The pathogenesis of tendolipomatosis; an electron microscopical study

Józsa, László; Réffy, A; Bálint, J

doi:10.1007/bf00266836

Cited by 35 publications

(20 citation statements)

References 4 publications

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“…Jozsa et al demonstrated this as lipid deposits along collagen fibrils which were observed utilizing electron microscopy, possibly disrupting the structural integrity of the tendon and making it more prone to tendon rupture or injury. 60 …”

Section: Hypercholesterolemiamentioning

confidence: 99%

What is the Role of Systemic Conditions and Options for Manipulation of Bone Formation and Bone Resorption in Rotator Cuff Tendon Healing and Repair?

Lee

Gumucio

Mendias

et al. 2017

Techniques in Shoulder &Amp; Elbow Surgery

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Rotator cuff pathology is a significant cause of shoulder pain. Operative repair of rotator cuff is an established standard of care for these patient, however, failure of the procedure is common. Systemic conditions such as diabetes mellitus, hypocholesteremia, thyroid disease, and smoking significantly affect the outcomes of rotator cuff repair and have significant implications for the management of these patients. Diabetes mellitus has been proposed to damage tendons through non-enzymatic glycosylation of collagen with advanced glycation end product formation and impaired microcirculation. Hypocholesteremia may lead to fatty infiltration and subsequent pro-inflammatory degenerative enzymatic degeneration. Thyroid disease may disrupt tendon homeostasis through the alteration of collagen production and the accumulation of glycosaminoglycans. Lastly, smoking inhibits tendon healing through the induction of hypovascularity and hypoperfusion. Understanding of the implications these systemic conditions have on the outcomes is important in the management of rotator cuff disease.

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Section: Hypercholesterolemiamentioning

confidence: 99%

What is the Role of Systemic Conditions and Options for Manipulation of Bone Formation and Bone Resorption in Rotator Cuff Tendon Healing and Repair?

Lee

Gumucio

Mendias

et al. 2017

Techniques in Shoulder &Amp; Elbow Surgery

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“…The lipomatous tendon seems to be a combination of normal structures with variable areas of lipid cells. Around the lipocytes, a dense reticular network of thin, type I11 collagen fibers can be found (26). As the accumulation of lipid cells expands, they form chains and three-dimensional conglomerations (1,5).…”

Section: Tendolipomatosismentioning

confidence: 99%

Histopathological findings in spontaneous tendon ruptures

Józsa¹,

Kannus

1997

Scandinavian Med Sci Sports

151

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A spontaneous rupture of a tendon may be definied as a rupture that occurs during movement and activity, that should not and usually does not damage the involved musculotendinous units (1). Spontaneous tendon ruptures were uncommon before the 1950s. Böhler found only 25 Achilles tendon ruptures in Wien between 1925 and 1948 (2). Mösender & Klatnek treated 20 Achilles tendon ruptures between 1953 and 1956, but 105 ruptures between 1964 and 1967 (3). Lawrence et al. found only 31 Achilles tendon ruptures in Boston during a period of 55 years (1900‐1954) (4). During the recent decades tendon ruptures have, however, become relatively common in developed countries, especially in Europe and North America. A high incidence of tendon ruptures has been reported in Austria, Denmark, Finland, Germany, Hungary, Sweden, Switzerland and the USA; somewhat lower incidences have been reported in Canada, France, Great Britain and Spain. On the other hand, Greece, Japan, the Netherlands and Portugal have reported a clearly lower incidence. Interestingly, Achilles tendon ruptures are a rarity in developing countries, ecpecially in Africa and East‐Asia (5). In many developed countries, the increases in the rupture incidence have been dramatic. In the National Institute of Traumatology in Budapest, Hungary, the number of patients with an Achilles tendon rupture increased 285% in men and 500% in women between two successive 7‐year periods, 1972‐1978 and 1979–1985(5).

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“…These include dyslipidemia, hypertension, glucose intolerance, and insulin resistance (5,25,28). Because lipid deposition is known to occur in tendons (1,11), high cholesterol levels have been observed among individuals with Achilles tendon rupture (19,22), and the esterified fraction of cholesterol is elevated in biopsies from Achilles tendinopathy subjects (29) we chose to focus on serum lipid profiles.…”

mentioning

confidence: 99%

Dyslipidemia in Achilles Tendinopathy Is Characteristic of Insulin Resistance

Gaida

Alfredson

Kiss³

et al. 2009

Medicine &Amp; Science in Sports &Amp; Exercise

111

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This pattern of dyslipidemia is characteristic of the dyslipidemia displayed by individuals with insulin resistance and is common in the metabolic syndrome. Two additional aspects of tendinopathy research support a connection with the metabolic syndrome. First, tendinopathy has been associated with greater waist circumference, as has the metabolic syndrome. Second, insulin resistance has been associated with fat deposition in muscle (primarily intracellular), whereas fat deposition in tendon has been found among those with tendon pain.If tendinopathy is confirmed to be associated with dyslipidemia and the metabolic syndrome in larger studies, it may be appropriate to redefine our concept of tendinopathy to that of a cardiovascular disease (CVD). In this case, we may be able to draw considerably on CVD research to improve our understanding of tendinopathy, and perhaps treating CVD risk factors will improve the treatment of tendinopathy.

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The pathogenesis of tendolipomatosis; an electron microscopical study

Cited by 35 publications

References 4 publications

What is the Role of Systemic Conditions and Options for Manipulation of Bone Formation and Bone Resorption in Rotator Cuff Tendon Healing and Repair?

What is the Role of Systemic Conditions and Options for Manipulation of Bone Formation and Bone Resorption in Rotator Cuff Tendon Healing and Repair?

Histopathological findings in spontaneous tendon ruptures

Dyslipidemia in Achilles Tendinopathy Is Characteristic of Insulin Resistance

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