The Pathogenic Role of Actinomyces spp. and Related Organisms in Genitourinary Infections: Discoveries in the New, Modern Diagnostic Era

Gajdács, Márió; Urbán, Edit

doi:10.3390/antibiotics9080524

Cited by 29 publications

(23 citation statements)

References 150 publications

(302 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… 20 , 21 Other rare pathogenic microorganisms, such as anaerobes, Actinomyces and Actinomyces -like organisms (ALOs), had distributed in various ages of male genitourinary infection. 6 , 22 In our study, the proportion of patients under 35 years old was 18.2% (4 cases all had cUTIs), which was higher than expectation. This might suggest a trend to the demographic change in severe male genitourinary infection.…”

Section: Discussioncontrasting

confidence: 62%

An Investigation of the Male Genitourinary Abscess Originated from Urinary Tract in a Tertiary Hospital, Shanghai, China, from 2004 to 2019

Tan

Tian

Zhao

et al. 2021

IDR

View full text Add to dashboard Cite

Background: Male genitourinary abscess is one of the serious complications of urinary tract infections (UTIs). There were few researches on the clinical and pathogenic characteristics of male genitourinary abscess. Patients and Methods: A retrospective observational study was conducted between January 2004 and April 2019. Male patients with genitourinary abscess originated from urinary tract, including sites of scrotum, testis, epididymis, spermatic cord, and prostate, were enrolled. Clinical and microbial records were collected and analyzed, and antimicrobial susceptibility testings were performed according to CLSI standard. Whole-genome sequencing was applied to detect the β-lactamase genes and virulence genes, as well as to determine the multilocussequence typing (MLST) of the collected Klebsiella pneumoniae (K. pneumoniae) isolates. Results: A total of 22 male patients were included. The main clinical symptoms were fever (86.4%), scrotal swelling (68.2%), local skin warmth (59.1%) and ulceration (45.5%). Urinary irritation was often presented in prostate involved abscess. Ultrasound features had a 94.7% positive rate. Surgical treatment, including abscess drainage, was helpful to the prognosis. No matter where the specimens obtained from, including blood, urine or pus, multidrug-resistant K. pneumoniae was the dominant (11 cases, 50.0%) microorganism in positive cultures. Nine of eleven K. pneumoniae isolates had been preserved and recovered. As for MLST typing, all the nine available isolates of K. pneumoniae belonged to the ST11 type and characterized with bla KPC-2 carbapenemase gene. Virulence genes rmpA2, ybtS, kfuC, wzi, aerobactin genes (iucABCD and iutA) and type 3 fimbriae genes (mrkAD) were identified in all the K. pneumoniae isolates. Conclusion:It seemed that more patients under 35 years old were vulnerable to genitourinary abscess. There was an increasing trend that multidrug-resistant K. pneumoniae isolates with multiple virulence genes were involved in male genitourinary abscess. Prompt and proper antibiotic use, combined with adequate drainage of the abscess, was important to prognosis.

show abstract

Section: Discussioncontrasting

confidence: 62%

An Investigation of the Male Genitourinary Abscess Originated from Urinary Tract in a Tertiary Hospital, Shanghai, China, from 2004 to 2019

Tan

Tian

Zhao

et al. 2021

IDR

View full text Add to dashboard Cite

show abstract

“…Dysbiosis of the gut microbiome has also been associated with many cancers ( 8 , 14 – 16 ), including LC ( 8 ). A previous study suggested an increase in Enterococcus in the stool of LC patients compared to that of healthy subjects and a decrease in Bifidobacterium and Actinobacteria ( 6 ), of which others have shown that the response to immunotherapy in NSCLC patients is associated with specific changes of individual species, such as Alistipes putredinis , Bifidobacterium longum , and Prevotella copri as well as the overall diversity of the gut microbiome ( 7 , 8 ).…”

Section: Introductionmentioning

confidence: 99%

Alterations of the Human Lung and Gut Microbiomes in Non-Small Cell Lung Carcinomas and Distant Metastasis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The characteristic feature of infections caused by microorganisms of the order Actinomycetales is a chronic disease, granulomatous (nocardiosis and rhodococcosis) or pyogranulomatous (actinomycosis) process in a macroorganism leading to formation of abscesses and fibrosis in various organs and tissues (Gajdács & Urbán, 2020). Animals rarely recover without an appropriate therapy.…”

Section: Introductionmentioning

confidence: 99%

Etiological factors in triggering non-specific allergic reactions to tuberculin in cattle

Завгородний

Pozmogova

Kalashnyk

et al. 2021

Regul. Mech. Biosyst.

View full text Add to dashboard Cite

The article presents the results of allergic and bacteriological studies of cattle from a tuberculosis-free farm. The presence of cattle reacting to an allergen from atypical mycobacteria was established in three allergic simultaneous tests during 2019–2020. Based on the results obtained, the causative agent of tuberculosis and atypical mycobacteria were not isolated during the bacteriological examination of a biological material from animals slaughtered for diagnostic purposes (n = 17), as well as soil (n = 5) and straw (n = 3) samples. However, microorganisms of the genera Nocardia (n = 2), Rhodococcus (n = 10), and Actinomyces (n = 5) were isolated from the biomaterial according to the results of microscopy, culture and biochemical tests. These microorganisms were also isolated from the soil and straw samples. Short-term non-specific reactions in cattle to mycobacterial allergens were due to the persistence and circulation of the aforementioned microorganisms closely related to mycobacteria. It was determined that the genera Nocardia and Rhodococcus are sensitive to the 1.0%, 2.0%, 3.0% solutions of glutaraldehyde, formaldehyde and sodium hydroxide. Thus, it is necessary to take into account the epizootic situation as to the presence of nocardioform microorganisms in the herd during routine allergic studies, as well as in case of differentiation between specific reactions and paraallergic and pseudoallergic ones. It is necessary to carry out comprehensive systematic studies of livestock and feed quality assessment. For the purpose of disinfection, glutaraldehyde and formaldehyde at a concentration of 1.0% are effective in destroying microorganisms of the genera Nocardia and Rhodococcus with 3-hour exposure or more.

show abstract

The Pathogenic Role of Actinomyces spp. and Related Organisms in Genitourinary Infections: Discoveries in the New, Modern Diagnostic Era

Cited by 29 publications

References 150 publications

An Investigation of the Male Genitourinary Abscess Originated from Urinary Tract in a Tertiary Hospital, Shanghai, China, from 2004 to 2019

An Investigation of the Male Genitourinary Abscess Originated from Urinary Tract in a Tertiary Hospital, Shanghai, China, from 2004 to 2019

Alterations of the Human Lung and Gut Microbiomes in Non-Small Cell Lung Carcinomas and Distant Metastasis

Etiological factors in triggering non-specific allergic reactions to tuberculin in cattle

Contact Info

Product

Resources

About