The performance of noninvasive indexes of adults in identification of nonalcoholic fatty liver disease in children

Abstract

Background: The aim of this study is to evaluate the performance of three existing prediction scores which are applicable to adults for identifying nonalcoholic fatty liver disease (NAFLD) in Chinese children. Methods: We used data from routine check-up based medical records of 1845 children to validate the performance of three existing scoring systems including the hepatic steatosis index (HSI), Zhejiang University index (ZJU index), and triglyceride-glucose index (TyG index) in detection of NAFLD in children.Propensity score matching was applied to adjust for potential confounding effects in both training and validation cohorts. The area under the curve (AUC) of the receiver operating characteristic curve analysis was utilized to assess the performance of the three scoring systems.Results: Children with NAFLD had higher scores of HSI, ZJU index, and TyG index when compared with the control group (children without NAFLD). Elevated HSI, ZJU index, and TyG index scores were significantly associated with the presence of pediatric NAFLD since adjusted odds ratio and 95% CI with per interquartile range elevation of the HSI, ZJU index, and TyG index were

The Diagnostic and Prognostic Value of the Triglyceride-Glucose Index in Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD): A Systematic Review and Meta-Analysis

“…The comprehensive computer literature search from PubMed, MEDLINE, Web of Science, EMBASE and the Cochrane Library revealed 4722 articles, as shown in Figure 1 . Ultimately, 20 studies involving 165,725 participants were included [ 10 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ].…”

“…The detailed situation of the included studies is presented in Table 2 . The regions included China [ 10 , 21 , 22 , 23 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ] (n = 14), Iran [ 35 , 36 ] (n = 2), Korea [ 37 , 38 , 39 ] (n = 3) and Japan [ 24 ] (n = 1). Two studies [ 21 , 30 ] included only children, and 12 studies included only adults.…”

Comparison of the Diagnostic Value Between Triglyceride-glucose Index and Triglyceride to High-density Lipoprotein Cholesterol Ratio in Metabolic-associated Fatty Liver Disease Patients: A Retrospective Cross-sectional Study

“…Previous studies have shown that the incidence of MAFLD also signi cantly increases with the increase in TyG [33,34]. In other studies, the AUCs of the TyG index to detect adult MAFLD were 0.714-0.782, with MAFLD diagnosed by ultrasound [19,[35][36][37][38][39]. A study showed that the AUC of TyG was larger than that of ALT, with the AUC of TyG at 0.9 (95%CI 0.84-0.94) in biopsy-proven MAFLD with 80% sensitivity and 92% speci city when the cut-off value was 8.38 [40].…”

“…TyG is also associated with cardiometabolic diseases and is a risk prognostic factor for stroke, diabetes mellitus, acute myocardial infarction, and acute coronary syndrome [15][16][17]. In addition, TyG may be a useful indicator of MAFLD not only in adults but also in children and the elderly [18][19][20]. Therefore, this study aimed to compare the ability of TG/HDL-C and TyG to distinguish MAFLD from healthy people and establish a better prediction model for MAFLD.…”

Comparison of the Diagnostic Value Between Triglyceride-Glucose Index and Triglyceride-to-High Density Lipoprotein Cholesterol Ratio in MAFLD Patients: A Retrospective Cross-Sectional Study

“…With the increment of TyG, the incidence of MAFLD signi cantly increased (33,34). The AUCs of the TyG index demonstrated by some studies in detecting adult MAFLD were 0.714-0.782 and their MAFLD was diagnosed by ultrasound (19,(35)(36)(37)(38)(39). Two researches among them mentioned that the AUC of TyG was larger than ALT.Fedchuk L et al discovered that the AUC of TyG was up to 0.9 (95%CI 0.84-0.94) in biopsy-proven MAFLD with 80% sensitivity and 92% speci city when the cut-off value was 8.38 (40).…”