The response of evapotranspiration (ET) to drought is essential for understanding water availability under drought conditions, which has received increasing scientific attention but remains highly uncertain. An unprecedented extreme drought sweeping the whole Yangtze River Basin during the summer and autumn of 2022 provides a novel opportunity to explore the ET response to drought within large river basins. Here, we apply multiple ET products to investigate the spatiotemporal variation of ET during the 2022 extreme drought and analyse the response of ET to drought in the Yangtze River Basin. The results show that this drought, characterized by widespread substantial precipitation deficit and high level of atmospheric evaporative demand (AED), leads to evident abnormal ET. Over the whole basin, ET exhibits a notable increase in the initial 2 months of this drought, which can significantly reduce water availability. However, despite continued high AED, the increase in ET fails to remain in the following months due to limited moisture supply. This suggests that ET response to drought varies as drought progresses. Among other drought events from 2003 to 2022, the response of ET is similar to that in the 2022 extreme drought. Specifically, for most sub‐basins, ET typically shows positive anomalies in the early stage of drought, followed by negative anomalies in the late stage. Generally, our findings improve the understanding of the dynamic response of ET to drought at the basin scale, which is crucial for basin water security.