The pattern of neonatal admissions and mortality at a regional and district hospital in the Upper West Region of Ghana; a cross sectional study

Tette, Edem M. A.; Nartey, Edmund T.; Nuertey, Benjamín Demah; Azusong, Emmanuel A.; Akaateba, Dominic; Yirifere, Judith; Alandu, Augustine; Seneadza, Nana Ayegua Hagan; Gandau, Naa Barnabas; Renner, Lorna

doi:10.1371/journal.pone.0232406

Cited by 26 publications

(29 citation statements)

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“…Nigeria, and most of the patients were referred from other hospitals with complications on arrival. 31 The pattern and outcome of congenital malformations in their report was similar to that of our study with a preponderance of gastrointestinal malformations.…”

Section: Discussionsupporting

confidence: 87%

Determination of Neonatal Case-Specific Fatality Rates in a tertiary health institution in North Central Nigeria

Audu

Otuneye

Mairami

et al. 2020

Preprint

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Background The current neonatal mortality rate in Nigeria (37/1000) is among the highest in the world and the major causes have consistently been reported as sepsis, perinatal asphyxia and prematurity. However, case-specific fatality which defines the risk of dying from these and other neonatal morbidities is rarely emphasized. Determination of case-specific fatality rates (CSFR) may inform a change in our current approach to neonatal care interventions which may eventually bring about the much-needed reduction in our neonatal mortality rate. Our aim was to determine the case-specific fatality rates for the common causes of mortality among hospitalized neonates at the National Hospital Abuja (NHA).Methods: Relevant demographic and clinical data on all neonates admitted into the NICU at the NHA over a period of 13 months (January 2017 to February 2018) were extracted from the Neonatal Registry database and analyzed using appropriate statistical methods with the SPSS version 20 software. The case-specific fatality rates were computed for the predominant morbidities in addition to determination of the neonatal mortality rates and associated risk factors.Results and conclusion: A total of 730 neonates were admitted, out of which 391 (53.6%) were females, 396 (54.5%) were inborn and 396 (54.2%) were term. The three most prevalent morbidities were prematurity 272(37.2%), neonatal Jaundice 208(28.4%) and perinatal asphyxia 91(12.5%) while the most common causes of mortality were prematurity 47/113(41.6%), congenital malformations 27/113(23.9%) and perinatal asphyxia 26/113(23%). Congenital malformations had the highest case-specific fatality 27/83(32.5%) followed by Perinatal Asphyxia 26/91(28.6%) and prematurity 47/272(20.7%). The mortality pattern differed between inborn and out born babies. Implications of these case-specific fatality rates for targeted interventions are discussed.

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Section: Discussionsupporting

confidence: 87%

Determination of Neonatal Case-Specific Fatality Rates in a tertiary health institution in North Central Nigeria

Audu

Otuneye

Mairami

et al. 2020

Preprint

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“…Among neonatal factors, very low and low birth weights (54.4%) were found to be associated with overall clinically suspected sepsis in this study ( Table 2 ). Preterm birth and low birth weight were reported as associated risk factors of neonatal sepsis in previous studies as well [ 22 , 23 , 31 , 32 ]. However, others have found no association between neonatal sepsis and preterm birth or low birth weight [ 24 , 33 ].…”

Section: Discussionmentioning

confidence: 98%

“…This study describes the frequency of neonatal bacterial sepsis in two large tertiary care NICUs, which is one of the principal causes of hospitalization and mortality for neonates in developing countries [ 22 , 23 ]. We found the prevalence of bacteriologically confirmed neonatal sepsis (672/10,935, 6.1%) in the two study facilities to be lower than reports from Bangladesh (14.5%) [ 24 ] and Nepal (14%) [ 25 ], but similar to one from India (6.2%) [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Neonatal Sepsis, Antibiotic Susceptibility Pattern, and Treatment Outcomes among Neonates Treated in Two Tertiary Care Hospitals of Yangon, Myanmar from 2017 to 2019

