The performance of a fly-larva shell-derived chitosan sponge as an absorbable surgical hemostatic agent

Gu, Ruolan; Sun, Weizheng; Zhou, Hong Fang; Wu, Zhuona; Meng, Zhiyun; Zhu, Xiaoxia; Tang, Qing; Dong, Ji Ling; Dou, Guifang

doi:10.1016/j.biomaterials.2009.10.023

Cited by 121 publications

(60 citation statements)

References 31 publications

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“…Chitosan has attracted much attention as a biomedical material, as it exhibits a wide variety of biological activities, such as antitumor activities [7]- [9], immunostimulating effects [10], antiallergic effects [11], hemostatic agent [12], anticoagulant effects [13] [14] hypocholesterolemic effects [15], antiinflammatorty activities [16], free radical scavenging activities [17], antimicrobial effects [18], antibacterial effects [19] [20] wound-healing effects [21] [22], antifungal activities [23] [24] and antiviral activity [25]. However, because of its high molecular weight and water-insolubility, the applications of chitosan are severely limited.…”

Section: Introductionmentioning

confidence: 99%

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

El-Denshary¹,

Aljawish²,

El‐Nekeety³

et al. 2015

SNL

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This study was conducted to prepare chitosan nanoparticles (CNPs), to determine their properties and to evaluate the synergistic protective role of CNPs alone or in combination with quercetin (Q) against oxidative stress and hepatotoxicity in rats. Female Sprague-Dawley rats were divided into 12 groups (7 rats/group) and were maintained on their respective diet for 3 weeks as follow: control group, the group treated with CCl4 (100 mg/kg b.w twice a week); the groups received CNPs at low and high doses (140 and 280 mg/kg b.w); the group received Q (50 mg/kg b.w); the groups received CNPs at the low or high doses plus Q and the groups treated with CCl4 plus Q and/or CNPs at the two tested doses. Blood and liver samples were collected at the end of experiment period for biochemical and histological studies. The results indicated that chitosan showed deacetylation degree of 17.5% and 19.2% and the molar mass average of monomer was 168.35 g/mol and 169.1 g/mol by UV and IR methods respectively. The particle size of CNPs was around 100 nm with a rough surface. The in vivo results revealed that CCl4 induced biochemical and histological changes typical to those reported in the literature. Animals treated with CNPs at the two tested doses alone or in combination with Q were comparable to the control. CNPs alone or plus Q succeeded to induce significant improvements in the biochemical parameters and histological picture of the liver in rats treated with CCl4. This improvement was in dose-dependent manner for CNPs and was * Corresponding author. E. S. El-Denshary et al. 37more pronounced in the group treated with the high dose plus Q. It could be concluded that both CNPs and Q could induce protection against hepatotoxicity. Consequently, CNPs was a promise candidate as drug delivery in liver diseases treatments.

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Section: Introductionmentioning

confidence: 99%

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

El-Denshary¹,

Aljawish²,

El‐Nekeety³

et al. 2015

SNL

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“…Chitosan has that effect by increasing local akaryocyte aggregation, morphologic changes, thrombocyte activation and thrombocyte production. It is stated that chitosan has shown a perfect compatibility with blood and cells, when the bio -compatibility of chitosan is compared with gelatin sponge or oxidized cellulose [28]. With a study, in which the use of chitosan as a homoeostatic agent in the body during the pre -operative period was examined, it was reported that chitosan sponges had a good compatibility with the body like the materials that had been used for that purpose, did not cause any inflammation and also supported neoplasm and vascularity [28].…”

Section: Its Activity As Homoeostatic Agentmentioning

confidence: 99%

A Renewable Natural Bioactive Polysaccharide: An Overview to Chitosan

Ayhan¹,

Şanlıer²

2015

IJNFS

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Chitin is a polysaccharide, which can be found in the structures of some insects, yeasts and fungi in nature.Chitosan is a compound, which is obtained by de -acetylation of chitin. Apart from that, there is chitosan naturally on the cell walls of some fungi, in yeasts and protozoa and in the outer shells of crustaceans. Chitosan is a molecule, which is frequently used in health field and food industry. It is frequently used in bioactive packing especially for its antibacterial effect. In addition, it is used in many areas such as waste treatment for its antioxidant feature. Areas of use of chitosan are expanding because it is an edible agent and because of its low level of toxic activity, and new areas of use are discovered everyday in good and health sectors.

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“…For this reason, various topical hemostatic agents such as thrombin, porcine gelatin, bovine gelatin, bovine collagen, regenerated oxidized cellulose, and their combination products frequently have been used when hemorrhage is not controlled by conventional hemostatic methods. [6][7][8][9] Among them, thrombin is of increasing interest and can be applied to the bleeding site in a dry form or after reconstitution with sterile isotonic saline. 9 It is known that thrombin is a naturally derived enzyme that has had a prominent role in hemostasis for decades.…”

Section: Introductionmentioning

confidence: 99%

Nanocomplexation of thrombin with cationic amylose derivative for improved stability and hemostatic efficacy

Zhuang¹,

Li²,

Pang³

et al. 2015

IJN

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As a topical hemostatic agent, thrombin has wide application for many surgical treatments. However, native thrombin always suffers from its physical and chemical instabilities. In this work, a nanocomplexation strategy was developed for modifying the stability and hemostatic efficacy of thrombin, in which a water-soluble cationic amylose derivative containing poly( l -lysine) dendrons was prepared by a click reaction and then used to complex thrombin in an aqueous system. For resultant thrombin nanocomplexes, their morphology and particle size distribution were investigated. Their stabilities were studied in terms of activity retention percentages under different storage time, pH values, and illumination time. In addition, their ability to achieve in vitro fibrinogen and blood coagulation were evaluated. Via a rat hepatic hemorrhage model and a rat iliac artery hemorrhage model, these thrombin nanocomplexes were confirmed to have good tissue biocompatibility and in vivo hemostatic effectiveness.

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The performance of a fly-larva shell-derived chitosan sponge as an absorbable surgical hemostatic agent

Cited by 121 publications

References 31 publications

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

A Renewable Natural Bioactive Polysaccharide: An Overview to Chitosan

Nanocomplexation of thrombin with cationic amylose derivative for improved stability and hemostatic efficacy

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The performance of a fly-larva shell-derived chitosan sponge as an absorbable surgical hemostatic agent

Cited by 121 publications

References 31 publications

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

A Renewable Natural Bioactive Polysaccharide: An Overview to Chitosan

Nanocomplexation of thrombin with cationic amylose derivative for improved stability and&nbsp;hemostatic efficacy

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Nanocomplexation of thrombin with cationic amylose derivative for improved stability and hemostatic efficacy