The Pattern-Elicited Electroretinogram

Ringens, Peter J.; Vijfvinkel-Bruinenga, S.; Lith, G. H. M. Van

doi:10.1159/000309635

Cited by 25 publications

(1 citation statement)

References 7 publications

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“…[ 8 ] In contrast, there are reports of delayed latency in patients with glaucoma. [ 9 10 11 ] In the current study, using 1° pattern size and 3 and 8 Hz alternating pattern for PERG and ssPERG, respectively, we found a significant delay in the PERG P50 and N95 latencies and the ssPERG latency. However, there was no significant change in the PERG N35 wave latency.…”

Section: Discussionsupporting

confidence: 49%

Comparison of structural and functional tests in primary open angle glaucoma

Karaca

Dagli

Özge³

et al. 2020

Indian J Ophthalmol

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Purpose: To comparatively analyze the structural and functional tests used in the diagnosis and follow-up of glaucoma. Methods: Eighty eyes of 40 patients with primary open angle glaucoma (POAG) and 46 eyes of 23 healthy individuals were included in the study. Transient pattern electroretinography (PERG), steady-state PERG (ssPERG), computerized visual field (VF) screening, and examination of retinal nerve fiber layer (RNFL) and macular thickness on optical coherence tomography (OCT) were undertaken. The results were compared between the groups. Results: 80 eyes belonging to 40 patients with a diagnosis of POAG (23 female, 17 male) (18 mild 22 moderate POAG) with a mean of 57.37 (±8.6) years, and 46 eyes of 23 healthy individuals (14 female, 9 male) with a mean age of 55.30 (±8.09) years were included in the study. PERG P50 and N95 and ssPERG latency revealed a significant delay in the POAG group. When the wave amplitudes were examined, they were found to be significantly lower in both PERG and sSPERG tests for the POAG group, but the results were more pronounced in ssPERG. The latency values of PERG and ssPERG tests were not significantly correlated with any of the parameters of the remaining tests. However, the amplitude values of these tests had a positive correlation with the mean deviation value and negative correlation with the pattern standard deviation value of VF. All associated parameters were significant for the amplitude value of the ssPERG test. Conclusion: For the proper management of glaucoma, rather than approaching damage simply as the loss of retinal ganglion cells or the neuroretinal rim, it is necessary to focus on the ongoing anatomical and functional relationship and evaluate structural and functional tests together. In addition, ssPERG test, which is not widely adopted in routine practice, provides valuable information and is significantly correlated with OCT parameters.

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Section: Discussionsupporting

confidence: 49%

Comparison of structural and functional tests in primary open angle glaucoma

Karaca

Dagli

Özge³

et al. 2020

Indian J Ophthalmol

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The Pattern Visual Evoked Potential and Pattern Electroretinogram in Drusen-Associated Optic Neuropathy

Scholl

Song²,

Winkler³

et al. 1992

Arch Ophthalmol

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Abnormal pattern electroretinogram in Alzheimer's disease: Evidence for retinal ganglion cell degeneration?

Katz

Rimmer

Iragui

et al. 1989

Annals of Neurology

173

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We recorded pattern-reversal electroretinograms, flash electroretinograms, pattern-reversal visual evoked potentials, and flash visual evoked potentials in 6 patients with clinically diagnosed Alzheimer's disease and 6 age- and sex-matched control subjects. The mean amplitude of the pattern-reversal electroretinogram in the Alzheimer patients was significantly less than that of the control group (p = 0.004). This anomaly of the pattern-reversal electroretinogram may be a reflection of documented axonal depletion within the optic nerve and the degeneration of retinal ganglion cells seen in Alzheimer's disease. We found Alzheimer patients to have normal pattern-reversal visual evoked potentials and flash electroretinograms, but a delayed second positive component of the flash visual evoked potential. This combination of findings may be of diagnostic import in Alzheimer's disease.

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The Pattern-Elicited Electroretinogram

Cited by 25 publications

References 7 publications

Comparison of structural and functional tests in primary open angle glaucoma

Comparison of structural and functional tests in primary open angle glaucoma

The Pattern Visual Evoked Potential and Pattern Electroretinogram in Drusen-Associated Optic Neuropathy

Abnormal pattern electroretinogram in Alzheimer's disease: Evidence for retinal ganglion cell degeneration?

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