Edwards

Pyakurel

et al. 2021

TropicalMed

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Neonatal sepsis is a leading cause of morbidity and mortality in developing countries. This study aimed to assess the proportion of culture-confirmed sepsis, bacteriological pathogen profile, culture report turnaround times, antibiotic susceptibility patterns, and treatment outcomes of all with neonatal sepsis admitted in two tertiary care hospitals in Yangon, Myanmar, 2017–2019. This was a cross sectional study utilizing a standardized electronic database and paper-based records. Bacteriological profiles and associated factors were analyzed with descriptive statistics and Poisson Regression. Of those with suspected sepsis, 42% were bacteriologically confirmed and 74% of confirmed sepsis was resistant to at least first-line antibiotics. Neonates with late onset sepsis (LOS) (aPR: 1.2 (95% CI: 1.1–1.4, p = 0.008)) were more likely to have bacteriologically confirmed sepsis (45%) versus early onset sepsis (38%). Gram-negative organisms were most commonly isolated (63%), associated with multidrug-resistant organisms and with a high case-fatality rate (64%). These findings suggest that enhanced national guidance regarding infection control and prevention, antibiotic stewardship, and first-line antibiotic choices need to be provided. The link between LOS with infection and prevention protocols needs to be further explored in this context to decrease sepsis risk, neonatal mortality, and reduce further antimicrobial resistance.

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“… 13 Jaundice was one of the most common causes of neonatal mortality and responsive for 6.7% of neonatal death in Ghana. 14 In Ethiopia, of the total death at Ayder, about 98.3% occurred during the first week of their life 15 and at Aroresa in Sidama, neonatal mortality was 41 per 1000 live birth and neonatal complication was one of the predictors for neonatal mortality. 16 In the northwest part of Ethiopia, the study revealed that Jaundice was one of the significant predictors for neonatal mortality, especially under 7 days of age.…”

Section: Introductionmentioning

confidence: 99%

Rate and Predictors of Neonatal Jaundice in Northwest Ethiopia: Prospective Cohort Study

Birhanu¹,

Atnaf²,

Molla³

et al. 2021

JMDH

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Background Neonatal jaundice is one of the most common clinical disorders occurred worldwide. About 1.1 million neonates develop jaundice per year globally and the vast majority of them found in sub-Saharan Africa and South Asia. There is a paucity of evidence on the incidence rate and predictors of neonatal jaundice in Ethiopia. Therefore, this study was aimed at determining the rate and predictors of neonatal jaundice in the northwest, Ethiopia. Methods A prospective cohort study design was conducted at Debre Markos comprehensive, specialized Hospitals using 334 neonates from October 1, 2019, to June 30, 2020. Using a systematic random sampling technique, the study subjects were drawn. Data were entered into the Epi-Data TM Version 4.2 and analyzed using STATA TM Version 14.0. The Kaplan-Meier survival curve was used to estimate the survival time. A generalized Log rank test was used to compare the survival curves of different categorical variables. Finally, both bi-variable and multivariable Cox-proportional hazards regression models were used to identify the predictors of neonatal jaundice. The Results The overall incidence rate of jaundice among neonates was 4.5 per 100 person-hours. Long duration of labor [ARR = 3.5; 95% confidence interval (CI), (2.8–8.7)], being male neonates [ARR= 5.2; 95% CI (3.5–7.3)], “O” blood group mothers [ARR = 4.5; 95% CI (3.4–10.3)], and having neonatal sepsis 3.4 [ARR=3.4; 95% CI: (2.5–6.1)] were predictors. Conclusion The incidence rate of jaundice was higher in this study than the finding of the previous one. Being male, prolonged duration of labor, “O” blood group mothers and sepsis were the significant predictors. Hence, an effort has to be made to decrease the incidence rate of neonatal jaundice through improving newborn care and timely intervention for neonates with sepsis and delivered at a long duration of time as well as the neonates born from “o” blood type mothers are our recommendation.

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The pattern of neonatal admissions and mortality at a regional and district hospital in the Upper West Region of Ghana; a cross sectional study

Cited by 26 publications

References 50 publications

Determination of Neonatal Case-Specific Fatality Rates in a tertiary health institution in North Central Nigeria

Determination of Neonatal Case-Specific Fatality Rates in a tertiary health institution in North Central Nigeria

Neonatal Sepsis, Antibiotic Susceptibility Pattern, and Treatment Outcomes among Neonates Treated in Two Tertiary Care Hospitals of Yangon, Myanmar from 2017 to 2019

Rate and Predictors of Neonatal Jaundice in Northwest Ethiopia: Prospective Cohort Study

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