The Pattern of Alcohol Use in Alcohol-Related Cirrhosis in Indian Patients: AUDIT Indian Liver Study

Sharma, Mithun; Góra, B; Kulkarni, Anand V.; TR, Soumya; Shaik, Sameer; Jagtap, Nitin; Alla, Manasa; Gupta, Rajesh; Archana, Chintam; Qadri, Sabreena; Talukdar, Rupjyoti; Rao, Padaki Nagaraja; Reddy, Duvur Nageshwar

doi:10.1016/j.jceh.2022.12.009

Cited by 4 publications

(1 citation statement)

References 46 publications

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“…purchased from Sanofi Aventis Company. Rats in the untreated group received injections through their peritoneum of the same volume of saline (Sharma et al, 2023).…”

Section: Furosemide Dosementioning

confidence: 99%

Biochemical and Molecular Study of Lactuca sativa on Diuresis- induced experimentally in Rats.

Awadein,

Ali,

Muhammed Mahfouz

et al. 2024

Benha Veterinary Medical Journal

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This study investigated the biochemical and molecular effects of Lactuca sativa (lettuce) on diuresis induced experimentally in rats using furosemide. Diuresis, characterized by excessive urine production, is associated with various factors such as diet, diuretics, diabetes, and temperature. There were four groups of forty male rats (10 in each). Group I, or the normal control group, was given no medication. Group II, or the L. sativa group, rats received 2 Ml of a suspension of 150 mg/kg b.w of spray dried powder of L. sativa orally daily for 30 days. Group III (the furosemide group), rats received I/P injections of 0.4 ml of a dose of 40 mg/kg b.w./ of furosemide once daily for 30 days in order to induce diuresis. Group IV(L.sativa treated group) rats received 2 ml of a suspension of 150 mg/kg b.w of spray dried powder of L. sativa orally daily for 30 days Plus I/P injections of 0.4 Ml of a dose of 40 mg/kg b.w./ of furosemide once daily for 30 days. Results showed that furosemide induced significant changes in serum electrolyte levels, kidney function tests, and hormonal levels. However, L. sativa treatment in diuretic rats demonstrated a mitigating effect, normalizing several parameters. The gene expression of angiotensin-converting enzyme and Renin was downregulated in the L. sativa-treated group. In conclusion, L. sativa exhibited potential benefits in maintaining electrolyte balance and kidney function in diuretic-induced rats. These findings suggest a potential therapeutic role for L. sativa in conditions involving electrolyte imbalances and renal dysfunction, warranting further investigation, including clinical studies in human subjects.

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“…purchased from Sanofi Aventis Company. Rats in the untreated group received injections through their peritoneum of the same volume of saline (Sharma et al, 2023).…”

Section: Furosemide Dosementioning

confidence: 99%

Biochemical and Molecular Study of Lactuca sativa on Diuresis- induced experimentally in Rats.

Awadein,

Ali,

Muhammed Mahfouz

et al. 2024

Benha Veterinary Medical Journal

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Understanding Substance Use Disorder and Comorbidities: Insights from South Asia

Bhad,

Shukla

2024

Current Perspectives on Substance Use Disorders in South Asia

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Healthcare utilization and outcomes of living donor liver transplantation for patients with APASL-defined acute-on-chronic liver failure

Kulkarni,

Reddy,

Sharma

et al. 2023

Hepatol Int

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Background Liver transplantation (LT) is associated with excellent survival in patients with acute-on-chronic liver failure (ACLF). There is a lack of data assessing the healthcare utilization and outcomes of patients with APASL-defined ACLF undergoing living donor liver transplantation (LDLT). Our aim was to assess pre-LT healthcare utilization and post-LT outcomes in such patients. Methods Patients with ACLF who underwent LDLT at our center between 1st April 2019 and 1st October 2021 were included. Results Seventy-three ACLF patients willing to undergo LDLT were listed; eighteen patients died within 30 days. Fifty-five patients underwent LDLT (age:38.05 ± 14.76 years; alcohol:52.7%; males:81.8%). Most were in grade II ACLF (87.3%) at the time of LDLT (APASL ACLF Research Consortium [AARC] score: 9.05 ± 1; MELD NA: 28.15 ± 4.13). Survival rate was 72.73%; mean follow-up period of 925.21 days; 58.2% (32/55) developed complications during the first year post-LT; 45% (25/55) and 12.7% (7/55) developed infections within and after 3 months. Pre-LT, each patient required a median of 2 (1–4) admissions for 17 (4–45) days. Fifty-six percent (31/55) of patients underwent plasma exchange pre-LDLT. A median amount of Rs. 8,25,090 (INR 26,000–43,58,154) was spent to stabilize the patient (who were sicker and waited longer to undergo LDLT); though post-LT survival benefit was not observed. Conclusions LDLT was associated with 73% survival and, thus, is a viable option in those with APASL-defined ACLF. There was a pre-LT high healthcare resource utilization of plasma exchange, with the intention of optimization, while survival benefit has not been demonstrated. Supplementary Information The online version contains supplementary material available at 10.1007/s12072-023-10548-3.

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The Pattern of Alcohol Use in Alcohol-Related Cirrhosis in Indian Patients: AUDIT Indian Liver Study

Cited by 4 publications

References 46 publications

Biochemical and Molecular Study of Lactuca sativa on Diuresis- induced experimentally in Rats.

Biochemical and Molecular Study of Lactuca sativa on Diuresis- induced experimentally in Rats.

Understanding Substance Use Disorder and Comorbidities: Insights from South Asia

Healthcare utilization and outcomes of living donor liver transplantation for patients with APASL-defined acute-on-chronic liver failure

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