The pathogenesis of vacuoles produced in rat and mouse liver cells by a conjugate of adenine arabinoside monophosphate with lactosaminated albumin

Fiume, L.; Betts, Christine M.; Busi, C.; Corzani, S.; Derenzini, Massimo; Stefano, Giuseppina Di; Mattioli, A.

doi:10.1016/0168-8278(92)90062-t

Cited by 13 publications

(2 citation statements)

References 22 publications

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“…Two hours after i.v. injection of L‐[ 14 C]HSA (20 μg/g) the rats were killed under ether anesthesia and parenchymal and sinusoidal cells of liver were isolated by collagenase perfusion, according to Seglen (26), following the procedure described in detail in Fiume et al (27). Total radioactivity of cell preparations was counted and expressed as d.p.m/μg cell proteins/SA of L‐[ 14 C]HSA.…”

Section: Methodsmentioning

confidence: 99%

Enhanced uptake of lactosaminated human albumin by rat hepatocarcinomas: implications for an improved chemotherapy of primary liver tumors

Stefano

Fiume

Bolondi

et al. 2005

Liver International

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Section: Methodsmentioning

confidence: 99%

Enhanced uptake of lactosaminated human albumin by rat hepatocarcinomas: implications for an improved chemotherapy of primary liver tumors

Stefano

Fiume

Bolondi

et al. 2005

Liver International

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“…Chemical modification of plasma proteins like albumin can make them susceptible to uptake by scavenger receptors on cells other than the hepatocyte (10). Immunogenicity and the formation of hepatic vacuoles have also been reported with lactosylated albumin (11,12). Problems of protein carriers for drug delivery have been recently reviewed (13).…”

Section: Introductionmentioning

confidence: 99%

Arabinogalactan for Hepatic Drug Delivery

Groman¹,

Enriquez²,

Jung³

et al. 1994

Bioconjugate Chem.

112

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Arabinogalactan, a polysaccharide from the tree Larix occidentalis, has been purified and its biological and physical properties described. Intravenous injection of radiolabeled arabinogalactan (4 mg/kg) in rats resulted in 52.5% of the dose being present in the liver, while prior injection of asialofetuin (100 mg/kg) reduced hepatic radioactivity to 3.54%. Gel chromatography indicates arabinogalactan is a single species of 19 kDa, while light scattering gave a molecular weight of 40 kDa. Glycosyl linkage analysis of arabinogalactan is consistent with a highly branched structure comprising a backbone of 1,3-linked galactopyranose connected by 1,3-glycosidic linkages, comprised of 3,4,6-,3,6-, and 3,4- as well as 3-linked residues. In the carbon-13 NMR spectra, the major resonances of arabinogalactan are assigned to beta-galactopyranose, beta-arabinofuranose, and beta-arabinopyranose. Arabinogalactan produced no adverse reactions in single intravenous dose (mouse, 5000 mg/kg) and repeat dose toxicity studies (rats, 500 mg/kg/day, 90 days). When tritiated arabinogalactan was injected, radioactivity cleared from the liver with a half-life of 3.42 days. Arabinogalactan has properties that make it suitable as a carrier for delivering diagnostic or therapeutic agents to hepatocytes via the asialoglycoprotein receptor.

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Ultralstructural and biochemical studies of the effect of polychlorinated biphenyl on mouse parotid gland cells

Kawasaki

Mataki

Mizuno

1995

Archives of Oral Biology

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The pathogenesis of vacuoles produced in rat and mouse liver cells by a conjugate of adenine arabinoside monophosphate with lactosaminated albumin

Cited by 13 publications

References 22 publications

Enhanced uptake of lactosaminated human albumin by rat hepatocarcinomas: implications for an improved chemotherapy of primary liver tumors

Enhanced uptake of lactosaminated human albumin by rat hepatocarcinomas: implications for an improved chemotherapy of primary liver tumors

Arabinogalactan for Hepatic Drug Delivery

Ultralstructural and biochemical studies of the effect of polychlorinated biphenyl on mouse parotid gland cells

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