The pentraxin family in autoimmune disease

Li, Yongzhen; Zhang, Shouzan; Liu, Jingqi; Zhang, Yudi; Zhang, Nan; Cheng, Quan; Zhang, Hao; Wu, Xiaochuan

doi:10.1016/j.cca.2023.117592

Cited by 3 publications

(1 citation statement)

References 193 publications

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“…Interestingly, PTX4 is not induced by IL-1 or LPS and does not act as an acute-phase protein. Its high expression has been found in traumatic brain injury (TBI) [54,55].…”

Section: Pentraxin Familymentioning

confidence: 99%

The Role of Pentraxin 3 in Gastrointestinal Cancers

Zajkowska,

Mroczko

2023

Cancers

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Gastrointestinal cancers have become a huge problem worldwide as the number of new cases continues to increase. Due to the growing need to explore new biomarkers and therapeutic targets for the detection and treatment of cancerous lesions, we sought to elucidate the role of Pentraxin-3 in the progression of cancerous lesions, as it is involved in the process of angiogenesis and inflammation. Statistically significant changes in the concentration of this parameter have emerged in many gastrointestinal cancer patients. Moreover, it is related to the advancement of cancer, as well as processes leading to the development of those changes. In the case of studies concerning tissue material, both increased and decreased tissue expression of the tested parameter were observed and were dependent on the type of cancer. In the case of cell lines, both human and animal, a significant increase in Pentraxin 3 gene expression was observed, which confirmed the changes observed at the protein level. In conclusion, it can be assumed that PTX3, both at the level of gene expression and protein concentrations, is highly useful in the detection of gastrointestinal cancers, and its use as a biomarker and/or therapeutic target may be useful in the future.

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“…Interestingly, PTX4 is not induced by IL-1 or LPS and does not act as an acute-phase protein. Its high expression has been found in traumatic brain injury (TBI) [54,55].…”

Section: Pentraxin Familymentioning

confidence: 99%

The Role of Pentraxin 3 in Gastrointestinal Cancers

Zajkowska,

Mroczko

2023

Cancers

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Evidence of Silencing of Intestinal Inflammatory and Immune Transcripts Following Induction of Joint Inflammation

Moran,

Li,

Shen

et al. 2024

Preprint

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Disrupted intestinal epithelial barrier function has been proposed to be integral to rheumatoid arthritis (RA) progression and pathogenesis. To further define the molecular pathways in synovial inflammation and a response of the intestinal tissues, we have now used a rat model of mono-joint inflammatory arthritis, induced by intra-articular injection (IAI) of Complete Freunds adjuvant (CFA). The predominant inflammatory response of a single injection of the adjuvant into the knee joint resulted in rapid and reproducible formation of a fibrotic myeloid-infiltrated synovial pannus. Our aim was to determine how intestinal tissues, including the proximal and distal ileum and distal colon, respond to inflammatory changes in the synovium in a temporally coordinated manner by comparing their transcriptomic landscapes using RNASeq analyses. We confirmed the timeline of joint inflammation by knee joint swelling measurement, synovial fluid levels of the acute phase protein Inter-α-trypsin inhibitor heavy chains (ITIH) and demonstrated a self-correcting response of trabecular and cortical bone to the CFA challenge. Intestine-specific responses were monitored by 16S microbiome amplicon sequencing, histopathology for mucus layer integrity, and immune cell immunohistochemistry. We present data showing that the intestinal tissue response to the acute joint inflammation was region specific, with the ileum primarily responding with increased mucus secretion and silencing of T cell specific pathways, whereas the colon showed a transient upregulation of macrophages, with a broader suppression of immune related and metabolic pathway related transcripts. However, at no time after CFA-IAI were there significant changes in the fecal microbiome composition of the ileum or the colon. In summary, our data report for the first time a suppression of intestinal inflammatory and immune responses following the induction of joint inflammation and only minimal and transient changes in the microbiome.

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The Impact of Pentraxin 3 on Crohn’s Disease Phenotype

Kofla-Dlubacz,

Pawlik-Sobecka,

Pytrus

et al. 2024

IJMS

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Pentraxin 3 [PTX3] is an acute-phase protein playing an important role in the regulation of the humoral arm of immune response. As one of the molecules from the conservative family of pentraxins, PTX3 is a soluble mediator involved in the transduction of pro-inflammatory signals between immunocompetent cells. Additionally, recognizing damage-associated molecular patterns (DAMPs) during tissue injury mediates wound healing; therefore, its concentration potentially correlates with the severity of fibrosis. The aim of our study was to evaluate the value of the PTX3 measurement as a phenotypic marker of the stenotic form of Crohn’s disease. The research covered 63 patients, 35 with the narrowing type (B2) and 28 with the inflammatory type (B2) of CD. The mean concentrations of PTX3 in the study were as follows: 3.06 ng/mL (95% CI:1.27–6.99) for the B1 phenotype, 4.89 ng/mL (95% CI:2.98–13.65) for the B2 phenotype, and 3.04 ng/mL (95% CI:1.01–4.97) for the control group. PTX3 concentrations reached the highest values in the B2 group and the lowest in the control group. The differences between the B1 and B2 groups were statistically significant at p < 0.001. The presented studies indicate the potential role of PTX3 in the monitoring of tissue remodeling and the development of fibrosis in CD.

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The pentraxin family in autoimmune disease

Cited by 3 publications

References 193 publications

The Role of Pentraxin 3 in Gastrointestinal Cancers

The Role of Pentraxin 3 in Gastrointestinal Cancers

Evidence of Silencing of Intestinal Inflammatory and Immune Transcripts Following Induction of Joint Inflammation

The Impact of Pentraxin 3 on Crohn’s Disease Phenotype

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