The Pattern of Fasting and Post 75 G Glucose Loading of Glucagon-Like Peptide 1 Levels in Obese and Non-Obese Subjects

Nugraha, Ida Bagus Aditya; Saraswati, Made Ratna; Suastika, Ketut

doi:10.3889/oamjms.2019.030

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…9 Nugraha et al research in 2018 showed that the patterns of GLP-1 levels post glucose loading were similar in obese and non-obese subjects, and there was a tendency of lower GLP-1 levels in fasting state and post-glucose loading in obese subjects compared to non-obese subjects. 10 In this study, in addition to assessing the response of giving 75 gram oral glucose loading to an increase in 30 th minute GLP1 levels in a population of diabetic subjects, it also investigated the relationship between glomerular filtration rate and GLP1 levels both fasting and post-loading of glucose. Basically, the secreted GLP1 hormone is immediately eliminated from circulation in less than five minutes, therefore the half-life of GLP1 in circulation is only about one to two minutes.…”

Section: Discussionmentioning

confidence: 99%

Correlation between glomerular filtration rate, fasting glucagon like peptide 1, and response after 75 gram oral glucose loading in type 2 diabetes mellitus

et al. 2020

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Background: Glucagon like peptide 1 (GLP1) is incretin hormone which possess biological effect on the kidneys. In conditions where the estimated glomerular filtration rate (eGFR) decreases or in the condition of chronic kidney disease (CKD), there is an increase in the inactive GLP1 or metabolites levels. Objective: To prove the relationship between eGFR with fasting and response of GLP1 after oral glucose loading in type 2 diabetes mellitus (T2DM) patients. Methods: An analytic cross sectional study on fasting and response of GLP1 after glucose loading in 60 subject with T2DM, age 35-65 years, was conducted. Each subject was obtained for fasting GLP1 and 30 minutes after 75 gram oral glucose loading. Subject were grouped based on eLFG into <60 ml/mnt/1.73m2 and ?60 ml/mnt/1.73 m2. Result: In the group of T2DM with eGFR <60 ml/mnt/1.73m2, median fasting GLP1 was 1.43 (0.38-8.50) ng/mL, in the group of eGFR ?60 ml/mnt/1.73 m2 was 1.57 (0.46-3.69) ng/mL (p=0.124). In the group of eGFR <60 ml/mnt/1.73 m2, median GLP1 after 30 minutes was increasing to 1.78 (1.12-8.35) ng/mL, as well as in group of eGFR ?60 ml/mnt/1.73 m2 1.79 (0.65-4.22) ng/mL (p=0.250). There were no correlation between fasting and 30 minutes after oral glucose load GLP1 with eGFR (p=0.510). Conclusion: There were no correlation between eGFR and GLP1, both fasting and 30 minutes after 75 gram oral glucose loading in T2DM. Level of GLP1 was increasing after oral glucose load in T2DM patients but not affected by stage of chronic kidney disease based on eGFR.

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Section: Discussionmentioning

confidence: 99%

Correlation between glomerular filtration rate, fasting glucagon like peptide 1, and response after 75 gram oral glucose loading in type 2 diabetes mellitus

et al. 2020

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Usefulness of circulating EPAC1 as biomarkers of therapeutic response to GLP-1 receptor agonists

et al. 2022

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Impacts of High-Fiber Snack on Satiety Hormonal Responses and Glucose Homeostasis in Healthy Volunteers

Sunarti

Santoso

Rubi

et al. 2023

CNF

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Background: Dietary fiber decreases the glycemic index and produces short-chain fatty acids (SCFAs) that will affect gastrointestinal hormone’s secretion, such as glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). This study investigated the effects of high-fiber snack on the glycemic index (GI), GLP-1, PYY and ghrelin secretions. Materials and methods: The study involved ten participants who received both 42 g of tested snack and glucose solution as a standard by washout period for a week. The standard glucose was prepared by dissolving 50 g of glucose powder in 200 mL of water (200 kcal), while 42 g of snack (195.8 kcal) containing 11.70% fiber from arrowroot, pumpkin, sweet potato, and cassava. The blood samples were collected at 0, 30, 60, 90, and 120 minutes after consuming snacks or standard glucose. Results: The GI of the tested snack is 69.14 that is categorized as medium. The area under glucose curve of the tested snack was lower compared to standard glucose (p= <0.001), and the plasma glucose was lower than standard glucose. Compared to standard glucose, the tested snacks had the area under the insulin curve lower than standard glucose, but it was not statistically significant (p= 0.082). No statistically significant was also found in the GLP-1, PYY and ghrelin concentrations between both standard glucose and tested snack intervention (p= 0.948). Conclusion: Our results suggest that consuming high-fiber snacks, with medium glycemic index, may have no effect on GLP-1, PYY, and ghrelin, otherwise it could improve glucose and insulin homeostasis

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The Pattern of Fasting and Post 75 G Glucose Loading of Glucagon-Like Peptide 1 Levels in Obese and Non-Obese Subjects

Cited by 3 publications

References 11 publications

Correlation between glomerular filtration rate, fasting glucagon like peptide 1, and response after 75 gram oral glucose loading in type 2 diabetes mellitus

Correlation between glomerular filtration rate, fasting glucagon like peptide 1, and response after 75 gram oral glucose loading in type 2 diabetes mellitus

Usefulness of circulating EPAC1 as biomarkers of therapeutic response to GLP-1 receptor agonists

Impacts of High-Fiber Snack on Satiety Hormonal Responses and Glucose Homeostasis in Healthy Volunteers

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