The patterns of children poisoning cases in community teaching hospital in Riyadh, Saudi Arabia

Alghadeer, Sultan; Alrohaimi, Manal; Althiban, Abeer; Kalagi, Nora A.; Balkhi, Bander; Khan, Anas

doi:10.1016/j.jsps.2017.10.007

Cited by 28 publications

(55 citation statements)

References 16 publications

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“…Several studies of acute pediatric poisoning have been conducted in Saudi Arabia [ 26 , 27 , 28 , 29 , 30 ]. A review by Izuora and Adeoye (2001) in Hafr Al Batin of seven years of case notes of children admitted to a single military hospital in the Eastern Province identified 168 accidental pediatric poisonings out of 9951 pediatric admissions (1.7%).…”

Section: Introductionmentioning

confidence: 99%

“…Children younger than two years of age (n = 459, 62%) were significantly affected by poisoning. Drug overdose (n = 119, 92.2%) was the major cause of poisoning and analgesics were the most commonly reported medicine (n = 26, 20.4%) [ 29 ]. They concluded with a recommendation, “to help to develop national plans to decrease the financial burden of emergency department congestion and hospital crowding” [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

“…The current literature about poisoning among children in Saudi Arabia is limited and lacking in Jeddah in terms of examination of poisoning agent and the medications used for management and clinical outcomes [ 26 , 27 , 28 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

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Frequency and Management of Acute Poisoning Among Children Attending an Emergency Department in Saudi Arabia

et al. 2020

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Background: Acute poisoning is one of the common medical emergencies in children that leads to morbidity and mortality. Medications and chemical agents play a major role in these adverse events resulting in social, economic, and health consequences. Aims of the study: This study aimed to evaluate the frequency and management of acute poisoning among children attending the emergency room at East Jeddah Hospital, Jeddah city, Saudi Arabia. Methods: This study was a retrospective chart review of all acute pediatric poisoning incidences in children (0–16 years of age) from October-21-2016 to March-03-2020 who were attending the emergency department. Data were analyzed via SPSS software. Results: A total of 69 incidences of acute poisoning in children who attended the emergency department at East Jeddah Hospital; males (n = 38, 55.1%). Most children were aged 5 years or younger (n = 41, 59.4%). Unintentional poisoning occurred among 56.5% of observed cases of which 52.2% occurred in children younger than 5 years; 7.20% (n = 5) of patients were 12 to 16 years of age and had deliberate self-poisoning. The association between type of poisoning and age groups was statistically significant (chi-square = 28.5057, p = 0.0001). Most incidences occurred at home (n = 64, 92.8%). Medicines were the most common cause of poisoning (n = 53, 76.8%). An excessive dose of prescribed medicine poisoning accidents was reported in 10.1% cases. Analgesics such as paracetamol were the most documented medication associated with poisoning (39.1%) followed by anticonvulsants and other central nervous system acting medicines (18.8%). The most common route of poisoning was oral ingestion (81.2%). One mortality case was documented. Conclusion: Although not common, accidental and deliberate acute poisoning in children does occur. More can be done to educate parents on safe storage of medicines, household cleaning and other products associated with acute poisoning in children. Likewise, children can be taught more about the risks of poisoning from an early age. As importantly, clinicians need to include more detailed notes in the electronic medical records (EMR) or the system needs to be improved to encourage completeness to more accurately inform the research evidence-base for future service design, health policy and strategy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Frequency and Management of Acute Poisoning Among Children Attending an Emergency Department in Saudi Arabia

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“…Considering unintentional intoxication, in research carried out in other countries, it is noticed that the ingestion of drugs is the main cause of accidental intoxication in children, as in Saudi Arabia where 70% of the exogenous intoxications were caused by drugs (Alghadeer et al, 2018) and in Taiwan 41.4% corresponded to drug intoxications (Lee et al, 2019). Drug intoxications that occurred in children have multifactorial causes and are generally related to specific conditions of each culture and region (Alghadeer et al, 2018). In relation to the age group of children up to 10 years, patterns similar to the results of our study of accidental intoxication were found in other Brazilian cities.…”

Section: Discussionmentioning

confidence: 99%

Profile of intoxications served at the 24-hour emergency service unit

Palma

Sales

Alves

et al. 2020

Rev. Ciênc. Farm. Básica Apl.

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“…Studies have indicated that Wnt/βcatenin signal pathway plays a role in the pathogenesis and progression of liver diseases [7] . The studies on the expression and clinical significance of Wnt5a, β-catenin, E-cadherin in hepatocellular carcinoma indicated that the expression of Wnt5a is negatively correlated with the clinical stage and prognosis of liver cancer, and can exert significant antioncogenic effect on tumor tissues [8][9][10][11][12][13][14] .…”

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confidence: 99%

The Role of Wnt/beta-Catenin Signal Pathway in the Pathogenesis of Nonalcoholic Fatty Liver Disease and the Effect of Atorvastatin Intervention

Sui¹,

Deng²,

Li³

et al. 2020

ijps

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Sui et al: The Role of Wnt/β-catenin Signal Pathway The purpose of this study was to analyze the pathogenesis of nonalcoholic fatty liver disease in rats and study the efficacy of atorvastatin intervention. One hundred Sprague Dawley rats were selected as test system. These rats were randomly divided into 5 groups, the control group, the nonalcoholic fatty liver disease group, high-dose atorvastatin group, medium-dose atorvastatin group and low-dose atorvastatin group, each containing 20 animals. An equal dose of sodium carboxymethylcellulose was applied to the model group and the control group; while atorvastatin perfusion was given to the other 3 groups. The levels of serum aspartate aminotransferase, alanine aminotransferase, triglycerides, total cholesterol, high-density lipoprotein, low-density lipoprotein and malondialdehyde were compared among the groups. The serum levels of aspartate aminotransferase, alanine aminotransferase, triacylglycerol and total cholesterol of the high-fat diet model group were significantly higher; moreover, the expression levels of MMP2, MMP9, Wnt1, Wnt4, host-catenin were significantly elevated. Treatment with atorvastatin could effectively ameliorate this abnormal condition but at high doses. Atorvastatin appears to inhibit the Wnt/ β-catenin signal pathway and achieve good curative effect against nonalcoholic fatty liver disease.

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The patterns of children poisoning cases in community teaching hospital in Riyadh, Saudi Arabia

Cited by 28 publications

References 16 publications

Frequency and Management of Acute Poisoning Among Children Attending an Emergency Department in Saudi Arabia

Frequency and Management of Acute Poisoning Among Children Attending an Emergency Department in Saudi Arabia

Profile of intoxications served at the 24-hour emergency service unit

The Role of Wnt/beta-Catenin Signal Pathway in the Pathogenesis of Nonalcoholic Fatty Liver Disease and the Effect of Atorvastatin Intervention

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