The pathophysiology of acquired premature ejaculation

Abstract

The second Ad Hoc International Society for Sexual Medicine (ISSM) Committee for the Definition of Premature Ejaculation defined acquired premature ejaculation (PE) as a male sexual dysfunction characterized by a the development of a clinically significant and bothersome reduction in ejaculation latency time in men with previous normal ejaculatory experiences, often to about 3 minutes or less, the inability to delay ejaculation on all or nearly all vaginal penetrations, and the presence of negative personal consequences, such as distress, bother, frustration and/or the avoidance of sexual intimacy. The literature contains a diverse range of biological and psychological etiological theories. Acquired PE is commonly due to sexual performance anxiety, psychological or relationship problems, erectile dysfunction (ED), and occasionally prostatitis and hyperthyroidism, consistent with the predominant organic etiology of acquired PE, men with this complaint are usually older, have a higher mean BMI and a greater incidence of comorbid disease including hypertension, sexual desire disorder, diabetes mellitus, chronic prostatitis, and ED compared to lifelong, variable and subjective PE.

Silodosin versus naftopidil in the treatment of premature ejaculation: A prospective multicenter trial

“…In addition, 42% of patients that had ED that were managed by PDE5‐Is before enrollment to the study. These facts showed that patients who seek treatment for PE are varied and do not necessarily have life‐long PE, and frequently have PE combined with ED . At the present point in Japan, PE is not been well recognized as a medical condition that is treatable.…”

“…At the present point in Japan, PE is not been well recognized as a medical condition that is treatable. Subsequently, only limited patients were able to be enrolled in the present study, although the latent population who suffer from PE seems to be significant . It is necessary to increase the knowledge of PE as a common sexual condition as well as ED.…”

“…These facts showed that patients who seek treatment for PE are varied and do not necessarily have life-long PE, and frequently have PE combined with ED. 2,5 At the present point in Japan, PE is not been well recognized as a medical condition that is treatable. Subsequently, only limited patients were able to be enrolled in the present study, although the latent population who suffer from PE seems to be significant.…”

“…PE is a common sexual problem that significantly impacts QOL of patients and their partners through lower satisfaction with sexual intercourse and negative personal consequences . This significant problem affects not only young men, but also middle‐aged and older men with other QOL diseases, such as LUTS and ED . Thus treatment of PE restored the QOL of men and their partners in a wide range of age groups.…”

“…1 This significant problem affects not only young men, but also middle-aged and older men with other QOL diseases, such as LUTS and ED. [1][2][3][4][5] Thus treatment of PE restored the QOL of men and their partners in a wide range of age groups.…”