The pathogenesis of dermatitis herpetiformis: Recent advances

Hall, Russell P.

doi:10.1016/s0190-9622(87)70148-0

Cited by 89 publications

(22 citation statements)

References 104 publications

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“…Indirect immunofluorescence with LABD sera was performed with both monkey esophagus and saline-split normal human skin as substrates and developed with both fluorescein-conjugated anti-IgA and anti-IgG. No (20). It should also be noted that all patients showed at least a one-tube dilution greater titer when salinesplit skin was used as a tissue source.…”

Section: Resultsmentioning

confidence: 99%

Identification of the cutaneous basement membrane zone antigen and isolation of antibody in linear immunoglobulin A bullous dermatosis.

Zone

Taylor²,

Kadunce³

et al. 1990

J. Clin. Invest.

259

157

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Linear IgA bullous dermatosis (LABD) is a rare blistering skin disease characterized by basement membrane zone deposition of IgA. This study identifies a tissue antigen detected by patient serum and then isolates the autoantibody using epidermis and protein bands blotted on nitrocellulose as immunoabsorbents.Sera from 10 patients (9 with cutaneous disease and 1 with cicatrizing conjunctivitis) were evaluated. Indirect immunofluorescence revealed an IgA anti-basement membrane antibody in 6 of 10 sera with monkey esophagus substrate and 9 of 10 sera with human epidermal substrate. Immunoblotting was performed on epidermal and dermal extracts prepared from skin separated at the basement membrane zone with either sodium chloride or EDTA. Saline-separated skin expressed a 97-kD band in dermal extract alone that was recognized by 4 of 10 sera. EDTA-separated skin expressed the 97-kD band in both epidermal (4 of 10 sera) and dermal (6 of 10 sera) extract. Immunoabsorption of positive sera with epidermis purified an IgA antibody that reacted uniquely with the 97-kD band. In addition, IgA antibody bound to nitrocellulose was eluted from the 97-kD band and found to uniquely bind basement membrane zone.

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Section: Resultsmentioning

confidence: 99%

Identification of the cutaneous basement membrane zone antigen and isolation of antibody in linear immunoglobulin A bullous dermatosis.

Zone

Taylor²,

Kadunce³

et al. 1990

J. Clin. Invest.

259

157

View full text Add to dashboard Cite

show abstract

“…For lamina propria, the mean and SEM for the cell density are given in parentheses. (18), in which case the y/6+ cells might play no role in the pathogenesis of villous atrophy of celiac disease. This is advocated by the absence of y/6+ cells in other forms of diseases with villous atrophy, as shown in patients with tropical sprue (6) and in the food allergy case of this study, and by their abundance in morphologically normal jejunal specimens of patients with dermatitis herpetiformis on a normal gluten-containing diet (19).…”

Section: Controls Rectummentioning

confidence: 99%

Intestinal γ/δ Receptor-Bearing T Lymphocytes in Celiac Disease and Inflammatory Bowel Diseases in Children. Constant Increase in Celiac Disease

1990

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ABSTRACT. We studied the numbers of T-cell receptor alb-and 716-bearing lymphocytes in 27 jejunal specimens from 19 celiac patients, 27 rectal and colonic specimens from 14 ulcerative colitis patients and four patients with Crohn's disease, and 24 control specimens. MAb and a three-layer peroxidase staining method were used. Only low numbers of 7/6+ cells were seen in normal jejunum and rectum of controls, as well as in the specimens of patients with inflammatory bowel diseases. In the lamina propria of celiac patients, the mean number of 7/6+ cells was significantly higher than in the controls before treatment, during gluten-free diet, and after the gluten challenge. Within the jejunal epithelium, the number of 7/6+ cells was elevated before and during gluten elimination and after the challenge test. The absolute number of intraepithelial 7/6+ cells remained constant during gluten elimination and provocation. We infer that the constantly elevated population of y/6+ T cells in the epithelium of celiac patients may play an important role in the pathogenesis of celiac disease. (Pediatv Res 28: 579-581, 1990)

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“…DH is considered to be the skin disease most specifically related to gluten-sensitive enteropathy indistinguishable from coeliac disease [1, 2]. Circulating IgA anti-endomysium and anti-tissue-transglutaminase antibodies are detected both in DH and in coeliac disease; these antibodies are directly related to the degree of intestinal damage and are important indicators of the subject’s adherence to the gluten-free diet [3].…”

Section: Introductionmentioning

confidence: 99%

Serum Eosinophil Cationic Protein, Myeloperoxidase, Tryptase, Eotaxin and Th2-Like Cytokines in Dermatitis herpetiformis

Caproni

Cardinali²,

A³

et al. 2002

Int Arch Allergy Immunol

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Background: Dermatitis herpetiformis (DH) is a subepidermal bullous disease characterized by a neutrophilic and eosinophilic infiltrate, together with activated lymphocytes that show preferential polarization towards the Th2-like phenotype. To date, the role of neither soluble mediators, such as cytokines, nor serum levels of myeloperoxidase (MPO), eosinophil cationic protein (ECP) and tryptase (TRY) have been studied in the peripheral blood of DH. In this study we investigated 40 DH subjects for possible alterations in MPO, ECP, TRY, eotaxin, interleukin (IL) 4 and IL-5 concentrations to evaluate the role of neutrophils, eosinophils and mast cells in the induction of skin lesions. Sera from 20 healthy subjects were tested as controls. Methods: Eotaxin, IL-4 and IL-5 serum contents were determined by a solid-phase enzyme-linked immunosorbent assay. A double antibody radioimmunoassay was used to measure serum levels of MPO, ECP and TRY. Results: Normal levels of eotaxin and IL-4 were found in all DH subjects; increased IL-5 levels were found only in 1 subject. The MPO levels were significantly higher in DH subjects than in healthy controls (p < 0.01). There was also a significant difference between the serum ECP levels of DH and healthy controls (p < 0.05). TRY was not revealed in the serum of DH subjects. Conclusions: The determination of Th2-like cytokines and TRY serum levels is not important in quantifying the involvement of activated lymphocytes and mast cells in DH; however, the finding of high MPO and ECP serum levels seems to confirm that these products are good markers of the presence of activated neutrophils and eosinophils.

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The pathogenesis of dermatitis herpetiformis: Recent advances

Cited by 89 publications

References 104 publications

Identification of the cutaneous basement membrane zone antigen and isolation of antibody in linear immunoglobulin A bullous dermatosis.

Identification of the cutaneous basement membrane zone antigen and isolation of antibody in linear immunoglobulin A bullous dermatosis.

Intestinal γ/δ Receptor-Bearing T Lymphocytes in Celiac Disease and Inflammatory Bowel Diseases in Children. Constant Increase in Celiac Disease

Serum Eosinophil Cationic Protein, Myeloperoxidase, Tryptase, Eotaxin and Th2-Like Cytokines in Dermatitis herpetiformis

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