The Pattern of Recovery of Erythropoiesis in Heavily Irradiated Mice Receiving Transplants of Fetal Liver

Kubanek, B; Rencricca, Nicholas J.; Porcellini, A; Howard, Donald; Stohlman, Frederick

doi:10.3181/00379727-131-33988

Cited by 18 publications

(4 citation statements)

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“…It has been shown that the generation time of cells of the neural tube of 1-day-old chick embryos was 5 h, compared with 16 h in the 6-day-old embryo (Fujita 1962). The erythropoiesis in heavily irradiated mice receiving transplants of fetal haematopoietic stem cells recovered much faster than in mice receiving stem cells from adult donors (Kubanek et al 1969, Haskill & Moore 1970. However, the above-mentioned studies were performed using continuously dividing cells and the results are therefore not directly comparable with non-dividing resting cells.…”

Section: Discussionmentioning

confidence: 99%

The Activation of Fetal Lymphocytes

Weber¹,

Santesson²,

Skoog³

1973

Scandinavian Journal of Haematology

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Fetal lymphocytes from the cord blood of normal full‐term fetuses can be stimulated in vitro by PHA to transformation and mitotic division. The reaction kinetics differ from those of adult cells, in that the minimum G1 period is about 4 h shorter. However, the cord blood also contains a small number of lymphocytes, which enter the S period very soon after the addition of PHA, i.e. they have been prestimulated in vivo. These cells are completely lacking in adult blood. In addition, fetal lymphocytes show a significantly higher spontaneous transformation ratio. Possible reasons for these differences are discussed.

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Section: Discussionmentioning

confidence: 99%

The Activation of Fetal Lymphocytes

Weber¹,

Santesson²,

Skoog³

1973

Scandinavian Journal of Haematology

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“…Iron uptake did not increase in the recipient spleen at any time. It is interesting to note that uptake of iron by embryonic haemopoietic cells is increased when compared to recipients of adult bone marrow or fetal liver (Kubanek et al, 1969). The increased erythropoietic activity, linked with the apparent rapid cell cycle, may result in this increased uptake.…”

Section: Haematological and Immunological Assays On Embryonic Haemopomentioning

confidence: 96%

“…Earlier workers have shown that embryonic haemopoietic stem cells arise in the yolk sac of the developing mouse embryo on day 7 of gestation (Moore and Metcalf, 1970). During differentiation of the fetus, the haemopoietic cells migrate to the fetal liver, and many workers have used fetal liver to rescue lethally X-irradiated mice (Barnes et al, 1958;Kubanek et al, 1969).…”

Section: In-vivo Donor Cells Grafted Into X-irradiated or Geneticallymentioning

confidence: 98%

Embryonic stem cell grafting: the therapy of the future?

Hollands¹

1991

Human Reproduction

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The grafting of mouse embryonic haemopoietic cells into deficient recipients is discussed. Donor cells can be obtained from post-implantation mouse embryos in vivo and used to treat X-irradiated or genetically anaemic recipients. The concept of grafting embryonic haemopoietic cells into normal, untreated recipients is also described. Preimplantation mouse blastocysts grown in vitro for 3-4 days can also be used as a source of donor cells. The haematological and immunological aspects of embryonic cell grafting are discussed, followed by a description of current xenotransplantation experiments, including rat into mouse and human into mouse. The review concludes with a discussion of the application of embryonic cell grafting to other tissues and a look into the possible future of this technique.

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“…The studies on FL as being a potent hematopoietic organ, began in the 1960s with the demonstration of its reconstitution ability (Kubanek et al, 1969). In the past decades, many fancy and highly sensitive techniques have been applied to dissect and map the FL niche, the spatial location of HSCs, as well as key signaling pathways that regulate HSC expansion.…”

Section: Remaining Questionsmentioning

confidence: 99%

Fetal liver: an ideal niche for hematopoietic stem cell expansion

Gao

Liu

2018

Sci. China Life Sci.

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Fetal liver (FL) is an intricate and highly vascularized hematopoietic organ, which can support the extensive expansion of hematopoietic stem cells (HSCs) without loss of stemness, as well as of the downstream lineages of HSCs. This powerful function of FL largely benefits from the niche (or microenvironment), which provides a residence for HSC expansion. Numerous studies have demonstrated that the FL niche consists of heterogeneous cell populations that associate with HSCs spatially and regulate HSCs functionally. At the molecular level, a complex of cell extrinsic and intrinsic signaling network within the FL niche cells maintains HSC expansion. Here, we summarize recent studies on the analysis of the FL HSCs and their niche, and specifically on the molecular regulatory network for HSC expansion. Based on these studies, we hypothesize a strategy to obtain a large number of functional HSCs via 3D reconstruction of FL organoid ex vivo for clinical treatment in the future.

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The Pattern of Recovery of Erythropoiesis in Heavily Irradiated Mice Receiving Transplants of Fetal Liver

Cited by 18 publications

References 0 publications

The Activation of Fetal Lymphocytes

The Activation of Fetal Lymphocytes

Embryonic stem cell grafting: the therapy of the future?

Fetal liver: an ideal niche for hematopoietic stem cell expansion

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