The Penn Parkinson's Daily Activities Questionnaire-15: Psychometric properties of a brief assessment of cognitive instrumental activities of daily living in Parkinson's disease

Brennan, Laura; Siderowf, Andrew; Rubright, Jonathan D.; Rick, Jacqueline; Dahodwala, Nabila; Duda, John E.; Hurtig, Howard I.; Stern, Matthew B.; Xie, Sharon X.; Rennert, Lior; Karlawish, Jason; Shea, Judy A.; Trojanowski, John Q.; Weintraub, Daniel

doi:10.1016/j.parkreldis.2016.02.020

Cited by 52 publications

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“…The PDAQ‐15 is a 15‐question scale, with each question scored 0 to 4 on a Likert scale with a total range of 0 to 60 points (higher score indicates better cognition‐related functional abilities). In‐depth overviews of the original PDAQ and the abbreviated PDAQ‐15 have been described previously …”

Section: Methodsmentioning

confidence: 99%

“…Indepth overviews of the original PDAQ and the abbreviated PDAQ-15 have been described previously. 2,21 The 15-item Geriatric Depression Scale (GDS-15) was used to assess patient mood. 22 Clinical examinations performed included the Motor Subscale (Part III) of the UPDRS and KI burden.…”

Section: Methodsmentioning

confidence: 99%

“…Parkinson's disease (PD) is a neurodegenerative disorder effecting motor, cognitive, and neuropsychiatric function and instrumental activities of daily living (IADL) . Whereas most IADL scales used in PD were designed to measure functional deficits in Alzheimer's disease, and are often correlated with motor scores, the Penn Parkinson's Daily Activity Questionnaire‐15 (PDAQ‐15) was created specifically to assess cognition‐related functional abilities in PD patients (PT) without a motor function confound …”

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confidence: 99%

“…1 Whereas most IADL scales used in PD were designed to measure functional deficits in Alzheimer's disease, and are often correlated with motor scores, the Penn Parkinson's Daily Activity Questionnaire-15 (PDAQ-15) was created specifically to assess cognition-related functional abilities in PD patients (PT) without a motor function confound. [2][3][4] PT with and without PD may be unable to give valid selfassessments of their cognitive deficits, tending to rate their disability as less severe than knowledgeable informants (KI). [5][6][7] It has been shown that even mildly cognitively impaired PD PT can misrepresent performance on IADLs, leading to disagreement with KI.…”

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confidence: 99%

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Cognitive Functional Abilities in Parkinson's Disease: Agreement Between Patients and Informants

Deck

Xie

Choi

et al. 2019

Movement Disord Clin Pract

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Background The Penn Parkinson's Daily Activities Questionnaire‐15 (PDAQ‐15) assesses cognition‐related instrumental activities of daily living (IADL) in Parkinson's disease (PD). Objectives To assess the degree and predictors of disagreement between patients (PT) and knowledgeable informants (KI) on the PDAQ‐15. Methods We recruited 254 PT and KI pairs (PT‐KI), determined predictors of agreement, and compared scores to a performance‐based functional measure (Direct Assessment of Functional Status [DAFS]; N = 61). Results PT and KI total score (intraclass correlation = 0.57) and individual item (Cohen's kappa = 0.46–0.62) agreement were moderate. Patient depression, global cognition, and caregiver burden (all P < 0.05), predicted PT‐KI discrepancy. PT‐KI discrepancy was highest in patients with a dementia diagnosis, followed by mild cognitive impairment and then normal cognition (all P < 0.01), with PT rating themselves relatively more functionally intact as cognition worsened. DAFS performance was more highly correlated with KI (r = 0.82; P < 0.001) than PT (r = 0.62; P < 0.001) PDAQ‐15 score. Conclusions Our results support using KI as proxies when assessing cognitive IADLs in PD PTs, particularly in cases of more advanced cognitive decline.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Cognitive Functional Abilities in Parkinson's Disease: Agreement Between Patients and Informants

Deck

Xie

Choi

et al. 2019

Movement Disord Clin Pract

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“…As such, FI captures detailed demographics; medical and psychiatric history; family neurological history; and participant responses to validated questionnaires on physical health, mental health, and health-related quality of life. [17][18][19][20][21][22]. Once enrolled, participants are asked to provide updated responses every 90 days for several years.…”

