The Pathogenesis of Lipoid Nephrosis

Elwyn, Herman

doi:10.1001/archinte.1926.00120270069005

Cited by 14 publications

(3 citation statements)

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“…It may contribute to organ injury via several mechanisms through a process termed lipotoxicity [1]. Renal lipidosis, or lipid deposit in kidney biopsies has been associated with nephrotic syndrome [2]. However, whether excess lipids are the cause, or the consequence of glomerular injuries is not well known.…”

Section: Introductionmentioning

confidence: 99%

"Post-Transplant with Glomerular Lipidosis: A Case Report and a Review of Literature"

Alshehabi

2023

BJSTR

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There is increasing evidence that lipid accumulation in cells and tissues, a process known as lipotoxicity, can lead to dysfunction in multiple organs. Lipid accumulation has also been observed in the kidneys, resulting in glomerular lipidosis. In this report, we highlight a case of a 50-year-old gentleman who developed post-transplant glomerular lipidosis, and accordingly, we explore the treatment options used in his case based on the available literature.

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Section: Introductionmentioning

confidence: 99%

"Post-Transplant with Glomerular Lipidosis: A Case Report and a Review of Literature"

Alshehabi

2023

BJSTR

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“…Renal lipidosis or lipid deposits on kidney biopsy has been associated with nephrotic syndrome 1 . Systemic disorders of abnormal lipid metabolism including some lysosomal storage disorders and Lecithin Cholesterol Acyltransferase (LCAT) deficiency 2 are known to cause lipid deposition and progressive proteinuric kidney disease.…”

Section: Introductionmentioning

confidence: 99%

Posttransplant proteinuria due to Apolipoprotein E2 deposition in a kidney allograft

Ramakrishnan

Fields

Zhang

et al. 2021

American Journal of Transplantation

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Renal lipidosis or lipid deposits on kidney biopsy has been associated with nephrotic syndrome. 1 Systemic disorders of abnormal lipid metabolism including some lysosomal storage disorders and Lecithin Cholesterol Acyltransferase (LCAT) deficiency 2 are known to cause lipid deposition and progressive proteinuric kidney disease. However, lipid deposition disorders that are limited to the kidney without systemic manifestations are rare. Lipoprotein Glomerulopathy (LPG) is one such extensively described disorder classically characterized by lipoprotein thrombi in glomeruli, proteinuria and progressive kidney disease due to abnormal variants of Apolipoprotein E (ApoE). 3,4 More commonly occurring ApoE variants such as homozygosity for ApoE2 have also been associated with kidney disease. 4,5 As these lipid disorders are rare and have varying presentations, their identification can often be missed,

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“…He remained in good health until Nov. 6,1925, when he was taken to the Milwaukee County Hospital because of cervical adenitis and generalized edema, most prominent about the face, as presented in the accompanying table. He remained in good health until Nov. 6,1925, when he was taken to the Milwaukee County Hospital because of cervical adenitis and generalized edema, most prominent about the face, as presented in the accompanying table.…”

mentioning

confidence: 99%

Chronic Glomerulonephritis With Lipoid Changes

Murphy¹

1930

Arch Intern Med (Chic)

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The Pathogenesis of Lipoid Nephrosis

Cited by 14 publications

References 14 publications

"Post-Transplant with Glomerular Lipidosis: A Case Report and a Review of Literature"

"Post-Transplant with Glomerular Lipidosis: A Case Report and a Review of Literature"

Posttransplant proteinuria due to Apolipoprotein E2 deposition in a kidney allograft

Chronic Glomerulonephritis With Lipoid Changes

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