The pathogenesis of Hodgkin's disease

Stuart, A. E.

doi:10.1002/path.1711260408

Cited by 14 publications

(2 citation statements)

References 67 publications

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“…An alternative possibility is that T4+ cytolytic lymphocytes utilize their killing machinery against cell types other than R-S cells (or their morphologically normal cell precursors). Previous hypotheses have indeed suggested that a "civil war" among lymphocytes can occur in patients with HD, which could eventually result in the development of neoplastic cells (Smithers, 1973;Stuart, 1978). Our present results do not allow any definite conclusions to be drawn regarding this possibility, even though T4+ cytolytic clones derived from HD spleens were found to be devoid of cytotoxic activity against autologous T-cell blasts.…”

Section: Discussioncontrasting

confidence: 81%

Clonal analysis of T lymphocytes in spleens from patients with Hodgkin's disease. Frequent occurrence of unusual T4‐positive cells which co‐express cytolytic activity and production of interleukin‐2

Romagnani¹,

Maggi²,

Parronchi³

et al. 1986

Intl Journal of Cancer

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T-lymphocyte populations isolated from spleens of untreated patients with Hodgkin's disease (HD) were grown by combining limiting dilution techniques and an assay system that allows clonal proliferation of virtually all human T cells. Under these conditions, high proportions of splenic T lymphocytes (50-80%) underwent clonal expansion, so that the set of clones obtained could be considered representative of the starting T-cell population. A total number of 229 clones from 6 HD spleens (3 uninvolved and 3 histologically involved by the disease) and 133 clones from 3 control spleens (obtained from otherwise healthy individuals, who underwent post-traumatic splenectomy) were examined for surface markers and tested in functional assays. One hundred and seventy-five clones from HD spleens and 75 clones from control spleens expressed the "helper/inducer" (T3+ T4+ T8-)phenotype, whereas as 54 clones from HD spleens and 58 control clones expressed the "cytotoxic/suppressor" (T3+T4-T8+) phenotype. As assessed by a non-specific lectin-dependent lytic assay, the proportion of HD clones displaying cytolytic activity was higher than that of cytolytic clones derived from control spleens. The majority of T4+ clones obtained from HD spleens (either uninvolved or histologically involved by the disease) were cytolytic, whereas only a small proportion (less than 10%) of T4+ clones derived from normal peripheral blood or spleens displayed cytolytic activity. The cytolytic potential of T4+ clones obtained from HD spleens did not reflect the activity of natural killer (NK) cells, since a minority of these clones exerted NK activity on K562 target cells. In addition, most of the T4+ cytolytic clones derived from HD spleens produced particularly high amounts of interleukin-2 (IL-2). These data indicate that T lymphocytes which concentrate in spleens of patients with HD consist at least in part of an infrequent T4+ cell subset co-expressing cytolytic activity and production of IL-2. These cells may reflect a cytotoxic reaction against unknown antigens associated with self class-II histocompatibility antigens.

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Section: Discussioncontrasting

confidence: 81%

Clonal analysis of T lymphocytes in spleens from patients with Hodgkin's disease. Frequent occurrence of unusual T4‐positive cells which co‐express cytolytic activity and production of interleukin‐2

Romagnani¹,

Maggi²,

Parronchi³

et al. 1986

Intl Journal of Cancer

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“…It is generally accepted that the mononuclear Hodgkin's cell (identified in part by the distinctive nucleolus) and Reed-Sternberg cells represent the malignant component of the lesion. However, the progenitor cell giving rise to the neoplasm is disputed, with evidence supporting both their lymphoid (Tindle, Parker & Lukes 1972, Dorfman et al 1973, Glick et al 1976and Glick, Bennett & Collins 1980, Hayhoe et al 1978, Stuart 1978, Taylor 1978 and their monocytic origin (Kaplan 1976, 1981, Kaplan & Gartner 1977, Curran & Jones 1978b, Kadin et al 1978, Peiper et al and commentaries 1980see also Payne et al 1980, Desforges, Rutherford & Piro 1980. Roberts et al (1978) showed in cloned tissue cultures of Hodgkin's cells that they may have both lymphoid and macrophage qualities.…”

Section: Discussionmentioning

confidence: 99%

Lectin staining of carbohydrates of haemic cells. III. The cells of Hodgkin's disease and other lymphomas

1982

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When stained for reactive sialyl groups with fluorescein-labelled Aprotinin (FLA), lymphocytes of three diffuse lymphomas were uniformly faintly fluorescent. The nodules of a nodular lymphocytic lymphoma showed dimly fluorescing lymphocytes surrounded by brightly fluorescing, apparently normal cells. The spleens of eight patients with Hodgkin's disease showed involvement in six cases. With FLA, the two uninvolved spleens contained only brightly fluorescing lymphocytes, whereas the foci of Hodgkin's lesions in the six spleens and in eight involved lymph nodes from a further eight patients contained varying proportions of brightly and dimly fluorescing lymphoid cells. Mononuclear Hodgkin's cells and bi- or multinucleated Reed-Sternberg cells fluoresced faintly. Fluorescein-labelled Ricinus communis agglutinin (FL-RCA) for galactose, and Concanavalin A (FL-Con A) for mannose or glucose, showed eosinophils, reticulin and collagen fibres especially in nodular sclerosing Hodgkin's disease, whereas all lymphocytes, Hodgkin and Reed-Sternberg cells stained faintly with either lectin. The reduction of reactive sialyl groups in malignant lymphocytes of lymphomas and Hodgkin's lesions is similar to that in lymphocytic leukaemias. It is suggested that in Hodgkin's disease these lymphocytes together with the Hodgkin and Reed-Sternberg cells represent the malignant component, whereas the brightly fluorescent normal lymphocytes, together with histiocytes, eosinophils (and neutrophils) represent a reactive component in the lesions. Similarly, the reactive lymphocytes in sarcoid lesions and sinus histiocytosis were brightly fluorescing.

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Mycosis fungoides associated with nodular sclerosing Hodgkin's disease: A case report

Donald¹,

Green²,

White³

1980

Cancer

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The pathogenesis of Hodgkin's disease

Cited by 14 publications

References 67 publications

Clonal analysis of T lymphocytes in spleens from patients with Hodgkin's disease. Frequent occurrence of unusual T4‐positive cells which co‐express cytolytic activity and production of interleukin‐2

Clonal analysis of T lymphocytes in spleens from patients with Hodgkin's disease. Frequent occurrence of unusual T4‐positive cells which co‐express cytolytic activity and production of interleukin‐2

Lectin staining of carbohydrates of haemic cells. III. The cells of Hodgkin's disease and other lymphomas

Mycosis fungoides associated with nodular sclerosing Hodgkin's disease: A case report

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