The Peculiarities of Immune Regulation and the Polymorphic Variants of Candidate Genes Associated With Them in Oil Production Workers With Vegetative Regulation Disorders

Abstract

The analysis of the peculiarities of the immune status and the associated polymorphic variants of candidate genes in workers of an oil-extracting industry with established disorders of autonomic regulation -vegetative dystonia syndrome -was carried out. Pathology of the autonomic nervous system in the examined group of persons exposed to a complex of harmful production factors (excessive concentrations of aromatic hydrocarbons, noise intensity, vibration, unfavorable climatic conditions) is associated with suppression of the cellular link of the immune response according to the criterion of reducing the number of activated CD3 + CD4 + lymphocytes relative to the group comparison (p < 0.05) with a simultaneous increase in the content of regulatory CD3 + C25 + CD127-lymphocytes in relation to the reference values (p < 0.05). Signs of inhibition of apoptosis processes (CD95 + deficiency) are observed in the examined individuals, regardless of the presence of autonomic regulation disorders. The humoral immune status of the surveyed contingent is characterized by an increased level of serum IgM production relative to the comparison group. A decrease in the phagocytic activity of leukocytes was established according to the criteria of the percentage of phagocytosis and absolute phagocytosis, as well as the level of expression of the neurotransmitterdopamine -relative to the comparison group. The revealed changes in immune and humoral regulation in oil production workers with vegetative dystonia syndrome are associated with the variant allele of the G>A CYP2C19*2 gene and the wild-type allele of the C>T FAS gene.