The Pathogenesis of Cytomegalovirus and Other Viruses Associated with Hearing Loss: Recent Updates

Shi, Xinyu; Liu, Xiaozhou; Sun, Yu

doi:10.3390/v15061385

Cited by 6 publications

(2 citation statements)

References 250 publications

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“…The SARS-CoV-2 infection, of the Coronavirus family could, could lead to several malfunctioning in the upper respiratory tract. The affiliation between SARS-CoV-2 and sudden sensorineural HL (SSNHL) has been detailed in several case instances, numerous SARS-CoV-2 varieties can result in ontological symptoms [21]. Unfortunately, high quality data on the prevalence of hearing loss before and after the pandemic is limited.…”

Section: Introductionmentioning

confidence: 99%

Regional Profiling for the Frequency, Patterns, and Factors of Hearing Loss Reveals Genetics, Geriatric Age, and Noise Hazard as Major Predispositions

D.Alotaibi,

Said,

Ahmed

et al. 2024

Preprint

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Hearing loss (HL) is a major clinical, population and public health leading to serious disorders and often early mortality. However, there is a significant paucity in high quality data. Saudi Arabia has a genetically uniform and young population; however factors and estimates on prevalence of HL remains unknown. Background/Objectives: we aimed to determine the frequency, factors, and patterns of HL in different regions. Methods: this study was a descriptive cross-sectional design using a web-based online public questionnaire sent out simultaneously to different regions of Saudi Arabia; namely Eastern, Western, Northen, and Southern as self-administered non-probability sample of social media users mainly WhatsApp, Twitter, and others. Results: Among 789 responses, 6.6 % reported HL, 62.4% were from the Eastern province of which 41.2% were employed and 31.7% were students. Many (36.5%) reported HL &gt; 5-years while 21.2% had programmed and fitted with hearing aids or cochlear implants implying negligence. 19.2% reported diabetes and 51.9% had family history. Ages (11– 50 years) were examined with a slight female predominance (females 59.1%, males 41%). Age was significantly associated with HL (P &lt;0.001) irrespective of gender (males 6.8%, females 6.4%, P value =0.838) reaching peaks at 17.2% in age groups 51-60 years and 25% in 71-80 indicating a risk for HL (OR = 1.43, 95% CI: 0.78-2.81, p = 0.032). Genetic diseases reported as leading cause in 34.6% (OR = 2.23, 95% CI: 1.34-3.58, p = 0.432) followed by noise (26.9%), while other factors including infections, stroke, and fevers made 19.2%. Work involving air or sea travels reported (7.7%) with no significant association (P = 0.628) while history of head injury or trauma (11.5%), or relocation between low- and high-altitudes showed 21.2%. However, frequent noise pollution (OR = 1.54, 95% CI: 0.83-3.01, p = 0.048), regular use of medications (OR = 2.15, 95% CI: 1.03-3.32, p = 0.017), and history of inflammatory disorders (OR = 0.72, 95% CI: 0.32-1.87, p = 0.229) were also associated with higher odds of HL. Conclusion: thus, these findings have significant clinical implications in early diagnosis and management of HL in genetic disorders, diabetes, geriatrics, as well as awareness on family history and occupational health and safety. The study was limited in size and use of online questionnaires. Future large cohort multicenter study would gain more insights.

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Section: Introductionmentioning

confidence: 99%

Regional Profiling for the Frequency, Patterns, and Factors of Hearing Loss Reveals Genetics, Geriatric Age, and Noise Hazard as Major Predispositions

D.Alotaibi,

Said,

Ahmed

et al. 2024

Preprint

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show abstract

“…SSNHL has a multifactorial etiology whose pathophysiologic mechanism remains unclear. The cause may be associated with cochlear membrane injury ( 11 ), microarteriosclerosis ( 12 ), microthrombosis ( 13 ), viral infections ( 14 ), autoimmunity ( 15 ), metabolic diseases ( 16 ) and other risk factors. The effect of these processes, which can even occur simultaneously, leads to inflammatory and metabolic changes that can affect the cochlear microenvironment or its nervous component.…”

Section: Introductionmentioning

confidence: 99%

The inflammatory and metabolic status of patients with sudden-onset sensorineural hearing loss

do Amaral,

Peron,

Soeiro

et al. 2024

Front. Neurol.

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IntroductionSudden sensorineural hearing loss (SSNHL) is a common emergency symptom in otolaryngology that requires immediate diagnosis and treatment. SSNHL has a multifactorial etiology, and its pathophysiologic mechanisms may be associated with inflammatory and metabolic changes that may affect the cochlear microenvironment or its nervous component, thus triggering the process or hindering hearing recovery. Therefore, the aim of this study was to assess metabolic and inflammatory changes to identify systemic parameters that could serve as prognostic factors for hearing recovery in patients with SSNHL.Materials and methodsThirty patients with a sudden hearing loss of at least 30 dB in three contiguous frequencies were enrolled in this study. Patients were followed up for 4 months and peripheral blood samples were collected at 7 days (V1), 30 days (V2) and 120 days (V3). Interleukins (IL)-1F7, IL-2, IL-4, IL-5, IL-6, IL-10, interferon γ (IFN-γ), tumor necrosis factor α (TNF-α) and adiponectin were quantified in serum. In addition, lipid and glycemic profiles as well as concentration of creatinine, uric acid, fructosamine, peroxide, total proteins and albumin were analyzed. Patients underwent weekly ear-specific hearing tests with standard pure tone thresholds for frequencies of 250–8,000 Hz, speech recognition threshold and word recognition score.ResultsPatients with SSNHL were divided into a group of patients who did not achieve hearing recovery (n = 14) and another group who achieved complete and significant recovery (n = 16). Most serologic parameters showed no significant changes or values indicating clinical changes. However, IFN-γ levels decreased by 36.3% between V1 and V2. The cytokine TNF-α showed a statistically significant decrease from V1 to V3 (from 22.91 to 10.34 pg./mL). Adiponectin showed a decrease from 553.7 ng/mL in V1 to 454.4 ng/mL in V3.DiscussionOur results show that serologic cytokine levels change in the acute phase of manifestation of SSNHL and establish a parallel between systemic changes and improvements in hearing, especially TNF-α, which showed differences in hearing recovery. The use of IFN-γ, TNF-α and adiponectin may elucidate the clinical improvement in these patients.

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Risk factors associated with late-onset hearing loss in children with congenital cytomegalovirus: a systematic review

Fernández-Rueda,

Calvo-Henriquez,

Fernández-Liesa

et al. 2024

Eur Arch Otorhinolaryngol

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The Pathogenesis of Cytomegalovirus and Other Viruses Associated with Hearing Loss: Recent Updates

Cited by 6 publications

References 250 publications

Regional Profiling for the Frequency, Patterns, and Factors of Hearing Loss Reveals Genetics, Geriatric Age, and Noise Hazard as Major Predispositions

Regional Profiling for the Frequency, Patterns, and Factors of Hearing Loss Reveals Genetics, Geriatric Age, and Noise Hazard as Major Predispositions

The inflammatory and metabolic status of patients with sudden-onset sensorineural hearing loss

Risk factors associated with late-onset hearing loss in children with congenital cytomegalovirus: a systematic review

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