The Peanut Allergy Burden Study: Impact on the quality of life of patients and caregivers

Nowak‐Węgrzyn, Anna; Hass, Steven; Donelson, Sarah M.; Robison, Dan; Cameron, Ann; Etschmaier, Martine; Duhig, Amy; McCann, William

doi:10.1016/j.waojou.2021.100512

Cited by 47 publications

(43 citation statements)

References 27 publications

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“…The APPEAL study was a large quantitative and qualitative study assessing the psychosocial burden of PA in eight European countries, with the focus of the current article on the experience of participants in the UK and Ireland. The results detailed in this paper extend our understanding of the substantial burden of PA in the daily life of individuals with PA and their caregivers, compared with other quality-of-life surveys of PA patients and caregivers in other countries, including the US, Canada, and Switzerland, by highlighting that it is situation specific and because this study also examined coping strategies [ 25 – 28 ]. The survey phase of the study showed the high proportion of people with PA and their caregivers reporting negative emotions such as frustration, stress, worry and uncertainty due to PA.…”

Section: Discussionsupporting

confidence: 57%

Allergy to Peanuts imPacting Emotions And Life (APPEAL): The impact of peanut allergy on children, teenagers, adults and caregivers in the UK and Ireland

Tsoumani

Regent²,

Warner³

et al. 2022

PLoS ONE

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The Allergy to Peanuts imPacting Emotions And Life study (APPEAL) explored the psychosocial burden of living with self-reported peanut allergy experienced by children, teenagers, adults and caregivers in the UK and Ireland. A two-stage (quantitative survey and qualitative interview [APPEAL-1]), cross-sectional study of the psychosocial burden of peanut allergy (APPEAL-2) was conducted. Quantitative data were evaluated using descriptive statistics and qualitative data were analysed using MAXQDA software. A conceptual model specific to UK and Ireland was developed using the concepts identified during the analysis. A total of 284 adults in the UK and Ireland completed the APPEAL-1 survey and 42 individuals participated in APPEAL-2. Respondents reported that peanut allergy restricts their choices in various situations, especially with regard to choosing food when eating out (87% moderately or severely restricted), choosing where to eat (82%), special occasions (76%) and when buying food from a shop (71%). Fifty-two percent of survey participants and 40% of interview participants reported being bullied because of PA. Psychological impact of peanut allergy included feeling at least moderate levels of frustration (70%), uncertainty (79%), and stress (71%). The qualitative analysis identified three different types of coping strategies (daily monitoring or vigilance, communication and planning) and four main areas of individuals’ lives that are impacted by peanut allergy (social activities, relationships, emotions and work [adults and caregivers only]). The extent of the impact reported varied substantially between participants, with some reporting many negative consequences of living with peanut allergy and others feeling it has minimal impact on their health-related quality of life. This large survey and interview study highlight the psychosocial burden of peanut allergy for adults, teenagers, children and caregivers in the UK and Ireland. The analysis demonstrates the wide variation in level of impact of peanut allergy and the unmet need for those individuals who experience a substantial burden from living with peanut allergy.

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Section: Discussionsupporting

confidence: 57%

Allergy to Peanuts imPacting Emotions And Life (APPEAL): The impact of peanut allergy on children, teenagers, adults and caregivers in the UK and Ireland

Tsoumani

Regent²,

Warner³

et al. 2022

PLoS ONE

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“…Review of the included studies suggests that pediatric food allergy has a negative impact on the HRQL of children and teens. In eleven of the fourteen studies (78%) that employed the use of a comparison group, children and teens with food allergy were found to have significantly lower levels of HRQL in at least one domain 16‐29 . Statistically significant differences emerged most frequently in the domains related to total HRQL (66%), followed by social functioning (58%), emotional functioning (54%), and physical functioning (54%).…”

