The pathogenesis of steroid-induced osteonecrosis of the femoral head: A systematic review of the literature

Wang, Ao; Ren, Mingchun; Wang, Jincheng

doi:10.1016/j.gene.2018.05.091

Cited by 152 publications

(125 citation statements)

References 89 publications

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“…Apoptosis is a normal physiological process that plays a crucial role in the pathogenesis and progression of glucocorticoid-induced ONFH [24]. Not only osteoblasts but also BMECs participate in the apoptosis process during the progression of ONFH.…”

Section: Discussionmentioning

confidence: 99%

Decreased angiogenic and increased apoptotic activities of bone microvascular endothelial cells in patients with glucocorticoid-induced osteonecrosis of the femoral head

Liu

Zuo

et al. 2020

BMC Musculoskelet Disord

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Background: Glucocorticoid-induced osteonecrosis of the femoral head (ONFH) is closely associated with the dysfunction of the bone microvascular endothelial cells (BMECs). The present study investigated the angiogenic and apoptotic activity of the BMECs in glucocorticoid-induced ONFH. Methods: This study enrolled a total of 12 patients, six of whom were assigned to the ONFH group whereas the other six served as the control group. The ONFH group was composed of patients with glucocorticoid-induced ONFH while the control group had femoral neck fractures. BMECs were isolated from the subchondral region of the femoral head. Cell proliferation, cell viability, tube formation assay, Transwell assay, TUNEL assay, and Western blot analysis were performed.Results: BMECs of the two groups were successfully isolated and identified. No significant differences were noticed in BMECs proliferation between the two groups. However, compared to the control, cell viability, tube formation, and migration of BMECs were significantly decreased and the number of TUNEL positive cells was markedly increased in the ONFH group. In the ONFH group, it was also noted that the amount of Bax and cleaved-caspase3 was elevated while that of Bcl-2 was reduced. Conclusion:The findings of our study revealed that BMECs obtained from the glucocorticoid-induced ONFH patients had decreased angiogenic and increased apoptotic activities, which could explain the pathogenesis and progression of glucocorticoid-induced ONFH.

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Section: Discussionmentioning

confidence: 99%

Decreased angiogenic and increased apoptotic activities of bone microvascular endothelial cells in patients with glucocorticoid-induced osteonecrosis of the femoral head

Liu

Zuo

et al. 2020

BMC Musculoskelet Disord

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“…In recent years, GC‐induced ONFH has received much attention because of its high disability rate and the large number of patients on GC therapy. Although GC‐induced ONFH is believed to be related to disturbances in bone metabolism and lipid metabolism, inflammation and cell apoptosis, as well as local circulation and coagulation, its etiology has yet to be fully elucidated …”

mentioning

confidence: 57%

“…Although GC-induced ONFH is believed to be related to disturbances in bone metabolism and lipid metabolism, inflammation and cell apoptosis, as well as local circulation and coagulation, its etiology has yet to be fully elucidated. 5,6 GC-induced ONFH is diagnosed principally on the basis of the clinical manifestations, imaging features, and history of GC therapy. However, it can be asymptomatic in the early stages, and the typical imaging features are normally only found in the middle or late stages.…”

mentioning

confidence: 99%

Serum Biomarkers Related to Glucocorticoid‐Induced Osteonecrosis of the Femoral Head: A Prospective Nested Case‐Control Study

Wang

Hua

Chang

et al. 2019

Journal Orthopaedic Research

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Early diagnosis and prevention of glucocorticoid (GC)‐induced osteonecrosis of the femoral head (ONFH) continues to be a challenging problem for clinicians and researchers. However, the role of circulating biomarkers for GC‐induced ONFH, which may reveal individual susceptibility and facilitate earlier diagnosis, remains to be determined. The aim of this study was to identify potential biomarkers that may predict early GC‐induced ONFH. A total of 123 patients scheduled for initial systemic GC therapy were enrolled in this prospective nested case–control study. The serum concentrations of 13 potential biomarkers were measured in seven patients with GC‐induced ONFH, diagnosed instantly after short‐term use of GCs and in 20 controls who did not develop osteonecrosis despite similar GC therapy. Biomarkers were measured both before and after taking GCs to identify any differences in marker levels and the changes during GC therapy between two groups. Type I collagen cross‐linked C‐telopeptide (β‐CTX; p = 0.000) was significantly lower, high‐density lipoprotein cholesterol (p = 0.092) and apolipoprotein (apo)‐B/apo‐A1 (p = 0.085) tended to be lower and higher, respectively, before GC treatment in osteonecrosis group. After GC therapy, β‐CTX (p = 0.014) was significantly lower and amino terminal telopeptide of procollagen type I (PINP; p = 0.068) tended to be lower in the osteonecrosis group. As secondary outcomes, we observed remarkable changes in nine potential biomarkers following short‐term GC therapy in both groups. In conclusion, we found that β‐CTX, could potentially be used to predict GC‐induced ONFH before GC therapy. Lower β‐CTX and PINP are promising biomarkers for the early diagnosis of GC‐induced ONFH. These findings need to be confirmed in large‐scale prospective studies. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2348–2357, 2019

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“…MiRNAs play important roles in the regulation of transcription [13]. Increasing studies have investigated differentially expressed miRNAs related to SONFH, identifying hundreds of such miRNAs [14]. Relative RNA expression p = 0.010 p = 0.005 p = 0.004 p = 0.027 p = 0.001 p = 0.001 p = 0.008 p = 0.009 hsa_circ_0093677 hsa_circ_0003344 hsa_circ_0000069 hsa_circ_0004692 hsa_circ_0002737 hsa_circ_0097391 hsa_circ_0097391 hsa_circ_0140628…”

Section: Discussionmentioning

confidence: 99%

Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head

Zhu

et al. 2019

Disease Markers

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Background. A growing number of studies have suggested that circular RNAs (circRNAs) serve as potential diagnostic biomarkers in many diseases. However, the role of circRNAs in steroid-induced osteonecrosis of the femoral head (SONFH) has not been reported. Methods. Secondary sequencing was performed to profile circRNA expression in peripheral blood samples from three SONFH patients and three healthy individuals. We confirmed our preliminary findings by qRT-PCR. Bioinformatics analysis was conducted to predict their functions. Results. The result showed 345 dysregulated circRNAs. qRT-PCR of eight selected circRNAs preliminarily confirmed the results, which were consistent with RNA sequencing. Bioinformatics analyses were performed to predict the functions of circRNAs to target the genes of miRNAs and the networks of circRNA-miRNA-mRNA interactions. Conclusions. This study provides a new and fundamental circRNA profile of SONFH and a theoretical basis for further studies on the functions of circRNAs in SONFH.

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The pathogenesis of steroid-induced osteonecrosis of the femoral head: A systematic review of the literature

Cited by 152 publications

References 89 publications

Decreased angiogenic and increased apoptotic activities of bone microvascular endothelial cells in patients with glucocorticoid-induced osteonecrosis of the femoral head

Decreased angiogenic and increased apoptotic activities of bone microvascular endothelial cells in patients with glucocorticoid-induced osteonecrosis of the femoral head

Serum Biomarkers Related to Glucocorticoid‐Induced Osteonecrosis of the Femoral Head: A Prospective Nested Case‐Control Study

Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head

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