The Pathological Mechanisms of Obesity-Related Glomerulopathy: A review article

Kasim, Ali A.; Ataimish, Ahmed H.

doi:10.31351/vol30iss1pp22-28

Cited by 1 publication

(4 citation statements)

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“…Results in white adipose tissue (WAT) demonstrate a significant up-regulation in UCP1 gene expression level from the fifth week after treating with simvastatin 9mg/kg/day treatment (Group II), and from fourth week of simvastatin at18mg/kg/day therapy (Group III). However, treating with omega-3 (1ml/day) (Group IV) results from increase UCP1 gene expression from third week of therapy, also in case of mixed dose of simvastatin and omega-3 (Group V) rats where UCP1 gene expression level from increased from third week of therapy (4) . To our knowledge no study was conducted to study the effect of simvastatin, omega 3 and its cotreatment.…”

Section: Discussionmentioning

confidence: 99%

“…GPR120 activation results in activation of thermogenic transcription factors in brown fat, namely, PRDM16, Pgc-1α, and PPARγ. This leads to increase expression of UCP 1 in brown adipose tissue with a consequence increase in energy expenditure and reduction in body weight (4,40) . This study gave a significant increase in UCP1 expression level in BAT from fifth week of simvastatin 9mg/kg/day treatment (Group II), while simvastatin treatment 18mg/kg/day (Group III) and omega-3 combined with simvastatin (9mg/kg/day) (Group V) gave significant increase in UCP1 expression from the first week of therapy, Moreover, treatment with omega-3 (Group IV) gave significant increase in UCP-1 expression from second week when compared to obese HFD (Group I) rats.…”

Section: Discussionmentioning

confidence: 99%

“…It is typically defined as an increased energy intake combined with less energy expenditure (2) . The change in life style from highly active, hard-working jobs to sedentary life results in imbalance in weight gain (3) and as a result obesity occurs; with increase in the risk of morbidity due to chronic diseases mainly type 2 diabetes and cardiovascular disease (4,5) , with increasing in mortality scales (6) . Adipose tissue has emerged as a dynamic organ and plays an important role in the pathogenesis of obesity and its associated metabolic disorders (4,7) .…”

Section: Introductionmentioning

confidence: 99%

“…The change in life style from highly active, hard-working jobs to sedentary life results in imbalance in weight gain (3) and as a result obesity occurs; with increase in the risk of morbidity due to chronic diseases mainly type 2 diabetes and cardiovascular disease (4,5) , with increasing in mortality scales (6) . Adipose tissue has emerged as a dynamic organ and plays an important role in the pathogenesis of obesity and its associated metabolic disorders (4,7) . It is classified into white adipose tissue (WAT) and brown adipose tissue (BAT), which are visibly distinguishable according to tissue color however they differ in shape, size, and the intracellular structure of their organelles (8) .…”

Section: Introductionmentioning

confidence: 99%

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Anti-obesity effect of simvastatin and omega-3 and its combination on obese model male Wistar rats

ALJuboury

Al-Shawi

2022

IJPS

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Strategies to reduce obesity have become main priority for many health institution and health staff around the world, as the prevalence of obesity has risen and exacerbated in most of the world mainly because of the modern life style which tend to be more sedentary with an increase eating unhealthy fast western food. Many years ago, the lipid-lowering drug simvastatin; and omega-3 were considered as a traditional lipid-lowering drug that have been well-documented to possess anti-inflammatory, cardioprotective and triglyceride-lowering properties; and their co-administration may demonstrate a complementary effect in lowering patients' triglycerides and total cholesterol to treat atherosclerosis. Many previous studies have been found other beneficial effects for simvastatin, and omega-3; since, simvastatin can be used for the treatment of Alzheimer's disease; and for prevention of prostate cancer; while omega 3 can reduce the risk of sudden cardiac death in addition to preventing obesity that has been documented by recent studies. But, the effect of simvastatin alone or its combination with omega-3 as potential anti-obesity therapy and /or protection against obesity is not yet known through their effects on thermogenic factors. Aim of the study is to evaluate the effect of simvastatin on thermogenic genes including (UCP1) using quantitative real time PCR, while the expression of uncoupling protein 1 (UCP1) protein was detected in iBAT and iWAT adipocyte by immunohistochemistry. Method One hundred twenty (120) male Wistar rats (five-six week age and weighing 100-150g) were allocated into five groups: treated with two different doses of simvastatin, omega-3 and mixed treatment, in addition to high fat diet group which considered as a control group. Treatments were given for eight weeks. Three rats from each group were weekly-authenticated along the 60 days interscapular brown adipose tissue (iBAT) and inguinal white adipose tissues (iWAT) were obtained. Results; showed that simvastatin and omega-3 have an obvious activation of UCP1genes, this reflects an increase in thermogenic process in adipose tissue in obese high fat diet rats and their combination exert a synergistic increase in the thermogenic mechanism when compared to simvastatin 9mg/ kg /day alone. Conclusion this study gives a hope for the utilization of simvastatin either alone or in combination with omega-3 as anti-obesity therapy; through their enhancement of thermogenic in white and brown adipose tissues with a consequent weight loss.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%