2024
DOI: 10.21203/rs.3.rs-3993048/v1
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The PDE4DIP-AKAP9 axis promotes lung cancer growth through modulation of PKA signalling

Xincheng Lu,
Yangyang Fu,
Shishun Huang
et al.

Abstract: Phosphodiesterase 4D interacting protein (PDE4DIP) is a Golgi/centrosome-associated protein that plays critical roles in the regulation of microtubule dynamics and maintenance of the Golgi structure. However, its biological role in human cancer remains largely unknown. In this study, we showed that PDE4DIP is overexpressed in human non-small cell lung cancer (NSCLC) tissues and that upregulated PDE4DIP expression is associated with poor prognosis in patients with lung cancer. We demonstrated that PDE4DIP knock… Show more

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