The pattern recognition molecule collectin-L1 in critically ill children

Ingels, Catherine; Vanhorebeek, Ilse; Derese, Inge; Jensen, Lisbeth; Wouters, Pieter; Thiel, Steffen; Berghe, Greet Van den

doi:10.1038/pr.2016.76

Cited by 6 publications

(4 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…78 Moreover, lower serum levels were found in chronically ill children compared with healthy controls, while high levels upon admission correlated with increased risk of secondary infections and extended stay in the intensive care unit. 79 These findings are certainly difficult to interpret and do highlight the need of further characterization of the biological function of CL-10.…”

Section: Functionmentioning

confidence: 99%

A journey through the lectin pathway of complement—MBL and beyond

Garred

Genster

Pilely

et al. 2016

Immunological Reviews

335

302

View full text Add to dashboard Cite

Mannose-binding lectin (MBL), collectin-10, collectin-11, and the ficolins (ficolin-1, ficolin-2, and ficolin-3) are soluble pattern recognition molecules in the lectin complement pathway. These proteins act as mediators of host defense and participate in maintenance of tissue homeostasis. They bind to conserved pathogen-specific structures and altered self-antigens and form complexes with the pentraxins to modulate innate immune functions. All molecules exhibit distinct expression in different tissue compartments, but all are found to a varying degree in the circulation. A common feature of these molecules is their ability to interact with a set of serine proteases named MASPs (MASP-1, MASP-2, and MASP-3). MASP-1 and -2 trigger the activation of the lectin pathway and MASP-3 may be involved in the activation of the alternative pathway of complement. Furthermore, MASPs mediate processes related to coagulation, bradykinin release, and endothelial and platelet activation. Variant alleles affecting expression and structure of the proteins have been associated with a variety of infectious and non-infectious diseases, most commonly as disease modifiers. Notably, the severe 3MC (Malpuech, Michels, Mingarelli, and Carnevale) embryonic development syndrome originates from rare mutations affecting either collectin-11 or MASP-3, indicating a broader functionality of the complement system than previously anticipated. This review summarizes the characteristics of the molecules in the lectin pathway.

show abstract

Section: Functionmentioning

confidence: 99%

A journey through the lectin pathway of complement—MBL and beyond

Garred

Genster

Pilely

et al. 2016

Immunological Reviews

335

302

View full text Add to dashboard Cite

show abstract

“… 7 , 8 By contrast, in patients with systemic lupus erythematosus and in critically ill children, serum levels of CL-L1 were lower than in healthy controls. 9 , 10 Recently, mutation of COLEC10 has been found in 3MC syndrome patients, leading to craniofacial dysmorphism in children, 11 indicating that CL-L1 may have functions beyond stimulating complement cascade.…”

Section: Introductionmentioning

confidence: 99%

Decreased expression of <em>COLEC10</em> predicts poor overall survival in patients with hepatocellular carcinoma

Zhang¹,

Wu²

2018

CMAR

View full text Add to dashboard Cite

PurposeCollectin subfamily member 10 (COLEC10) encodes for collectin liver 1 (CL-L1), which is highly expressed in normal liver. Nevertheless, the association between COLEC10 and the prognosis of patients with hepatocellular carcinoma (HCC) remains unclear. To address this question, the prognostic value of COLEC10 expression in HCC was explored in this study.Patients and methodsData from The Cancer Genome Atlas were used to compared transcriptional levels of COLEC10 in HCC samples and samples from healthy controls. In addition, COLEC10 mRNA and protein expression levels were analyzed in HCC tissue samples from Chinese patients and matched adjacent nontumorous tissue samples, by quantitative reverse-transcription polymerase chain reaction and immunohistochemistry, respectively. The prognostic value of COLEC10 was further examined using the Gene Expression Profiling Interactive Analysis online tool.ResultsBoth the mRNA and protein levels of COLEC10 were found to be downregulated in HCC tissues compared with normal controls. Survival analysis indicated that decreased mRNA and protein levels of COLEC10 were related with shorter overall survival in patients with HCC. In addition, univariate and multivariate analysis demonstrated that COLEC10 is an independent prognostic factor for overall survival of HCC patients.ConclusionTogether, the results suggest that decreased expression of COLEC10 may predict poor overall survival in patients with HCC.

show abstract

“…Many collectins act in pathogen detection 30 , and COLEC10 is also suggested to have a role in immune system. For example, its low serum level associates with infections in children 39 and autoimmune disease systemic lupus erythematosus 31 . Additionally, COLEC10 may affect skin immune homeostasis, as it might have a role in neural crest cell migration and therefore possibly affect melanocyte production 30 .…”

Section: Discussionmentioning

confidence: 99%

Genetic study of psoriasis highlights its close link with socio-economic status and affective symptoms

Heikkilä

Sliz

Huilaja

et al. 2023

Preprint

View full text Add to dashboard Cite

Psoriasis is an inflammatory skin disease with an estimated heritability of around 70 %. Previous genome-wide association studies (GWASs) have detected several risk loci for psoriasis. To further improve the understanding of the genetic risk factors impacting the disease, we conducted a discovery GWAS in FinnGen and a subsequent replication and meta-analysis with data from the Estonian Biobank and the UK biobank; the study sample included 925 649 individuals (22 659 cases and 902 990 controls), the largest sample for psoriasis yet. In addition, we conducted downstream analyses to find out more about psoriasis cross-trait genetic correlations and causal relationships. We report 8 novel risk loci, most of which harbor genes related to nuclear factor kappa-light-chain-enhancer of activated B-cells-signaling pathway and overall immunity. Genetic correlations highlight the relationship between psoriasis and smoking, higher body weight, and lower education level. Additionally, we report novel causal relationships between psoriasis and mood symptoms, as well as two-directioned causal relationship between psoriasis and lower education level. Our results provide new knowledge on psoriasis risk factors, which may be useful in the development of future treatment strategies.

show abstract

The pattern recognition molecule collectin-L1 in critically ill children

Cited by 6 publications

References 33 publications

A journey through the lectin pathway of complement—MBL and beyond

A journey through the lectin pathway of complement—MBL and beyond

Decreased expression of <em>COLEC10</em> predicts poor overall survival in patients with hepatocellular carcinoma

Genetic study of psoriasis highlights its close link with socio-economic status and affective symptoms

Contact Info

Product

Resources

About