The pathology of myocardial infarction in the pre- and post-interventional era

Pasotti, Michele; Prati, Francesco; Arbustini, Eloisa

doi:10.1136/hrt.2005.086934

Cited by 67 publications

(38 citation statements)

References 37 publications

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“…There is a peculiar region, defined as the hibernating myocardiun the human heart displaying vacuolated or empty cells, but the nuclei remain intact, consisting of non-contractile myocytes to adapt to chronic ischemia2627282930. Unlike infarcted myocardium, the cells in the hibernating myocardium remain viable even after losing myofibers and recover their functionality when reperfusion occurs.…”

Section: Resultsmentioning

confidence: 99%

Identification of cardiac progenitors that survive in the ischemic human heart after ventricular myocyte death

Omatsu‐Kanbe

Nozuchi

Nishino

et al. 2017

Sci Rep

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Atypically-shaped cardiomyocytes (ACMs) are beating heart cells identified in the cultures of cardiomyocyte-removed fractions obtained from adult mouse hearts. Since ACMs spontaneously develop into beating cells in the absence of hormones or chemicals, these cells are likely to be a type of cardiac progenitors rather than stem cells. “Native ACMs” are found as small interstitial cells among ventricular myocytes that co-express cellular prion protein (PrP) and cardiac troponin T (cTnT) in mouse and human heart tissues. However, the endogenous behavior of human ACMs is unclear. In the present study, we demonstrate that PrP+ cTnT+ cells are present in the human heart tissue with myocardial infarction (MI). These cells were mainly found in the border of necrotic cardiomyocytes caused by infarcts and also in the hibernating myocardium subjected to the chronic ischemia. The ratio of PrP+ cTnT+ cells to the total cells observed in the normal heart tissue section of mouse and human was estimated to range from 0.3–0.8%. Notably, living human PrP+ cTnT+ cells were identified in the cultures obtained at pathological autopsy despite exposure to lethal ischemic conditions for hours after death. These findings suggest that ACMs could survive in the ischemic human heart and develop into a sub-population of cardiac myocytes.

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Section: Resultsmentioning

confidence: 99%

Identification of cardiac progenitors that survive in the ischemic human heart after ventricular myocyte death

Omatsu‐Kanbe

Nozuchi

Nishino

et al. 2017

Sci Rep

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“…Rupture is most frequent when the infarct area is located in the ventricular free wall (1) and nearly always results in sudden death from massive blood loss into the pericardium, causing cardiac tamponade (1,6). Most infarct ruptures occur within the first week of MI (4,6), usually after transmural, first, or anterior MI, and in the setting of poor collateral circulation (7,8). Little is known about the molecular mechanisms of infarct rupture.…”

Section: Discussionmentioning

confidence: 99%

Defective Intercellular Adhesion Complex in Myocardium Predisposes to Infarct Rupture in Humans

Borne

Narula

Voncken

et al. 2008

Journal of the American College of Cardiology

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“…In subjects with obstructive atherosclerosis, pathological inspection of the myocardium and coronaries can usually clearly identify coronary disease and myocardial infarctions [22, 23]. A notable exception occurs when early myocardial infarction results in sudden cardiac death leaving only evidence of intracoronary thrombi [24].…”

Section: Resultsmentioning

confidence: 99%

Comprehensive Histological and Immunochemical Forensic Studies in Deaths Occurring in Custody

Nugent

Orellana-Barrios²,

Buscemi

2017

International Scholarly Research Notices

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In-custody deaths have several causes, and these include homicide, suicide, natural death from chronic diseases, and unexplained death possibly related to acute stress, asphyxia, excited delirium, and drug intoxication. In some instances, these deaths are attributed to undefined accidents and natural causes even though there is no obvious natural cause apparent after investigation. Understanding these deaths requires a comprehensive investigation, including documentation of circumstances surrounding the death, review of past medical history, drug and toxicology screens, and a forensic autopsy. These autopsies may not always clearly explain the death and reveal only nonspecific terminal events, such as pulmonary edema or cerebral edema. There are useful histologic and biochemical signatures which identify asphyxia, stress cardiomyopathy, and excited delirium. Identifying these causes of death requires semiquantitative morphologic and biochemical studies. We have reviewed recent Bureau of Justice Statistics on in-custody death, case series, and morphological and biochemical studies relevant to asphyxia, stress cardiomyopathy, and excited delirium and have summarized this information. We suggest that regional centers should manage the investigation of these deaths to provide more comprehensive studies and to enhance the expertise of forensic pathologists who would routinely manage potentially complex and difficult cases.

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The pathology of myocardial infarction in the pre- and post-interventional era

Cited by 67 publications

References 37 publications

Identification of cardiac progenitors that survive in the ischemic human heart after ventricular myocyte death

Identification of cardiac progenitors that survive in the ischemic human heart after ventricular myocyte death

Defective Intercellular Adhesion Complex in Myocardium Predisposes to Infarct Rupture in Humans

Comprehensive Histological and Immunochemical Forensic Studies in Deaths Occurring in Custody

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