The Pathology of Bladder Neck Obstruction in the Female Patient

Corrin, B.; Mayor, D.; Moore, Thomas

doi:10.1016/s0022-5347(17)64431-8

Cited by 16 publications

(5 citation statements)

References 19 publications

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“…Occasional plasma cells were seen in 13 cases, eosinophils in two, and polymorphs in one case. However, in each instance the cellular infiltration was mild and barely significant in contrast to the findings of Corrin, Mayor, and Moore (1963) in cases of bladder-neck obstruction. No abnormality was present in the nerve supply.…”

Section: Histological Findingscontrasting

confidence: 61%

Histological findings in pseudomembranous trigonitis

Henry¹,

Fox²

1971

J Clin Pathol

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SYNOPSIS Pseudomembranous trigonitis presents in females with the urethral syndrome and a characteristic lesion restricted to the trigone of the bladder. The histology shows 'vaginal metaplasia' of the epithelium together with underlying oedema and vascular dilatation, but no significant inflammation. Thirty-one such cases are included in the study. The possible role of oestrogen stimulation is discussed, together with a suggestion that the trigone has an embryological derivation distinct from the remainder of the bladder, allowing the trigonal epithelium to respond to oestrogenic stimulation in a manner denied to the vesical transitional epithelium.The 'urethral syndrome' is one of the causes of urgency and frequency of micturition in the female, which may be distressing at times. While this may be due to a number of factors, a certain proportion of these women have a normal urine, which is sterile on culture, and a characteristic lesion of the trigone on cystoscopy. Biopsy reveals a metaplasia of the trigonal epithelium which comes to resemble that of the vagina. This condition was first described by Heymann (1905) as 'trigonal cystitis' and has since passed under a variety of names, including pseudomembranous trigonitis, urethrotrigonitis, granular trigonitis, and vaginal or squamous metaplasia of the trigonal epithelium. In a survey of this condition endoscopic biopsy has been performed in 31 cases and the histological findings are described here. Three male patients are also included, two with a papillary transitional-cell carcinoma of bladder and one on oestrogen therapy for carcinoma of the prostate. Clinical FindingsThe 31 patients were all women with urgency and frequency of micturition. Their ages ranged from 15 to 73 with a mean of 38 years. Nine patients were postmenopausal. The urine was normal on routine testing and sterile on culture. Clinical examination was negative. Cystoscopic FindingsOn endoscopy, the changes are confined to the

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Section: Histological Findingscontrasting

confidence: 61%

Histological findings in pseudomembranous trigonitis

Henry¹,

Fox²

1971

J Clin Pathol

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“…Tue histological changes of resected tissue have been previously described (Moore, 1953(Moore, , 1961Corrin et al, 1963). Although squamous metaplasia, oedema and inflammatory cell infiltration are the common findings, in some cases appearences very similar to prostatic hyperplasia in the male have been reported (Moore, 1961 ).…”

Section: Pathologymentioning

confidence: 83%

“…Previously the author has stressed the presence of a female prostate, the homologue of the male prostate, quoting the literature on the clinical and embryological aspects (Moore, 1953(Moore, , 1960(Moore, , 1961Corrin et al, 1963).…”

Section: The Female Prostatementioning

confidence: 99%

The Female Prostate Updated

Moore¹

1975

Eur Urol

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“…The difficulty in establishing a diagnosis becomes frustrating for the patient and compounds the psychological impact of the condition. Early investigators had described abnormalities of bladder neck and sphincter function as a cause of urinary retention in neurologically normal adult women . However, before the description of FS in 1985, chronic urinary retention in young women was often attributed to psychological disturbance .…”

Section: Discussionmentioning

confidence: 99%

External urethral sphincter electromyography in asymptomatic women and the influence of the menstrual cycle

et al. 2015

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CRDs and DB activity in the external striated urethral sphincter is present in a high proportion of asymptomatic young women. This abnormal EMG activity has been shown for the first time to change during the menstrual cycle in individual women. CRDs and DBs are more commonly found in the luteal phase of the menstrual cycle. The importance of CRDs and DBs in the aetiology of urinary retention in young women remains uncertain. The distribution and or quantity of abnormal EMG activity in the external urethral sphincter may be important. In a woman with urinary retention the finding of CRDs and DBs by needle EMG does not automatically establish Fowler's syndrome as the explanation for the bladder dysfunction. Urethral pressure profilometry may be helpful in establishing a diagnosis. Opiate use and psychological stress should be considered in young women with urinary retention.

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The Pathology of Bladder Neck Obstruction in the Female Patient

Cited by 16 publications

References 19 publications

Histological findings in pseudomembranous trigonitis

Histological findings in pseudomembranous trigonitis

The Female Prostate Updated

External urethral sphincter electromyography in asymptomatic women and the influence of the menstrual cycle

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