The pathology of pulmonary sarcoidosis: update

Ma, Yanling; Gal, Anthony A.; Koss, Michael N.

doi:10.1053/j.semdp.2007.06.002

Cited by 131 publications

(96 citation statements)

References 82 publications

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“…Moreover, the vasculitis of Wegener's granulomatosis is more necrotizing and often suppurative. 18,19,27 A differential diagnosis with infection is more difficult: conventional microbiological analysis and use of overall tissue ancillary techniques such as special stains, immunohistochemistry, and molecular analysis (the latter for mycobacterial detection) are important. Above all, the use of a highly specific and sensitive molecular technique such as nested polymerase chain reaction for mycobacterial detection is mandatory.…”

Section: Discussionmentioning

confidence: 99%

Necrotizing Sarcoid Granulomatosis With an Uncommon Manifestation: Clinicopathological Features and Review of Literature

et al. 2013

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We report a rare case of an incidental diagnosis of necrotizing sarcoid granulomatosis (NSG) in a 60-y-old non-smoking male. The patient was admitted to the hospital for sudden back pain. Chest x-ray revealed areas of parenchymal consolidation and high-resolution computed tomography demonstrated a pulmonary nodular pattern with no lymph node enlargement. All laboratory and pulmonary function tests were normal. Bronchoscopy with bronchoalveolar lavage showed no sign of infection or specific inflammation. The diagnosis of NSG was made by histopathological examination of a surgical lung biopsy and by excluding other causes of granulomatous disease. In paucisymptomatic/asymptomatic patients, as in our case, therapy is not necessary, with a good prognosis and complete recovery. NSG is a rare systemic disease similar to sarcoidosis and Wegener's granulomatosis with a benign clinical course and should always be considered for patients with nodular pulmonary lesions even with subclinical or uncommon features.

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Section: Discussionmentioning

confidence: 99%

Necrotizing Sarcoid Granulomatosis With an Uncommon Manifestation: Clinicopathological Features and Review of Literature

et al. 2013

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“…Ruling out other causes of granulomatous disease (especially tuberculosis) is of paramount importance. (6) Biopsies should be performed at the most easily accessible sites, such as the skin or superficial lymph nodes. In some cases, fiberoptic bronchoscopy with bronchial and transbronchial biopsies is required, and, as a last resort, mediastinoscopy or surgical lung biopsy can be performed.…”

Section: Sarcoidosismentioning

confidence: 99%

Padrões tomográficos das doenças intersticiais pulmonares difusas com correlação clínica e patológica

et al. 2008

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High-resolution computed tomography (HRCT) is the radiological imaging technique best suited to revealing changes in lung structure. Various HRCT findings, taken together, can represent typical patterns. These patterns, in conjunction with the anatomical distribution of findings and with clinical data, can narrow the differential diagnosis of diffuse interstitial lung disease and, in many cases, indicate the correct diagnosis with a high degree of accuracy. The most common HRCT patterns seen in cases of diffuse interstitial lung diseases are the nodular pattern, linear/reticular opacities, cystic lesions, ground-glass opacities and consolidations. This article reviews the correlations between HRCT patterns and pathologic findings, summarizing the most common causes, as well as detailing the methods of investigation employed in order to diagnose the most common types of chronic diffuse lung disease.Keywords: Lung diseases, interstitial/pathology; Tomography, X-Ray computed; Diagnostic techniques, respiratory system. ResumoA tomografia de alta resolução (TCAR) é a técnica de imagem radiológica que reflete mais de perto as alterações da estrutura pulmonar. Os vários achados tomográficos podem ser combinados para formar padrões típicos. Estes, conjuntamente com a distribuição anatômica dos achados, e com os dados clínicos, podem estreitar o diagnóstico das doenças intersticiais pulmonares difusas, e em vários casos sugerir o diagnóstico correto com alto grau de acurácia. Os padrões mais comuns das doenças intersticiais pulmonares difusas na TCAR são o nodular, linear e reticular, lesões císticas, opacidades em vidro fosco e consolidações. Este artigo revisa as correlações entre os padrões tomográficos na TCAR e os achados patológicos e resume as causas mais comuns e os métodos de investigação para se atingir um diagnóstico nas doenças pulmonares crônicas difusas mais comuns.Descritores: Doenças pulmonares intersticiais/patologia; Tomografia computadorizada por raios X; Técnicas de diagnóstico do sistema respiratório.* Study carried out in the

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“…Although the aetiology of sarcoidosis remains uncertain [17], extensively conducted research has revealed several of the histopathologic and immunopathogenic events which occur during the development of noncaseating granulomas and might interpret the aforementioned redox imbalance [18,19].…”

Section: Discussionmentioning

confidence: 99%

Systemic oxidative stress in patients with pulmonary sarcoidosis

Koutsokera

Papaioannou

Malli

et al. 2009

Pulmonary Pharmacology & Therapeutics

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Background: A local redox imbalance has been reported in pulmonary sarcoidosis.However, so far no study has described a systemic redox imbalance in this context.The aim of the present study was to evaluate the systemic oxidative stress in patients with sarcoidosis and determine its relationship to treatment and indices of disease severity.Methods: 35 patients with histologically proven pulmonary sarcoidosis and 13 healthy volunteers were included in the study. All patients were studied during a stable phase of their disease. Systemic oxidative stress was quantified in serum with the use of a commercially available spectrophotometric method (D-ROM test) which determines overall oxidative stress, by measuring total hydroperoxides. Oxidative stress was expressed in conventional units, i.e. Carratelli Units (UCarr), where 1UCarr corresponds to 0.8mg/L H 2 O 2 .Results: Serum oxidative stress levels were significantly higher in patients with sarcoidosis compared to those of normal subjects (390±25 vs 300±18) UCarr respectively, p=0.04). Patients not receiving systemic corticosteroids had higher levels of oxidative stress compared to steroid-treated patients (461.5±38 vs 315±20, p<0.01) and compared to controls (461.5±38 vs 300±18 UCarr, p<0.01). Oxidative stress did not correlate with diffusion lung capacity (DLCO), partial arterial oxygen tension (PaO 2 ), MRC dyspnoea scale or chest X-ray stage. Conclusions:Systemic oxidative stress is increased in patients with stable pulmonary sarcoidosis who do not receive systemic corticosteroids. This finding suggests a sustained oxidative burden even when clinical, functional and radiological criteria indicate disease stability.

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The pathology of pulmonary sarcoidosis: update

Cited by 131 publications

References 82 publications

Necrotizing Sarcoid Granulomatosis With an Uncommon Manifestation: Clinicopathological Features and Review of Literature

Necrotizing Sarcoid Granulomatosis With an Uncommon Manifestation: Clinicopathological Features and Review of Literature

Padrões tomográficos das doenças intersticiais pulmonares difusas com correlação clínica e patológica

Systemic oxidative stress in patients with pulmonary sarcoidosis

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