1990
DOI: 10.1007/bf00231258
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The pearl mutation accelerates the schedule of natural cell death in the early postnatal retina

Abstract: The time of maximal occurrence of pyknotic nuclei in the retinal ganglion cell layer of postnatal pearl mutant mice is earlier than that in normal mice (Linden and Pinto 1985). Both ganglion and displaced amacrine cells and glia populate the ganglion cell layer. Thus, in order to show that ganglion cells themselves are affected, we counted the numbers of surviving axons in the optic nerve of postnatal day (PND) 0, 4, 12 and adult mice. On PND 0, pearl mutant mice had 139,000 +/- 2800 (SEM) optic axons, about 8… Show more

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Cited by 26 publications
(19 citation statements)
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“…1m). Postnatal rats had the highest number of RGCs, with 75,000±18,000 cells at P0 falling to around 32,000±8,440 RGCs by P8 which is consistent with previous studies of postnatal cell death showing that approximately 50% of RGC die during early development (Bonfanti et al 1996;Horsburgh and Sefton 1987;Perry et al 1983;Williams et al 1990). The number of purified RGCs reached a plateau after P8 and there was little change in RGC numbers in cultures if P21 (28,600± 2,698) or P90 (27,200±787) rats.…”
Section: Adult Rgc Purificationsupporting
confidence: 90%
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“…1m). Postnatal rats had the highest number of RGCs, with 75,000±18,000 cells at P0 falling to around 32,000±8,440 RGCs by P8 which is consistent with previous studies of postnatal cell death showing that approximately 50% of RGC die during early development (Bonfanti et al 1996;Horsburgh and Sefton 1987;Perry et al 1983;Williams et al 1990). The number of purified RGCs reached a plateau after P8 and there was little change in RGC numbers in cultures if P21 (28,600± 2,698) or P90 (27,200±787) rats.…”
Section: Adult Rgc Purificationsupporting
confidence: 90%
“…The number of RGCs in postnatal rat is higher than that in adult rat and decreases during early postnatal life (Bonfanti et al 1996;Katz and Robison 1986;Perry et al 1983;Weisse 1995;Williams et al 1990). Many of the RGCs die during the early postnatal period through the process of naturally occurring cell death which ends at P8-P10 (Barres et al 1988;Isenmann et al 2003;Potts et al 1982;Rohrer et al 2001;Williams et al 1990).…”
Section: Discussionmentioning
confidence: 97%
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“…We find that the total number of cells in the RGC layer at P1 (115,000; Table 1) is approximately equal to the number of fibers in the optic nerve at P0 (128,000) (Williams et al, 1990). We conclude, therefore, that similar to those of the rat, virtually all cells found in this layer of newborn mouse retina are indeed ganglion cells.…”
Section: Rescue Of Rgcs From Naturally Occurring Cell Deathmentioning
confidence: 56%
“…In rats, ϳ50% of RGCs die during the first 10 -14 postnatal days Horsburgh and Sefton, 1987). Similarly, in the retina of the mouse, up to 60% of ganglion cells die between P0 and adulthood (Williams et al, 1990). It has been demonstrated that at birth the ganglion cell layer of the rat retina is constituted almost entirely of ganglion cells Rabacchi et al, 1994a).…”
Section: Rescue Of Rgcs From Naturally Occurring Cell Deathmentioning
confidence: 99%