds ratio, 1.04; 95% confidence interval, 1.01 to 1.07; p=0.001). Moreover, there was a weak association between the levels of certain MMPs and VTE. Sensitivity analyses revealed no significant heterogeneity and pleiotropy in our study, and the Steiger directionality test did not reveal a significant reverse causation association. CONCLUSIONS There is a causal association between MMP-12 levels and VTE, which may have substantial implications for the diagnostic and therapeutic strategies used for VTE.

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Causal effect of serum matrix metalloproteinase levels on venous thromboembolism: a Mendelian randomization study

Han,

Yu,

Zheng

2024

Epidemiol Health

View full text Add to dashboard Cite

show abstract

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The pathogenesis of aging-induced left atrial appendage thrombus formation and cardioembolic stroke in mice is influenced by inflammation-derived matrix metalloproteinases

Cited by 1 publication

References 47 publications

Causal effect of serum matrix metalloproteinase levels on venous thromboembolism: a Mendelian randomization study

Causal effect of serum matrix metalloproteinase levels on venous thromboembolism: a Mendelian randomization study

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