Section: Methodsmentioning

confidence: 99%

Innovative Recruitment Strategies to Increase Diversity of Participation in Parkinson’s Disease Research: The Fox Insight Cohort Experience

Dobkin

Amondikar

Kopil

et al. 2020

JPD

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Background: Clinical research in Parkinson's disease (PD) faces practical and ethical challenges due to two interrelated problems: participant under-recruitment and lack of diversity. Fox Insight (FI) is a web-based longitudinal study collecting patient-reported outcomes and genetic data worldwide to inform therapeutic studies. FI's online platform provides an opportunity to evaluate online strategies for recruiting large, diverse research cohorts. Objective: This project aimed to determine 1) whether FI's digital marketing was associated with increased enrollment overall and from under-represented patient groups, compared to traditional recruitment methods; 2) the clinical and demographic characteristics of samples recruited online, and 3) the cost of this online recruitment. Method: FI recruitment during a 6-week baseline period without digital promotion was compared to recruitment during several periods of digital outreach. Separate online recruiting intervals included general online study promotion and unique Facebook and Google ad campaigns targeting under-represented subgroups: early PD, late/advanced PD, and residents of underrepresented/rural geographic areas.

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Participant and Study Partner Reported Impact of Cognition on Functional Activities in Parkinson's Disease

Cholerton

Poston

Tian

et al. 2019

Movement Disord Clin Pract

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Introduction Introduction: Cognitive dysfunction is common in Parkinson's disease (PD) and associated with reduced functional abilities and increased dependence. To date, however, little is known about the relationship between performance of instrumental activities of daily living (IADLs) and cognitive stages in PD, and there are conflicting reports as to whether declines in specific cognitive domains predict IADL impairment. Methods Methods: Participants with PD were drawn from the Pacific Udall Center and included in the study if both participant and study partner IADL ratings and cognitive tests were completed (n = 192). Logistic regression analyses were performed to determine whether participant and/or study partner rating predicted mild cognitive impairment or dementia. Correlations are reported for the relationship between participant/study partner IADL reports as well as for specific cognitive tests. ResultsResults: Although both participant and study partner ratings of IADL performance were associated with a diagnosis of PD with dementia, only participant self-rating of functional ability was significantly associated with a diagnosis of PD with mild cognitive impairment. Functional ability correlated most strongly with measures of processing speed, auditory working memory, and immediate verbal recall for both the participant and study partner ratings. Conclusion Conclusion: For participants with PD in the early stages of cognitive decline, self-rating may be more sensitive to the impact of cognitive changes on IADL function than ratings made by a knowledgeable study partner. Changes in executive function, processing speed, and learning may indicate a higher likelihood of IADL impairment. Careful assessment of cognition and IADL performance is recommended to permit individualized interventions prior to significant disability.Cognitive impairment is pervasive in Parkinson's disease (PD), often resulting in devastating impacts on quality of life, functional performance, and independence. 1 A decline in the ability to perform instrumental activities of daily living (IADL) related to cognitive impairment, although often initially subtle, can negatively impact disease outcome if not identified and adequately compensated. 2 Although significant functional impairment may be more apparent in PD-related dementia (PDD), subtle deficits in complex IADLs occur frequently among those with PDrelated mild cognitive impairment (PD-MCI), and the presence of such deficits may help to reveal the presence of early cognitive decline. 3 The assessment of functional change in PD presents challenges, however. Performance-based measures are not often

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The Penn Parkinson's Daily Activities Questionnaire-15: Psychometric properties of a brief assessment of cognitive instrumental activities of daily living in Parkinson's disease

Abstract: Introduction-To describe the psychometric properties of the Penn Parkinson's Daily Activities Questionnaire-15 (PDAQ-15), a 15-item measure of cognitive instrumental activities of daily living for Parkinson's disease (PD) patients derived from the original 50-item PDAQ.

Cited by 52 publications

References 23 publications

Cognitive Functional Abilities in Parkinson's Disease: Agreement Between Patients and Informants

Cognitive Functional Abilities in Parkinson's Disease: Agreement Between Patients and Informants

Innovative Recruitment Strategies to Increase Diversity of Participation in Parkinson’s Disease Research: The Fox Insight Cohort Experience

Participant and Study Partner Reported Impact of Cognition on Functional Activities in Parkinson's Disease

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