The pathophysiology of otosclerosis: Review of current research

Rudić, Milan; Keogh, Ivan; Wagner, Richard; Wilkinson, Eric P.; Kiros, Nega; Ferrary, Évelyne; Sterkers, Olivier; Grayeli, Alexis Bozorg; Žarković, Kamelija; Žarković, Neven

doi:10.1016/j.heares.2015.07.014

Cited by 95 publications

(78 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Stapes fixation or deformity is one of the main causes of middle-ear conductive hearing loss (MECHL), wherein otosclerosis accounts for the highest proportion of cases [1] . Otosclerosis is characterized by the spongization of the inner ear capsula ossium and re-ossification that causes ear-bone fixation, resulting in progressive conductive hearing loss and deafness [2] .…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Laser and Non-Laser Stapes Surgeries

Gao²,

Tang³

et al. 2017

Int Adv Otol

View full text Add to dashboard Cite

OBJECTIVE:This study aimed to observe differences in the efficacy of laser and surgical treatments of middle-ear conductive hearing loss (MECHL). MATERIALS and METHODS:A total of 276 ears of 267 patients with MECHL were divided into laser (n=172) and surgical (n=104) treatment groups according to the treatment method. Changes in the air-bone gap (ABG) after treatment and at the time of final follow-up were compared. An ABG value <20 dB was defined as effective and an ABG value <10 dB, significantly effective. The long-term treatment effects were also compared at the time of final follow-up. Additionally, postoperative adverse reactions were recorded for both the groups. RESULTS:The mean follow-up period was 76.77±43.62 months (range: 12-168 months). No significant difference in ABG was found between the two groups (21.31±11.64 dB vs. 19.14±9.79 dB, p>0.05). However, the laser treatment group showed slightly better results than the surgical treatment group at the final follow-up, although the difference between the groups was not found to be significant (11.69±9.98 dB vs. 12.62±10.94 dB, p>0.05). There was no difference in the long-term treatment effects between the two groups (effective: 87.21% vs. 88.46%, p>0.05; significantly effective: 55.81% vs. 56.73%, p>0.05). The incidence rates of postoperative adverse reactions were not significantly different. CONCLUSION:The treatment efficacy of laser and surgical treatments for MECHL are similar.

show abstract

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Laser and Non-Laser Stapes Surgeries

Gao²,

Tang³

et al. 2017

Int Adv Otol

View full text Add to dashboard Cite

show abstract

“…1 Fissula ante fenestram located just before the oval window is the most common site involved with the otosclerotic foci. 2 Other popular localizing regions have also been discovered, such as on the stapes footplate, at the round window, pericochlear region, and the internal auditory canal.…”

Section: Introductionmentioning

confidence: 99%

A Case of Otosclerosis Treated with One Shot Laser-Assisted Stapes Surgery

et al. 2015

View full text Add to dashboard Cite

Otosclerosis is an abnormal bone growth that causes fixation of stapes, leading to hearing loss. Several stapes surgery techniques were introduced, including stapedotomy, partial and total stapedectomy according to the extent of removal of the foot plate. Application of lasers during a stapes surgery minimizes the risk of mechanical force into the inner ear, compared to that of the conventional micro-drill or micro-pick using stapes surgery. The ideal laser technique in stapedotomy should prevent thermal damage into the perilymph. Recently, one shot laser stapedotomy technique has been reported to minimize inner ear damage compared with the multiple shot technique. We experienced one shot laser stapedotomy including resection of stapedius tendon, posterior crusectomy, and stapedotomy as selection of different power, focus size and achieved satisfactory results without complications. Key words

show abstract

“…Adicionalmente, pode estar associada ao gene COL1A1 e, com isso, apresentar uma possível deficiência na síntese do colágeno tipo I, assim como a doença ser desencadeada em consequência a reações autoimunes contra o gene COL2A1 do colágeno tipo II (KAROSI; SKIKLAI, 2010; SCHRAUWEN; VAN CAMP, 2010;SILVEIRA, 2011;BITTERMANN et al, 2014;RUDIC et al, 2015 VAN CAMP, 2010;SILVEIRA, 2011;RUDIC et al, 2015). Um importante gene envolvido na patogênese de várias doenças inflamatórias é o fator de crescimento transformador β1 (Transforming Growth Factor -TGF-β1), o qual mostrou-se também em alguns casos de Otosclerose (KAROSI; SKIKLAI, 2010; SCHRAUWEN; VAN CAMP, 2010;RUDIC et al, 2015).…”

Section: Análise Dos Dadosunclassified

“…Um importante gene envolvido na patogênese de várias doenças inflamatórias é o fator de crescimento transformador β1 (Transforming Growth Factor -TGF-β1), o qual mostrou-se também em alguns casos de Otosclerose (KAROSI; SKIKLAI, 2010; SCHRAUWEN; VAN CAMP, 2010;RUDIC et al, 2015).…”

Section: Análise Dos Dadosunclassified

“…A prevalência maior da doença em mulheres é provável que seja em virtude de alteração no sistema endócrino uma vez que o aumento do nível de estrógeno e progesterona, bem como um desequilíbrio no sistema estrógeno-progesteronaprolactina podem contribuir para o desenvolvimento e a progressão da Otosclerose (KAROSI; SKIKLAI, 2010;SILVEIRA, 2011;RUDIC et al, 2015 (DIRKS, 1989;SILVEIRA, 2011;WEGNER et al, 2013). Após a realização de uma cirurgia bem-sucedida, ocorre a melhora de tais limiares tendo em vista a mudanças mecânicas do sistema tímpano-ossicular e não a modificações cocleares (HUEB; SILVEIRA, 2011).…”

The pathophysiology of otosclerosis: Review of current research

Cited by 95 publications

References 58 publications

Comparative Analysis of Laser and Non-Laser Stapes Surgeries

Comparative Analysis of Laser and Non-Laser Stapes Surgeries

A Case of Otosclerosis Treated with One Shot Laser-Assisted Stapes Surgery

Medidas de imitância acústica de banda larga em indivíduos com otosclerose

Contact Info

Product

Resources

About