The pattern of parotid gland secretion in cystic fibrosis of the pancreas

Marmar, Joel L.; Barbero, Giulio J.; Sibinga, Maarten S.

doi:10.1016/s0016-5085(66)80032-x

Cited by 27 publications

(9 citation statements)

References 7 publications

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“…Also, in agreement with our observations, in studies carried out by Marmar et al [14] and Blomfield et al [18] the chloride concentration in the saliva was high for CF patients in comparison with healthy subjects.…”

Section: Discussionsupporting

confidence: 94%

“…Blomfield et al [18,22] demonstrated that CF had no influence on the salivary flow of the patients. Marmar et al [14], on evaluating 12 patients with CF and 13 healthy children, found that the volume of saliva was higher in CF patients at all times after salivary stimulation. However, in our study, we found that the salivary flow is decreased in the CF group, consistent with the findings of other studies cited herein [23,24].…”

Section: Discussionmentioning

confidence: 99%

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Saliva as a potential tool for cystic fibrosis diagnosis

et al. 2013

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BackgroundSaliva and sweat are modified by cystic fibrosis (CF). In both cases the chloride and sodium ion concentrations for healthy subjects and CF patients differ, this representing a possible alternative tool for CF diagnosis. In this context, the aim of this study was to compare the concentrations of these ions in saliva samples taken from CF patients and healthy subjects.MethodsA case–control study was carried out at a university CF center, in which the saliva samples were analyzed on an ABL 835 Radiometer® to determine the ion concentration.ResultsFor the CF patients (n = 80) the values for the biochemical parameters of chloride, potassium and sodium ion concentration were higher (p < 0.009) and the volume and pH of the saliva were lower than in the case of healthy subjects (p < 0.009). For the healthy subjects group (n = 84) versus CF patients, according to the ROC curve, the values for sodium were: cutoff: 13.5 mmol/L, sensitivity: 73.4%, specificity: 70.6%; and for chloride: cutoff: 20 mmol/L, sensitivity: 68.1%, specificity: 72.9%.ConclusionsThe chloride and sodium concentrations in the saliva samples were higher for CF patients in comparison with healthy subjects. Thus, saliva as a tool for CF diagnosis can be considered a new challenge, and a population study including patients in all age classes needs to be performed, in different countries over the world, to extend the database to include a broad spectrum of information in order to identify normal ion concentration ranges for CF patients according to age, genotype and environment.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2614233148750145

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Saliva as a potential tool for cystic fibrosis diagnosis

et al. 2013

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“…In addition, we have demonstrated increased pupillary alpha-adrenergic and cholinergic sensitivity in CF patients and their parents (Davis, Shelhamer and Kaliner 1980;Davis 1984). These findings are consonant with other work showing increased sensitivity of CF sweat and salivary glands to cholinergic stimuli (Sibinga and Barbero 196V, Marmar, Barbero and Sibinga 1966).…”

supporting

confidence: 92%

Physiologic Implications of the Autonomic Aberrations in Cystic Fibrosis

Davis¹

1986

Horm Metab Res

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Cystic fibrosis patients and their parents have increased alpha-adrenergic sensitivity, increased cholinergic sensitivity, and reduced beta-adrenergic sensitivity. This combination of autonomic aberrations has been associated with increased airway reactivity in other disease populations. Although studies of airway reactivity are difficult to interpret in the cystic fibrosis patients themselves, the parents have no apparent pulmonary infection or inflammation, and one-third of these people have increased airway reactivity. Moreover, parents of children with cystic fibrosis have increased prevalence of wheezing and lung disease in childhood. Airway reactivity has been associated in other populations, with increased risk of obstructive pulmonary disease. Further studies are required to test the hypothesis that heterozygosity for CF is a risk factor for development and progression of obstructive pulmonary disease.

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“…They found evidences of calcium deposition and signs of reparative fibrosis in the bowel of CF patients. Then, Marmar et al showed altered calcium in parotid gland secretions [185] and Blomfield et al, reported hypersecretion of zymogen granules in the submandibular saliva, with elevated calcium concentrations [186]. Since these initial reports, many investigators found alterations in calcium secretion and homeostasis in CF.…”

Section: Altered Ca2+ Homeostasis In Mitochondriamentioning

confidence: 99%

CFTR activity and mitochondrial function

Valdivieso

Santa‐Coloma

2013

Redox Biology

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Cystic Fibrosis (CF) is a frequent and lethal autosomal recessive disease, caused by mutations in the gene encoding the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). Before the discovery of the CFTR gene, several hypotheses attempted to explain the etiology of this disease, including the possible role of a chloride channel, diverse alterations in mitochondrial functions, the overexpression of the lysosomal enzyme α-glucosidase and a deficiency in the cytosolic enzyme glucose 6-phosphate dehydrogenase. Because of the diverse mitochondrial changes found, some authors proposed that the affected gene should codify for a mitochondrial protein. Later, the CFTR cloning and the demonstration of its chloride channel activity turned the mitochondrial, lysosomal and cytosolic hypotheses obsolete. However, in recent years, using new approaches, several investigators reported similar or new alterations of mitochondrial functions in Cystic Fibrosis, thus rediscovering a possible role of mitochondria in this disease. Here, we review these CFTR-driven mitochondrial defects, including differential gene expression, alterations in oxidative phosphorylation, calcium homeostasis, oxidative stress, apoptosis and innate immune response, which might explain some characteristics of the complex CF phenotype and reveals potential new targets for therapy.

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The pattern of parotid gland secretion in cystic fibrosis of the pancreas

Cited by 27 publications

References 7 publications

Saliva as a potential tool for cystic fibrosis diagnosis

Saliva as a potential tool for cystic fibrosis diagnosis

Physiologic Implications of the Autonomic Aberrations in Cystic Fibrosis

CFTR activity and mitochondrial function

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