Section: Resultsmentioning

confidence: 99%

The burden of food allergy on children and teens: A systematic review

Golding

Batac

Gunnarsson

et al. 2022

Pediatric Allergy Immunology

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Background Over the last two decades, researchers have placed increasing attention on understanding how food allergy affects the health‐related quality of life (HRQL) and psychosocial well‐being of children and teens. In response, a number of reviews have been published that aim at synthesizing the literature. However, many of these papers focus narrowly on HRQL or suffer from methodological limitations. Method The current review aims to fill this gap by providing a comprehensive overview of the burden of pediatric food allergy by synthesizing the quantitative and qualitative literature. Results Findings from the present review provide evidence of reduced HRQL among children and teens with food allergy, particularly older children and those with more severe manifestations of the condition. In comparison to HRQL, the link between food allergy and psychosocial functioning is less clear; however, some evidence can be cited linking food allergy to greater levels of psychological distress. Qualitative evidence suggests that the burden of pediatric food allergy largely stems from worries surrounding exposures outside of the home and the social consequences of the condition. The current review also highlights several gaps in the literature, including a paucity of longitudinal research, research focused on predictors of psychological distress among children and teens with food allergy as well as a dearth of studies comparing rates of bullying in food‐allergic and non‐food‐allergic samples. Conclusion More emphasis should be placed on not only alleviating the social and psychological consequences of food allergy, but also on identifying and assisting those most acutely burdened by the condition.

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“…3 Dichas reacciones no solo tienen una gran repercusión a nivel clínico, además pueden acarrear una importante carga económica y social perjudicando la calidad de vida de los pacientes. [4][5][6][7][8] Además del mayor coste de los alimentos libres de componentes compuestos perjudiciales (antígenos) como el gluten, lactosa, etc, la ubiquidad de estos antígenos tiene un fuerte impacto tanto en la industria como en servicios de restauración y de manufacturación de alimentos; lo cual implica que los pacientes eviten reuniones sociales y sufran una mayor carga psicológica. Así mismo, algunas reacciones alimentarias pueden resultar fatales en algunos casos.…”

Section: Introductionunclassified

Reacciones adversas a los alimentos: ¿Cuál es el papel de los microorganismos?

Caminero¹

2021

Acta gastroenterol. latinoam.

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It is estimated that around 25% of the population worldwide experience adverse reactions to food, which are very diverse based on both etiology and clinical presentation. According to the pathophysiological processes involved, adverse reactions to foods can be broadly classified as sensitivities or intolerances, depending on whether they are immune-mediated, or not. Specifically, food sensitivities have become a growing clinical, economic, and social problem nowadays. Although the reason for the increased prevalence of well-determined food sensitives such as celiac disease and food allergies is not well understood, the role of microbes in both inducing and protecting from these conditions has been proposed. First, several studies suggest that the gut microbiota, the vast number of microbes that live in our digestive tract, influence the appearance of different adverse reactions to food. These studies are based on observational changes in the composition and function of the fecal microbiota of celiac, allergic and food intolerant patients when compared to controls or healthy participants. Second, infectious microbial agents have been related to the loss of oral tolerance towards dietary components and the occurrence of different adverse reactions to foods. However, how could microbes participate in food sensitivities and intolerances from a mechanistic point of view? Preclinical studies with animal models not only support observations in humans, they also show a causal role of microbes in the occurrence and course of these diseases, while informing the specific underlying mechanisms. The aim of this review is to summarize the scientific evidence that supports the role of microbes in the main adverse reactions to food described, with an emphasis on the underlying mechanisms. The discovery of the main molecular pathways involved in pathogenic reactions to diet foods will accelerate the development of new therapeutic approaches with the aim of preventing and treating food sensitivities and intolerances.

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The Peanut Allergy Burden Study: Impact on the quality of life of patients and caregivers

Cited by 47 publications

References 27 publications

Allergy to Peanuts imPacting Emotions And Life (APPEAL): The impact of peanut allergy on children, teenagers, adults and caregivers in the UK and Ireland

Allergy to Peanuts imPacting Emotions And Life (APPEAL): The impact of peanut allergy on children, teenagers, adults and caregivers in the UK and Ireland

The burden of food allergy on children and teens: A systematic review

Reacciones adversas a los alimentos: ¿Cuál es el papel de los microorganismos?

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