The performance study of developed cost-effective Compton Camera based on Ce:GAGG scintillator using experimental measurements and CCMod of GATE simulation module

Zarei, Hajar; Nagao, Yuto; Yamamoto, Kazuhito; Itoh, Masatoshi; Yamaguchi, Mitsutaka; Kawachi, Naoki; Watabe, Hiroshi

doi:10.1088/1748-0221/17/10/p10012

Cited by 2 publications

(5 citation statements)

References 19 publications

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“…The GATE simulation results obtained in this study are reliable according to good agreement between experiment and simulation results reported in our previous work [15]. The DE 𝑎 and spatial resolution for the energy range, 364-1000 keV, showed almost the same trends.…”

Section: Discussionsupporting

confidence: 89%

“…Our group designed two prototypes of SiPM-GAGG:Ce Scintillator Compton Cameras in different geometrical configurations. Both prototypes showed imaging resolution of 5 mm by MLEM algorithm for 511 keV gamma ray without any non-optimized setup [14,15]. Extensive research has been conducted on the application of the GAGG:Ce scintillator-based Compton camera as a nuclear medicine imaging device [8] in vivo imaging [6], multiple-gamma coincidence imaging [16], intraoperative imaging [17] and monitoring of particle therapy (proton therapy and heavy-ion therapy) [18,19] and internal radiotherapy [20,21].…”

Section: Jinst 18 P01035mentioning

confidence: 99%

“…In all studies, the intrinsic spatial blurring was defined as an ideal value by 1 mm FWHM close to pixel size. Our previous work described the scatterer and absorber's energy resolution as 18%, 16%, 14%, and 10% for energies 364, 511, 662, and 1000 keV, respectively [15]. No energy threshold for detectors was defined.…”

Section: Jinst 18 P01035mentioning

confidence: 99%

“…In addition, to eliminate back-scattering events, where the incident gamma rays are scattered at the absorber and photoelectrically absorbed at the scatterer, the deposited energy at the scatterer was limited as 𝐸1 < 𝐸/(1 + 2𝐸/𝑚𝑒𝑐 2 ), where 𝐸 is the initial energy of the incident gamma ray. Energy windows for the absorber are not defined in this study [15]. The selected coincidence events were used to obtain image reconstruction of the point source using a simple BP (back-projection) algorithm.…”

Section: Jinst 18 P01035mentioning

confidence: 99%

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Evaluation and optimization of geometry parameters of GAGG scintillator-based Compton Camera for medical imaging by Monte Carlo simulation

Zarei¹,

Razaghi²,

Nagao³

et al. 2023

J. Inst.

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In nuclear medicine, the development of portable imaging devices that provide high imaging resolution and sensitivity, capable of imaging gamma rays with a wide energy range and multiple radioisotopes tracing capabilities, is so important. These goals have been possible thanks to developing a compact Compton camera, a collimatorless detector coupled to compact silicon photomultiplier(SiPM) array, using scintillator crystal. In this study, the portable segmented GAGG:Ce scintillator-based Compton camera (CC) is optimized with the GATE, a Monte Carlo simulation toolkit based on Geant4, to maximize its performance for a wide range of gamma-ray energy (364–1000 keV). The geometrical parameters are selected as optimization parameters to investigate their effects on CC's performance, including imaging resolution and absolute detection efficiency (DE a ). The geometry parameters of CC include the planner area of scatterer and absorber detectors, their thicknesses, and the distance between them. The results for the energy range of 364–1000 keV show that the most important contributions to the spatial resolution and DE a of the camera are SAD (scatterer to absorber distance) and the scatterer area while changing absorber area (AA ) showed the most negligible impact. In the short SADs, imaging resolution and DE a are significantly affected by the detector's size and thickness. On the other hand, in the long SADs (> 4 cm), both spatial resolution and DE a are significantly affected by the detector's area but less affected by the detector's thickness. Decreasing the scatterer's thickness and the absorber's size or thickness improves imaging resolution without significantly reducing DE a . The simulation study's findings presented here will provide valuable guidelines for researchers choosing a desired CC's design according to particular objectives, manufacturing limitations in scintillator growth, cost, etc.

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Section: Discussionsupporting

confidence: 89%

Section: Jinst 18 P01035mentioning

confidence: 99%

Section: Jinst 18 P01035mentioning

confidence: 99%

Section: Jinst 18 P01035mentioning

confidence: 99%

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Evaluation and optimization of geometry parameters of GAGG scintillator-based Compton Camera for medical imaging by Monte Carlo simulation

Zarei¹,

Razaghi²,

Nagao³

et al. 2023

J. Inst.

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“…The transmission loss of the cable is only 2 dB at 100 MHz, which is acceptable for this system. The signals from the preamplifiers are fed to a weighted summing amplifier [16,17] to reduce the number of signals. The signals from the other eight detector heads are also fed to preamplifiers and then to the other weighted summing amplifier.…”

Section: Compact Positron Multiprobe System (Cpmps)mentioning

confidence: 99%

Development of a compact multiprobe system for monitoring positron-emitting tracers in plant stems

Nagao,

Suzui,

Yin

et al. 2024

J. Inst.

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Nondestructive monitoring of positron-emitting tracers in plant bodies at multiple points, including points separated by large distances, has been realised with the positron multiprobe system (PMPS) to investigate graminaceous plants, whose stems and leaves have simple shapes. Recently, the translocation of photosynthates into fruits has been studied intensively using a 11C tracer. The relatively complex shapes of the stems and leaves of these plants sometimes prevent the detector heads of the PMPS from approaching and being fixed to the target stem properly because of its relatively large and heavy detector heads based on photomultiplier tubes. Owing to the compactness, lightweightness and recent advances of silicon photomultipliers (SiPMs), fabricating compact and lightweight detector heads has become possible. In this study, we developed a compact PMPS (CPMPS) using SiPMs and successfully demonstrated its capability for monitoring a 11C tracer in strawberry stems. Moreover, we found that energy-window filtering markedly reduced noise events without radiation shielding. The dominant ionisation events detected by the CPMPS were Compton scattering and subsequent photoabsorption of a single 511 keV gamma ray, suggesting that the ionisation events of single-gamma-ray emitters, such as 42K, 43K, 54Mn, 59Fe and 65Zn, can be detected by the CPMPS. The developed CPMPS can also be applied to study the physiology of other plants with intricately shaped stems and leaves, such as the tomato and eggplant.

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The performance study of developed cost-effective Compton Camera based on Ce:GAGG scintillator using experimental measurements and CCMod of GATE simulation module

Cited by 2 publications

References 19 publications

Evaluation and optimization of geometry parameters of GAGG scintillator-based Compton Camera for medical imaging by Monte Carlo simulation

Evaluation and optimization of geometry parameters of GAGG scintillator-based Compton Camera for medical imaging by Monte Carlo simulation

Development of a compact multiprobe system for monitoring positron-emitting tracers in plant stems

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